c16 ceramide

C16 Ceramide (Palmitoyl Ceramide) is a naturally occurring small molecule that activates p53 by directly and selectively binding to it.

C16 Ceramide (d16:1,C16:0) is a bioactive sphingolipid that induces the formation and thermal stabilization of ordered phases and gel phases enriched in palmitoyl sphingomyelin domains within palmitoyl phosphatidylcholine (POPC) bilayers. It is found in human erythrocyte sphingomyelin.

C16 Ceramide-1-phosphate (d18:1 16:0) ammonium salt (C16 C1P ammonium salt) is an ester product used in synthesizing nanobiomaterials.

C16 Ceramide-d7 is a deuterated compound of C16 Ceramide.

C16 dihydro Ceramide (d18:0 16:0) (Cer(d18:0 16:0)) is a precursor for the synthesis of ceramides, induces autophagy in the perinuclear region, and can be used to study cell membrane stability and neurological diseases.

C16-Urea-Ceramide s a neutral ceramidase (nCDase) inhibitor. It is a bioactive ceramide.

C16 PEG-Ceramide, a polyethylene glycolylated ceramide, serves as a lipid carrier for delivery and induces autophagy. It is utilized in cancer research [1] [2].

C16((±)-2'-hydroxy) dihydro Ceramide (d18:0 16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16((±)-2'-hydroxy) dihydro Ceramide (d18:0 16:0) is 190249-36-6.

C16 (2'(S)-hydroxy) Ceramide (d18:1 16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16 (2'(S)-hydroxy) Ceramide (d18:1 16:0) is 890041-50-6.

C16 PEG750 Ceramide (C16 PEG Ceramide (MW 750)) is a PEG lipid used in the preparation of liposomes, applicable in drug delivery research.

13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in ordered lipid domains (lipid rafts). Sphingomyelinases remove phosphorylcholine from C16 sphingomyelin to produce C16 ceramide. While ceramides commonly induce apoptosis, ceramides with different fatty acid chain lengths might direct distinct functions and, in some cases, reduce apoptosis.

C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the 20S proteasome in HT-29 and HCT116, but not RIE-1, cells. It reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissue in an HT-29 mouse xenograft model when administered at doses of 1.25, 2.5, and 5 mg/kg for five days. |1. García-Barros, M., Coant, N., Kawamori, T., et al. Role of neutral ceramidase in colon cancer. FASEB J. 30(12), 4159-4171 (2016).

ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively).

C22 Ceramide (d18:1 22:0) (C22 Ceramide), a long-chain ceramide containing behenic acid, is an endogenous bioactive sphingolipid.C22-Ceramide specifically inhibits MCSR and reduces C16 ceramide channel formation in isolated rat liver mitochondria and liposomes.

C16 Galactosylceramide is a glycosphingolipid that contains a galactose moiety attached to a ceramide acylated with palmitic acid .

D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1 16:0)) is an endogenous ligand for the Macrophage-Inducible C-type Lectin (Mincle) with immunostimulatory properties [1].

C16 1-Deoxyceramide (m18:1 16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16 1-Deoxyceramide (m18:1 16:0) is 1246298-56-5.