bet

PROTAC BRD4 ligand-1, a component of Protac GNE-987, is a ligand for BRD4 and acts as an inhibitor of BET.

CPI-0610 carboxylic acid is an effective and selective small molecule inhibitor of bromine domain and outer end (BET) protein as a ligand of PROTAC target protein. CPI-0610 carboxylic acid may have anticancer and anticancer activities.

ARV-771 is an effective BET degrader based on PROTAC technology. The Kd for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1) and BRD4(2) are 34 and 4.7 respectively. , 8.3, 7.6, 9.6 and 7.6 nM.

PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins, with an IC50 of 9.6 nM.

PROTAC BET-binding moiety 1 is a crucial intermediate used in synthesizing high-affinity BET inhibitors.

PROTAC BET Degrader-10 (WO2017007612A1, example 37) is a highly efficient and selective small molecule compound designed to degrade BET protein BRD4. PROTAC BET Degrader-10 functions by utilizing specific ligands that connect Cereblon and BRD4, with a DC 50 value of 49 nM.

PROTAC BET Degrader-3 is a potent degrader of BET proteins based on the PROTAC (PROteolysis TArgeting Chimera) technology.

PROTAC BET Degrader-1 is a potent BET degrader utilizing the PROTAC mechanism.

BET-IN-6, a ligand with potent and high affinity for inhibiting BRD2 BRD4, plays a crucial role in the synthesis of PROTAC BRD2 BRD4 degrader-1 [1], targeting the protein BRD2 4.

PROTAC BET-binding moiety 2 is an inhibitor of the BET bromodomain.

BETd-260, a PROTAC linked by a Cereblon ligand and a BET ligand, has an inhibitory effect on BRD4 protein in leukemic cell lines.

dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.

I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).

dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.

BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.

dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50 5h of 500 nM ,and inactive on BRD4BD2

Azido-PEG4-tetra-Ac-beta-D-glucose is a polyethylene glycol (PEG)-based PROTAC linker used for PROTAC synthesis[1].

Propargyl-PEG4-beta-D-glucose is a polyethylene glycol (PEG) derivatized PROTAC linker used in the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].

Propargyl-PEG4-tetra-Ac-beta-D-glucose, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs [1].

PhoBET1 is a photocaged PROTAC that effectively induces BRD4 degradation, thus suppressing tumor growth [1].

Propargyl-PEG2-beta-D-glucose, a polyethylene glycol (PEG) derived linker compound, is specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Azido-PEG4-beta-D-glucose is a polyethylene glycol (PEG)-based linker compound crucial for the efficient synthesis of proteolysis targeting chimeras (PROTACs)[1].

dBET23 is a BRD4 degrader.

1-(Isopropylthio)-2,3,4,6-tetra-O-Ac-beta-D-glucosylpyranose is an alkyl chain-derived PROTAC linker used in the synthesis of PROTACs[1].