bacillus

Dalbavancin (BI-397), a novel second-generation lipoglycopeptide antibiotic, possesses in vitro activity against a variety of Gram-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE),Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively

Cephalosporinase, bacillus, are enzymes produced by Bacillus; these enzymes inactivate and degrade the effectiveness of cephalosporin antibiotics. Cephalosporins are a class of β-lactam antibiotics widely used to treat bacterial infections [1].

Neutral Proteinase, derived from Bacillus sp., serves as a biocatalyst and is a pivotal enzyme in novel biocatalyst technology. Enzyme engineering focuses on improving reaction kinetics, substrate selectivity, and maintaining activity under challenging conditions (e.g., low or high pH). By incorporating stimuli-responsive modifications, dynamic control of enzyme activity can also be achieved.

Keratanase II, from Bacillus circulans and expressed in E. coli, possesses transglycosylation activity. It effectively catalyzes α(2→3)-sialylated 6,6′-di-sulfo-LacNAc with two glycosyl acceptors, 6-sulfo-Lewis X and 6,6'-di-sulfo-LacNAc derivatives, generating sialic acid sulfohexose and sialic acid sulfopentose.

α-Glucosidase, bacillus stearothermophilus, is a carbohydrate enzyme that facilitates the release of α-glucose molecules. It retains exoglycosidase activity, enabling the hydrolysis of α-glycosidic bonds at the non-reducing ends of substrates.

Phosphoglucose isomerase, bacillus stearothermophilus, is a highly conserved glycolytic enzyme and dimerase. It catalyzes the isomerization of glucose-6-phosphate into fructose-6-phosphate.

Sphingomyelinphosphodiesterase, derived from Bacillus cereus, is a hydrolase enzyme involved in sphingomyelin metabolism. It catalyzes the hydrolysis of sphingomyelin into phosphocholine and ceramide. Additionally, sphingomyelinphosphodiesterase plays a crucial role in cell differentiation, various immune and inflammatory responses, and in the intracellular transport and metabolism of cholesterol.

endo-α-1,5-Arabinanase, Bacillus subtilis 168 (EC.3.2.1.99), is a glycoside hydrolase involved in the degradation of arabinans. The enzyme exo-α-1,5-Arabinanase is capable of cleaving the main chain of arabinans.

exo-α-Arabinofuranosidase, Bacillus subtilis (EC.3.2.1.55), is a glycoside hydrolase enzyme.

Exo-α-Arabinofuranosidase, Bacillus subtilis 168 (EC.3.2.1.55), is a glycoside hydrolase enzyme.

endo-α-1,5-Arabinanases, Paenibacillus polymyxa SC2 (EC.3.2.1.99), is a glycoside hydrolase involved in the degradation of arabinans. exo-α-1,5-Arabinanase can cleave the main chain of arabinans.

Glycosyltransferase-IN-1 is a glycosyltransferase inhibitor with bacteriostatic activity, inhibiting MSSA, MRSA, Bacillus subtilis, and Enterobacteriaceae.

Holomycin (N-Demethylthiolutin) is a secondary metabolite of dithiopyrrolidone. HolomycinHolomycin, an antibiotic secondary metabolite, is required for the biofilm formation of natural photogenic Bacillus galatheae S2753 and is also a broad-spectrum antibiotic. holomycin promotes biofilm formation of S2753 through its alene-disthionyl group. Holomycin has antitumor activity and is involved in RNA synthesis.

Polymyxin B Sulfate (Poly-RX) is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B Sulfate (Poly-RX) is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.

Colistin sulfate (Colistin sulfate (1066-17-7 free base)) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2.

Tribromsalan (3,5,4'-Tribromosalicylanilide) is an inhibitor of Mycobacterium tuberculosis and abscess bacillus, inhibiting IkappaBalpha phosphorylation to suppress NF-kappaB signaling.

1-Decanol inhibits various bacteria and fungi, including Candida albicans, Penicillium, Aspergillus niger, Bacillus subtilis, Propionibacterium, and others.

Colistin methanesulfonate sodium salt (Colistimethate Sodium) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2.

3,5-Dimethylbenzaldehyde has broad-spectrum antimicrobial activity, inhibiting Bacillus subtilis, Pseudomonas albicans, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae.

L-Norvaline is an arginase inhibitor and a non-protein branched-chain amino acid. L-Norvaline has previously been reported as a natural component of the antifungal peptide of Bacillus subtilis. L-Norvaline and other modified branched-chain amino acids have received attention in recent studies because they appear to be incorporated into some recombinant proteins found in E. coli.

Xanthosine is produced by guanine-free mutants of bacteria e.g. Bacillus subtilis, Aerobacter aerogenes. Xanthosine monophosphate is an intermediate in purine metabolism, formed from IMP, and forming GMP.

DL-Phenylalanine, a phenylalanine derivative, exhibits antifungal activity against Aspergillus flavus and antibacterial activity against Bacillus cereus and Escherichia coli.

(1R)-α-Pinene ((+)-alpha-Pinene) is a volatile substance from plants with antimicrobial activity and anthelmintic activity that reduces the growth of Bacillus cereus populations.

2-Methylcyclohexa-2,5-diene-1,4-dione exhibits inhibitory activity against cancer cells such as A2780, HT-29, HL-60, and K562 (IC50 = 2.8–12.1 µM) and antibacterial activity against Bacillus subtilis.