bacillus

Dalbavancin (BI-397), a novel second-generation lipoglycopeptide antibiotic, possesses in vitro activity against a variety of Gram-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE),Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively

Thioisonicotinamide (Isothionicotinamide) is a chemical based on the nicotinamide structure, but in which the amide is in the 4-position and not the 3-position.

Methyl carnosate is a diterpene compound with antioxidant and antimicrobial activity isolated from sage or rosemary.

Fraxidin is a coumarin compound isolated from the roots of Jatropha podagrica. It exhibits antibacterial activity against Bacillus subtilis, producing an inhibition zone of 12 mm in diameter at a concentration of 20 µg per disc.

Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones.

Bedaquiline (R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis.

Mycobacterium bovisbacterialprotein is a member of Mycobacterium tuberculosis, responsible for causing tuberculosis in cattle.

Sphingomyelinphosphodiesterase, derived from Bacillus cereus, is a hydrolase enzyme involved in sphingomyelin metabolism. It catalyzes the hydrolysis of sphingomyelin into phosphocholine and ceramide. Additionally, sphingomyelinphosphodiesterase plays a crucial role in cell differentiation, various immune and inflammatory responses, and in the intracellular transport and metabolism of cholesterol.

endo-α-1,5-Arabinanase, Bacillus subtilis 168 (EC.3.2.1.99), is a glycoside hydrolase involved in the degradation of arabinans. The enzyme exo-α-1,5-Arabinanase is capable of cleaving the main chain of arabinans.

Phosphoglucose isomerase, Bacillus subtilis (EC 5.3.1.9), is an essential enzyme involved in the interconversion between D-glucose-6-phosphate and D-fructose-6-phosphate. It catalyzes the second step of glycolysis and participates in glycogen synthesis. This enzyme is highly conserved across both bacteria and eukaryotes.

Trehalose-6-phosphate hydrolase, also known as Bacillus subtilis (EC 3.2.1.93), is part of the hydrolase enzyme family specializing in the hydrolysis of O- and S-glycosidic compounds. It plays a role in the metabolism of starch and sucrose. The substrates for this enzyme are α,α'-trehalose-6-phosphate and water, producing D-glucose and D-glucose-6-phosphate as products.

Xanthan lyase, Bacillus sp. (EC 4.2.2.12), is an enzyme that catalyzes the cleavage of β-D-mannosyl-β-D-1,4-glucuronic acid bonds in the polysaccharide xanthan. This enzyme is part of the family of lyases, specifically carbon-oxygen lyases that target polysaccharides.

β-Xylosidase, Bacillus subtilis (EC 3.2.1.37), is capable of releasing reducing sugars from birchwood xylan and also catalyzes the hydrolysis of 4-methylumbelliferyl-β-D-cellobioside and 4-methylumbelliferyl-β-D-xylopyranoside. This enzyme lacks endo-xylanase, arabinoxylanase, or β-glucanase activity. Furthermore, β-Xylosidase undergoes glycosylation modification after translation.

Thermitase, a protease from Bacillus cereus, is capable of inactivating RNAase, DNAase, and enzymes present in reactions.

exo-α-Arabinofuranosidase, Bacillus subtilis (EC.3.2.1.55), is a glycoside hydrolase enzyme.

Exo-α-Arabinofuranosidase, Bacillus subtilis 168 (EC.3.2.1.55), is a glycoside hydrolase enzyme.

Phosphotransacetylase, found in Bacillus subtilis (EC 2.3.1.8), catalyzes the conversion of coenzyme A to acetyl-CoA. As an acyltransferase, it transfers acyl groups other than aminoacyl groups. This enzyme is involved in three metabolic pathways: taurine and hypotaurine metabolism, pyruvate metabolism, and propanoate metabolism.

Cephalosporinase, bacillus, are enzymes produced by Bacillus; these enzymes inactivate and degrade the effectiveness of cephalosporin antibiotics. Cephalosporins are a class of β-lactam antibiotics widely used to treat bacterial infections [1].

Neutral Proteinase, derived from Bacillus sp., serves as a biocatalyst and is a pivotal enzyme in novel biocatalyst technology. Enzyme engineering focuses on improving reaction kinetics, substrate selectivity, and maintaining activity under challenging conditions (e.g., low or high pH). By incorporating stimuli-responsive modifications, dynamic control of enzyme activity can also be achieved.

Keratanase II, from Bacillus circulans and expressed in E. coli, possesses transglycosylation activity. It effectively catalyzes α(2→3)-sialylated 6,6′-di-sulfo-LacNAc with two glycosyl acceptors, 6-sulfo-Lewis X and 6,6'-di-sulfo-LacNAc derivatives, generating sialic acid sulfohexose and sialic acid sulfopentose.

α-Glucosidase, bacillus stearothermophilus, is a carbohydrate enzyme that facilitates the release of α-glucose molecules. It retains exoglycosidase activity, enabling the hydrolysis of α-glycosidic bonds at the non-reducing ends of substrates.

Phosphoglucose isomerase, bacillus stearothermophilus, is a highly conserved glycolytic enzyme and dimerase. It catalyzes the isomerization of glucose-6-phosphate into fructose-6-phosphate.

endo-α-1,5-Arabinanases, Paenibacillus polymyxa SC2 (EC.3.2.1.99), is a glycoside hydrolase involved in the degradation of arabinans. exo-α-1,5-Arabinanase can cleave the main chain of arabinans.

Neutral protease, Paenibacillus polymyxa is a neutral protease with strong fibronectinase and type IV collagenase activities. It can be used to separate intact epidermis from dermis and to detach intact epithelial sheets cultured in vitro from their substrates.