bacillus

Dalbavancin (BI-397), a novel second-generation lipoglycopeptide antibiotic, possesses in vitro activity against a variety of Gram-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE),Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively

Methyl carnosate is a diterpene compound with antioxidant and antimicrobial activity isolated from sage or rosemary.

Fraxidin is a class of coumarin. It is isolated from the roots of Jatropha podagrica. It also shows antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk.

Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones.

Bedaquiline (R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis.

Mycobacterium bovisbacterialprotein is a member of Mycobacterium tuberculosis, responsible for causing tuberculosis in cattle.

Sphingomyelinphosphodiesterase, derived from Bacillus cereus, is a hydrolase enzyme involved in sphingomyelin metabolism. It catalyzes the hydrolysis of sphingomyelin into phosphocholine and ceramide. Additionally, sphingomyelinphosphodiesterase plays a crucial role in cell differentiation, various immune and inflammatory responses, and in the intracellular transport and metabolism of cholesterol.

endo-α-1,5-Arabinanase, Bacillus subtilis 168 (EC.3.2.1.99), is a glycoside hydrolase involved in the degradation of arabinans. The enzyme exo-α-1,5-Arabinanase is capable of cleaving the main chain of arabinans.

exo-α-Arabinofuranosidase, Bacillus subtilis (EC.3.2.1.55), is a glycoside hydrolase enzyme.

Exo-α-Arabinofuranosidase, Bacillus subtilis 168 (EC.3.2.1.55), is a glycoside hydrolase enzyme.

Cephalosporinase, bacillus, are enzymes produced by Bacillus; these enzymes inactivate and degrade the effectiveness of cephalosporin antibiotics. Cephalosporins are a class of β-lactam antibiotics widely used to treat bacterial infections [1].

Neutral Proteinase, derived from Bacillus sp., serves as a biocatalyst and is a pivotal enzyme in novel biocatalyst technology. Enzyme engineering focuses on improving reaction kinetics, substrate selectivity, and maintaining activity under challenging conditions (e.g., low or high pH). By incorporating stimuli-responsive modifications, dynamic control of enzyme activity can also be achieved.

Keratanase II, from Bacillus circulans and expressed in E. coli, possesses transglycosylation activity. It effectively catalyzes α(2→3)-sialylated 6,6′-di-sulfo-LacNAc with two glycosyl acceptors, 6-sulfo-Lewis X and 6,6'-di-sulfo-LacNAc derivatives, generating sialic acid sulfohexose and sialic acid sulfopentose.

α-Glucosidase, bacillus stearothermophilus, is a carbohydrate enzyme that facilitates the release of α-glucose molecules. It retains exoglycosidase activity, enabling the hydrolysis of α-glycosidic bonds at the non-reducing ends of substrates.

Phosphoglucose isomerase, bacillus stearothermophilus, is a highly conserved glycolytic enzyme and dimerase. It catalyzes the isomerization of glucose-6-phosphate into fructose-6-phosphate.

Thioisonicotinamide (Isothionicotinamide) is a chemical based on the nicotinamide structure, but in which the amide is in the 4-position and not the 3-position.

endo-α-1,5-Arabinanases, Paenibacillus polymyxa SC2 (EC.3.2.1.99), is a glycoside hydrolase involved in the degradation of arabinans. exo-α-1,5-Arabinanase can cleave the main chain of arabinans.

Neutralprotease, Paenibacillus polymyxa (Dispase II, Dispase), is a neutral protease that effectively functions as a fibrinolysin and type IV collagenase. It is utilized to separate intact epidermis from dermis and to detach complete epithelial sheets from the matrix in cultures.

Aspoxicillin, a broad-spectrum antimicrobial agent, demonstrates efficacy against 68 isolates of Actinobacillus pleuropneumoniae, with a minimum inhibitory concentration (MIC90) of <= 0.05 μg/ml. It exhibits a prolonged half-life of 55 minutes in mouse serum.

Glycosyltransferase-IN-1 is a glycosyltransferase inhibitor with bacteriostatic activity, inhibiting MSSA, MRSA, Bacillus subtilis, and Enterobacteriaceae.

Holomycin (N-Demethylthiolutin) is a secondary metabolite of dithiopyrrolidone. HolomycinHolomycin, an antibiotic secondary metabolite, is required for the biofilm formation of natural photogenic Bacillus galatheae S2753 and is also a broad-spectrum antibiotic. holomycin promotes biofilm formation of S2753 through its alene-disthionyl group. Holomycin has antitumor activity and is involved in RNA synthesis.

Polymyxin B Sulfate (Poly-RX) is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B Sulfate (Poly-RX) is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.

Colistin sulfate (Colistin sulfate (1066-17-7 free base)) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2.

Tribromsalan (3,5,4'-Tribromosalicylanilide) is an inhibitor of Mycobacterium tuberculosis and abscess bacillus, inhibiting IkappaBalpha phosphorylation to suppress NF-kappaB signaling.