avibactam

Avibactam sodium (NXL-104) is a non-β-lactam β-lactamase inhibitor that inhibits TEM-1, P99, and KPC-2 β-lactamases (IC50=8 80 38 nM) covalently and reversibly. Avibactam sodium has antimicrobial activity and can be used to treat urinary tract infections.

Avibactam Tetrabutylammonium is the salt form of Avibactam.Avibactam is a non-β-lactam β-lactamase inhibitor that inhibits TEM-1, P99, and KPC-2 β-lactamases (IC50=8 80 38 nM) with covalent and reversible and can be used to treat urinary tract infections.

Avibactam (NXL-104) free acid is a covalent, reversible inhibitor of non-β-lactam β-lactamase, with IC50 values of 8 nM for β-lactamase TEM-1 and 5 nM for CTX-M-15.

Avibactam tomilopil (AV-006) is an orally bioavailable prodrug of Avibactam and functions as a β-lactamase inhibitor. Avibactam tomilopil effectively releases Avibactam, which inhibits class A and C β-lactamases, including extended-spectrum β-lactamases (ESBLs), AmpC enzymes, and Klebsiella pneumoniae carbapenemase (KPC), thereby broadening antibacterial coverage.

Avibactam sodium hydrate (NXL-104 hydrate) is a highly effective β-lactamase inhibitor that inhibits β-lactamases TEM-1 and CTX-M-15, as well as the carbapenemase produced by Klebsiella pneumoniae and carbapenem-resistant Enterobacteriaceae.

Avibactam sodium (NXL-104) dihydrate inhibits CTX-M-15 and β-lactamase TEM-1 with IC50 values of 5 nM and 8 nM, respectively, and is a reversible covalent inhibitor of non-β-lactam β-lactamase [1].

Avibactam sodium salt-13C5 is the 13C labeled compound of Avibactam sodium salt. Avibactam sodium salt has a CAS number of 1192491-61-4. Avibactam is a reversible β-lactamase inhibitor (IC50: 8 80 38 nM, for TEM-1 P99 KPC-2 β-lactamases).

FPI-1523, a derivative of Avibactam, is a potent inhibitor of β-lactamase enzymes with Kd values of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. It also inhibits PBP2 with an IC50 of 3.2 μM and demonstrates significant antimicrobial activity.

FPI-1523 sodium, a derivative of avibactam, is a potent β-lactamase inhibitor with Kd values of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. It inhibited PBP2 with an IC50 of 3.2 μM and has a high level of antibacterial and considerable antimicrobial activity.