asymmetric

UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.

Asymmetric dimethylarginine [an endogenous inhibitor of nitric oxide synthase (NOS)], is a compound that inhibits the enzyme responsible for producing nitric oxide.

Asymmetric dimethylarginine (Standard) is a reference standard for research and analysis in studies involving Asymmetric dimethylarginine. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS)

Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibulocydine rapidly blocked phosphorylation of the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase II, a process mediated by Cdk7/9. Anti-apoptotic gene products such as Mcl-1, survivin, and X-linked IAP (XIAP) are crucial for the survival of many cell types, including HCC. Following the inhibition of RNA polymerase II phosphorylation, ibulocydine caused rapid down-regulation of Mcl-1, survivin, and XIAP, thus inducing apoptosis. Furthermore, ibulocydine effectively ind......

Adma-D6 (Standard) is a reference standard of Adma-D6 intended for quantitative analysis, quality control, and related biochemical research applications. NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is used as an internal standard when quantitatively analyzing NG,NG-dimethyl-L-arginine by gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry. NG,NG-dimethyl-L-arginine is an endogenous inhibitor of nitric oxide synthase (NOS).

D-Lysine is the D-isomer of L-Lysine, prepared by chemical racemization and microbial asymmetric degradation of L-Lysine.D-Lysine reduces renal uptake of radiolabeled peptides and decreases nephrotoxicity.

7-Methoxy-1-naphthaleneacetic acid is an inhibitor of auxin action in plants. 7-Methoxy-1-naphthaleneacetic acid inhibits polar auxin transport and tropic responses associated with asymmetric auxin distribution in Arabidopsis and maize. 7-Methoxy-1-naphthaleneacetic acid inhibits auxin transport mediated by AUX1, PIN, and ABCB proteins expressed in yeast.

Gamma-Methylleucine (2-Amino-3-tert-butylpropionic acid) is an auxiliary for copper-catalyzed asymmetric Michael reactions.

NSC624206 (N-(2-((p-Chlorobenzyl)dithio)ethyl)decylamine hydrochloride) is an asymmetric disulfide small molecule that acts as a selective inhibitor of the ubiquitin-activating enzyme E1 (UBA1). It effectively blocks the in vitro ubiquitination-mediated degradation of the cell cycle regulator p27 and induces the accumulation of p27 protein in the HepG2 liver cancer cell model.

(R,R)-(+)-Hydrobenzoin is an o-diol compound with chiral configuration, which belongs to endogenous metabolites and is often used as chiral ligand or chiral auxiliary reagent in asymmetric synthesis to induce stereoselectivity. (R,R)-(+)-Hydrobenzoin rigid diphenyl glycol skeleton can form complexes with metal ions, which has important application value in catalysis and chiral recognition research.

MBS Crosslinker (MBS protein crosslinker) is a crosslinker that can be used as an asymmetric spacer.

Epoxide hydrolase, an enzyme responsible for catalyzing the reaction of epoxides with water to convert epoxy groups into diols, plays a crucial role in the metabolism of environmental pollutants and lipids. It is instrumental in detoxification, inflammatory responses, and regulating the health of the cardiovascular system. Additionally, Epoxide hydrolase is used in asymmetric catalytic reactions, such as the asymmetric ring-opening of epoxides, which are important for the synthesis of chiral pharmaceutical molecules.

C-MS023 is a photoactivatable prodrug of MS023, designed to achieve spatiotemporal inhibition of Histone Arginine Asymmetric Dimethylation. It specifically inhibits PRMT6-mediated asymmetric dimethylation of H3 Arginine 2 (H3R2me2a) with an IC50 of approximately 0.2224 μM. The photolysis of C-MS023 can be triggered by exposure to 420 nm visible light, releasing MS023, which effectively downregulates histone arginine asymmetric dimethylation and transcriptional activities related to DNA replication.

31hP is an asymmetric A3 lipid that enhances the expression of luciferase in vivo. It contains two ester bonds that are biodegradable, allowing for quick degradation by esterases. 31hP is also utilized in the synthesis of lipid nanoparticles (LNP).

PRMT1-IN-3 is a potent inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 of 4.11 μM. It also inhibits PRMT6 and PRMT8, with IC50 values of 23.3 and 30.1 μM, respectively. In triple-negative breast cancer (TNBC) cells, PRMT1-IN-3 reduces asymmetric dimethylarginine (ADMA) levels and the histone modification H4R3me2a. It induces cell cycle arrest and apoptosis in MDA-MB-231 cells and inhibits cell migration and colony formation. Furthermore, PRMT1-IN-3 serves as a chemosensitizer for Paclitaxel and is applicable in TNBC research.

SKLB06329 is a potent and selective inhibitor of type I PRMTs. It demonstrates strong selectivity for PRMT6 (IC50= 3.86 nM) without significantly inhibiting type II/III PRMTs (such as PRMT5/7) or various protein lysine methyltransferases [PKMTs]. SKLB06329 effectively suppresses the proliferation of triple-negative breast cancer [TNBC] cells, induces apoptosis, and inhibits the expression of asymmetric dimethylarginine [ADMA] within cells. This compound is applicable for research related to triple-negative breast cancer.

PROTAC PRMT1 degrader-1 (compound 4) is a PRMT1-targeting PROTAC degrader with an IC50 of 185.7 nM for human PRMT1. It recruits the CRBNE3 ubiquitin ligase, inducing proteasome-dependent degradation of PRMT1. Additionally, it forms a ternary complex with PRMT1 and CRBN, promoting PRMT1 ubiquitination followed by proteasomal degradation. This compound effectively reduces levels of asymmetrical dimethylarginine and asymmetrical dimethylation of histone H4 at arginine 3 in cancer cells while inhibiting the growth of various cancer cell lines. PROTAC PRMT1 degrader-1 is applicable in research on breast cancer and melanoma.

IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics[1].

Nb-enantride is a novel chiral trialkylborohydride for the asymmetric reduction of ketones.

L-Pyrohomoglutamic acid is an amino acid building block.1,2It has been used in the synthesis of ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors. 1.Pomplun, S., Wang, Y., Kirschner, A., et al.Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs)Angew. Chem. Int. Ed.54(1)345-348(2015) 2.Taddei, M., Cini, E., Giannotti, L., et al.Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitorsBioorg. Med. Chem. Lett.24(1)61-64(2014)

Potent and selective protein arginine methyltransferase 6 (PRMT6) inhibitor (IC50 = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric dimethylation of H3R2 (IC50 = 0.8 μM) Negative control SGC 6870N (Cat. No. 7184) also available.

1,3,3,5,5-pentamethylcyclohexan-1-amine hydrochloride, also known as PAC, is a cyclic amine commonly used as a chiral auxiliary in asymmetric syntheses including the Diels-Alder reaction, hydroxyaldol reaction, and Michael addition.

1-Stearoyl-2-myristoyl-sn-glycero-3-PC is an asymmetric phospholipid and a class of abundant lipid molecules in biological membrane systems.

UCB-6876 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins.