apterin

Apterin has anti-inflammatory activity in vitro, it shows significantly inhibitory activity on nitric oxide production in RAW264.7 cells.

Primapterin, 7-Substituted pterins, is a new type of mammalian pteridines.

Sarcinapterin is a coenzyme isolated from Methanosarcina barkeri.

L-Sepiapterin is an activator of phenylalanine hydroxylase and also a synthetic precursor of tetrahydrobiopterin, a cofactor of endothelial nitric oxide synthase. L-Sepiapterin can improve endothelial dysfunction in mesenteric arterioles of db/db mice and induce angiogenesis; meanwhile, L-Sepiapterin can also inhibit the proliferation and migration of ovarian cancer cells by downregulating p70S6K-dependent VEGFR-2 expression. Based on the above biological activities, L-Sepiapterin can be applied to mechanistic studies related to hyperphenylalaninemia.

6′′-O-β-D-Apiofuranosylapterin is a natural product for research related to life sciences. The catalog number is TN5875 and the CAS number is 2188162-94-7.

QM385 is a potent inhibitor of sepiapterin reductase (SPR)(IC50 of 1.49 nM).

SPR inhibitor 3 is a class of small-molecule compounds used to inhibit the activity of sepiapterin reductase; it blocks the biosynthetic pathway of tetrahydrobiopterin (BH4), thereby affecting the production of nitric oxide synthase and monoamine neurotransmitters.