apterin

Apterin has anti-inflammatory activity in vitro, it shows significantly inhibitory activity on nitric oxide production in RAW264.7 cells.

Primapterin, 7-Substituted pterins, is a new type of mammalian pteridines.

Sarcinapterin is a coenzyme isolated from Methanosarcina barkeri.

L-Sepiapterin, also known as Sepiapterin, is a precursor compound crucial for the production of tetrahydrobiopterin (BH4), which serves as a coenzyme for endothelial nitric oxide synthase (eNOS). This compound demonstrates its efficacy by improving endothelial dysfunction in small mesenteric arteries from db/db mice and promoting angiogenesis. Moreover, L-Sepiapterin exerts inhibitory effects on cellular proliferation and migration in ovarian cancer cells through the down-regulation of p70S6K-dependent vascular endothelial growth factor receptor-2 (VEGFR-2) expression[1][2].

6′′-O-β-D-Apiofuranosylapterin is a natural product for research related to life sciences. The catalog number is TN5875 and the CAS number is 2188162-94-7.

QM385 is a potent inhibitor of sepiapterin reductase (SPR)(IC50 of 1.49 nM).

SPR inhibitor 3 is an effective sepiapterin reductase inhibitor. SPR inhibitor 3 decreases neuropathic and inflammatory pain through a reduction of BH4 levels. SPR inhibitor 3 shows a high binding affinity to human SPR in a cell-free assay (IC50=74 nM) an