adrenic acid

Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) is a very-long-chain fatty acid present in blood and human myelin tissue.

Adrenic Acid (Standard) is a reference standard for research and analysis in studies involving Adrenic Acid. Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) is a member of the class of compounds known as very-long-chain fatty acids. Adrenic Acid can be found in blood and in human myelin tissue.

(±)10,11-EDT is an oxidized lipid and a metabolite of Adrenic acid.

(±)13,14-DiHDoTrE ((±)13,14-DHDT) is an oxidized lipid and serves as a metabolite of Adrenic acid.

1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid initially identified in sheep vesicular gland microsome extracts containing COX and incubated with adrenic acid. It has also been detected in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid. This compound is believed to be produced by the elongation of AA to adrenic acid, followed by sequential metabolism by COX and PGE synthase.

1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid containing stearic acid and adrenic acid at the sn-1 and sn-2 positions, respectively. Levels of 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE are inversely correlated with subject age in mitochondria isolated from human post-mortem hippocampus [1].

(±)13,14-EDT, an oxylipin metabolite derived from adrenic acid through the cytochrome P450 (CYP) pathway, acts as a potent activator of large-conductance calcium-activated potassium channels (KCa1.1/BK) in isolated rat coronary small arterial smooth muscle cells at 50 nM, promoting dilation. Additionally, it induces arteriole dilation in isolated porcine samples with an EC50 of 12 pM and relaxes isolated bovine coronary arteries previously contracted by TP receptor agonist U-46619.

(±)16,17-EDT, an oxylipin metabolite of adrenic acid produced through the cytochrome P450 (CYP) pathway, effectively induces dilation in isolated porcine arterioles (EC50 = 11 pM) and promotes relaxation of isolated bovine coronary arteries previously contracted by the TP receptor agonist U-46619.

1a,1b-Dihomo Prostaglandin F2α (1a,1b-dihomo PGF2α), a hypothetical product of adrenic acid in the COX pathway, is predominantly synthesized in the renal medulla, reflecting the selective distribution of adrenic acid in this region.

17(S)-HDoTE, a metabolite of adrenic acid, is synthesized through the action of 15-lipoxygenase (15-LO) via a 17-HpDoTE intermediate.

13,14-EDT is an oxylipin and a metabolite of adrenic acid, produced via the cytochrome P450 (CYP) pathway.

10,11-EDT, a substrate for soluble epoxide hydrolase (sEH), is a metabolic derivative of adrenic acid and acts as an endothelium-derived hyperpolarizing factor with potent vasorelaxant effects [1].