adjuvant

Incomplete Freund's adjuvant (IFA) is an emulsified mineral oil-based immunostimulant that induces Th2 responses and enhances immune reactions, promoting storage effects at vaccination sites.

Complete Freund's adjuvant (CFA) is an emulsified immunostimulant containing mineral oil and heat-killed mycobacteria, capable of inducing Th1 responses and enhancing immune reactions. It is frequently employed in establishing rat models of rheumatoid arthritis and persistent inflammatory pain.

BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displays no or very weak activity on the other P2X ion channels.

Platycoside E (Platycodin E) is a platycodigenin-type saponin isolated from the root of Platycodon grandiflorum with haemolytic activity and adjuvant potential.

NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1) at GABA(A) alpha subunit-containing receptors.

Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis.

Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a highly potent and selective MEK inhibitor that specifically inhibits MEK1/2 (IC50: 2 nM).

Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2].

Pristane (2,6,10,14-tetramethylpentadecane) is a natural product from shark liver oil and a non-antigenic adjuvant.

Antibioticadjuvant 2 (compound 5q) is a potent antibiotic adjuvant that enhances the efficacy of polymyxins and exhibits low toxicity in mammals. The minimum resensitization concentration of Antibioticadjuvant 2 for Escherichia coli AR-0493 is 0.125 μg/mL.

Antibioticadjuvant 3 (compound 8g) is an antibiotic adjuvant that significantly enhances the activity of polymyxins and exhibits low toxicity in mammals. It has a minimum resensitization concentration of 0.25 μg/mL against Escherichia coli AR-0493.

Aluminum hydroxideadjuvant is a vaccine adjuvant. In vitro, aluminum hydroxideadjuvant can induce macrophages to differentiate into a novel type of mature, specialized antigen-presenting cells.

Aluminum phosphate adjuvant is a safe and effective adjuvant that activates the immune system and associated pathways in monocytes.

Colistin adjuvant-2 is a compound that acts as a potentiation agent for colistin, effectively enhancing its activity against Gram-negative bacteria [1].

Colistin adjuvant-1 is a mucin adjuvant with enhanced mucin-enhancing activity against gram-negative bacteria. colistin adjuvant-1 exhibits inhibition of NF-κB (IC50: 0.209 μM).

Adjuvant-4 is a vaccine adjuvant that boosts antigen-specific antibody titers and cytotoxic T lymphocyte (CTL) responses. It typically functions as a water-in-oil emulsifier composed of mineral oil and sorbitan monooleate.

Vaccine adjuvant-1 is an adjuvant used in vaccines, consisting of an oil phase, an emulsifier, and water.

Antibioticadjuvant 1 (compound 3e) is an antibiotic adjuvant that exhibits insufficient antimicrobial activity on its own (MIC > 128 µg/mL), yet significantly enhances the effectiveness of Cloxacillin, boosting its activity by 66 times, demonstrating a synergistic effect.

Sodium lauryl sulfoacetate (Sodium houttuyfonate) is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.

Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for the adjuvant treatment of leukemia.

AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 could reverse complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 μM AITC in a concentration-dependent manner (IC50= 10.3 μM).

Iodofiltic acid can be used in the adjuvant treatment of acute coronary syndromes (Zeus ACS) and can be imaged to detect myocardial ischemia.

5-OP-RU is a MAIT-activating ligand, the major antigen of MAIT cells, a mucosal adjuvant, induces efficient enrichment of mucosal-associated invariant T cells, and can be used to study Mycobacterium tuberculosis infections.

Flunarizine dihydrochloride (R14950) is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine dihydrochloride (R14950) is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.