adjuvant

Complete Freund's adjuvant (CFA) is an emulsified immunostimulant containing mineral oil and heat-killed mycobacteria, capable of inducing Th1 responses and enhancing immune reactions. It is frequently employed in establishing rat models of rheumatoid arthritis and persistent inflammatory pain.

Adjuvant-4 is a vaccine adjuvant that boosts antigen-specific antibody titers and cytotoxic T lymphocyte (CTL) responses. It typically functions as a water-in-oil emulsifier composed of mineral oil and sorbitan monooleate.

Vaccine adjuvant-1 is an adjuvant used in vaccines, consisting of an oil phase, an emulsifier, and water.

Vitamin E succinate (D-alpha-Tocopherol Succinate) is an antioxidant tocopherol that belongs to the vitamin E class of compounds Vitamin E succinate has antitumor activity, induces apoptosis, and is used as an adjuvant in the treatment of cancer and in the synthesis of INVITE, a biocoupling compound.

DSPE-PEG(2000)-mannose, a pegylated and mannosylated derivative of 1,2-DSPE, has been employed in both in vitro and in vivo studies for delivering peptides, oligodeoxynucleotides, and siRNA via liposomes and lipid nanoparticles (LNPs). Fluorescently labeled LNPs containing DSPE-PEG(2000)-mannose predominantly accumulate in the liver and spleen of mice, significantly more so than in the brain, lungs, heart, kidneys, and pancreas. In immunization studies, liposomes encapsulating Human Papillomavirus type 16 (HPV16) E7 peptides with CpG oligodeoxynucleotides as an adjuvant led to reduced tumor volume and decreased numbers of CD4+ or CD8+ T cells and angiogenesis within tumors in a mouse lung cancer model using TC-1 cells.

Dihydrotestosterone-KLH is a hapten-carrier protein conjugate formed by coupling Dihydrotestosterone (DHT) to keyhole limpet hemocyanin (KLH). As a hapten, Diethylstilbestrol alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. Dihydrotestosterone-KLH may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M TBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% (Ditiocarb sodium trihydrate, ACS, 99.0%), is a copper reagent that reacts with Cu2+ solutions to form complexes, enhancing the rate of copper precipitation. Additionally, it has potential in reducing HIV infection and is employed in adjuvant immune research for high-risk breast cancer.

Vaxfectin is a lipid adjuvant used in the development of protein and peptide vaccines.Vaxfectin promotes vaccine immunogenicity.

16:0 EPC chloride, a saturated cationic lipid and a P-O-ethyl derivative, functions as a DNA and RNA transfecting agent. It is also utilized as a co-adjuvant in vaccine preparation and to enhance drug delivery [1].

Potassium alum (Aluminum potassium sulfate dodecahydrate) is an ovalbumin adjuvant that can be used to induce allergic reactions in mice, used in cell culture, and suitable for bacterial staining.

3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) is a TLR agonist that can serve as an adjuvant in vaccines to enhance their immunogenicity.

RIBI-529 (RC-529) is a lipid A analogue (aminoalkyl glucosaminide 4-phosphate) that acts as an adjuvant with potency similar to MPL (Corixa). It signals through Toll-like receptor 4 to activate the innate immune system.

VC1052 is a component of Vaxfectin. Vaxfectin is a cationic lipid adjuvant used for vaccines based on plasmid DNA and proteins.

Sucrose Monododecanoate is a sugar-based surfactant, which can be used as mucosal adjuvant.

Poloxamer 401 L121 is a block copolymer composed of polyoxyethylene and polyoxypropylene. It is utilized in nanoparticle engineering as a lymphocyte nutrition particle, an inhibitor of multidrug resistance and adjuvant activity, or in the cosmetics industry as a surfactant and emulsifier.

Acedoben sodium is the sodium salt form of Acedoben. Acedoben can rapidly form a self-assembling coordination complex with iron ions, and this Fe-Ace coordination complex not only serves as a carrier for tumor antigens but also enhances antigen-specific antitumor immunity due to its intrinsic adjuvant properties.

Ethambutol-KLH is a hapten-carrier protein conjugate formed by linking ethambutol to KLH (kalnex lymphocyte histidine-containing leukocyte antigen). It enhances the immune response induced by Ethambutol through hapten-protein adjuvant binding and is commonly used in vaccine or antibody preparation studies.

Rifampin-BSA is a hapten-carrier protein conjugate formed by binding Rifampin to BSA (bovine serum albumin). It enhances Rifampin-induced immune responses by combining a hapten with a protein adjuvant, commonly used in vaccine or antibody preparation studies.

Ethambutol-BSA is a hapten-carrier protein conjugate formed by linking ethambutol to BSA (bovine serum albumin). It enhances the immune response induced by Ethambutol by combining a hapten with a protein adjuvant and is commonly used in vaccine or antibody studies.

Digoxin-BSA is an antigen–adjuvant conjugate composed of Digoxin covalently linked to bovine serum albumin (BSA), designed to enhance the production of antigen-specific antibodies in vaccine and immunological models, while preserving native protein folding and major epitopes, improving cross-presentation efficiency, and promoting robust antigen-specific T-cell responses for immunogenicity and antibody development research.

Isoniazid-BSA is a hapten-carrier protein conjugate formed by binding isoniazid to BSA (bovine serum albumin). It enhances isoniazid-induced immune responses by combining a hapten with a protein adjuvant, commonly used in vaccine or antibody preparation research.

This product is an antigen-adjuvant conjugate that consists of Morphin linked with bovine serum albumin (BSA). By conjugating the antigen with a protein adjuvant, it enhances the production of antigen-specific antibodies in vaccine models. The conjugate does not alter protein folding or disrupt key epitopes, and it enhances cross-presentation and the generation of antigen-specific T cells.

VSA 2 is a saponin-based vaccine adjuvant and a derivative of Momordica saponin (MS) II. As an immune stimulant, VSA 2 consistently enhances the production of immunoglobulin G2a (IgG2a) when formulated with either ovalbumin or recombinant hemagglutinin B (rHagB) antigens.

4A-MPLA (ammonium) serves as an adjuvant in vaccines, capable of inducing tissue-specific immune responses. It enhances the host's resistance to endotoxin-induced effects and reduces cytokine production during infections.