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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13410 | ZLDI-8 | Apoptosis , Phosphatase , Gamma-secretase , Immunology/Inflammation related | |
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein. | |||
T9657 | FiVe1 | Others | |
FiVe1 is a vimentin binding small molecule that promotes the disintegration and phosphorylation of vimentin in the metaphase, leading to mitotic disasters, polynuclearization, and loss of cancer cell dryness. FiVe1 selec... | |||
T61746 | Anticancer agent 82 | ||
Anticancer agent 82 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin ( VIM ), to induce hyperphosphorylation of Ser56, resulting selectiv... | |||
T75491 | 3-(2-Hydroxyethyl) thio withaferin A | ||
3-(2-Hydroxyethyl) thio withaferin A, a derivative of Withaferin A, is a steroidal lactone that inhibits NF-kB activation and targets vimentin, showcasing potent anti-inflammatory and anticancer properties. It also acts ... | |||
T82006 | JM3A | ||
JM3A, a highly specific peptoid reagent, selectively targets cell surface vimentin (CSV) on early lung cancer cells undergoing tumor transformation. By conjugating with fluorophores [1], JM3A detects and stains CSV, enab... | |||
T22036 | Arylquin 1 | ||
Arylquin 1, a prostate-apoptosis-response-4 (Par-4) secretagogue, specifically targets vimentin to facilitate Par-4 secretion. Additionally, it promotes non-apoptotic cell death in cancer cells by inducing lysosomal memb... | |||
T81400 | Pritumumab | ||
Pritumumab, a natural human IgG1kappa monoclonal antibody (mAb), was first isolated from the regional draining lymph node of a cervical carcinoma patient. It specifically recognizes cell-surface-expressed vimentin on mal... |