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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T38078 | TLR7/8-IN-1 | TLR7/8-IN-1 | TLR |
TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research[1]. | |||
T39669 | TLR7/8/9-IN-1 | TLR7/8/9-IN-1 | TLR |
TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM. | |||
T6964 | Resiquimod | R848,S28463 | HCV Protease , TLR |
Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and acti... | |||
T79068 | TLR7/8 agonist 8 | ||
TLR7/8 agonist 8 (compound 24m) is a potent dual agonist for toll-like receptors 7 and 8 (TLR7/8), exhibiting half-maximal effective concentrations (EC50s) of 27 nM for human TLR7 (hTLR7) and 12 nM for human TLR8 (hTLR8)... | |||
T61601 | TLR7/8 antagonist 2 | ||
TLR7/8 antagonist 2 (Compound 15) is a highly potent and orally active agonist of TLR7/8, exhibiting IC50 values of 4.9 and 0.6 nM for TLR7 and TLR8, respectively. Its strong affinity for these receptors makes it a promi... | |||
T62178 | TLR7/8 antagonist 1 | ||
TLR7/8 Antagonist 1 (Compound 16c), an imidazoquinoline derivative, is a potent TLR7/8 agonist with IC50 values of 3.91 and 2.19 μM for TLR7 and TLR8, respectively. rel-O-2050 (TLR-2050) is a key target for drug developm... | |||
T74348 | HE-S2 | PD-1/PD-L1 | |
HE-S2, an antibody-drug conjugate, elicits a potent antitumor immune response by inhibiting the PD-1/PD-L1 interaction and stimulating the Toll-like receptor 7/8 (TLR7/8) signaling pathway, resulting in significant antit... | |||
T14035 | 3M-011 | TLR | |
3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibit... | |||
T79069 | TLR7/8 agonist 9 | ||
TLR7/8 agonist 9 (Compound 25a), exhibiting EC50 values of 40 nM and 23 nM for hTLR7 and hTLR8 respectively, demonstrates anti-tumor properties and enhances the efficacy of PD-1/PD-L1 blockade treatments. This compound i... | |||
T37287 | Enpatoran hydrochloride | ||
Enpatoran (M5049) hydrochloride is a potent and orally active dual inhibitor of TLR7/8 with IC50 values of 11.1 nM and 24.1 nM in HEK293 cells, respectively. This compound specifically inhibits TLR7 and TLR8, while showi... | |||
T83895 | NCI 126224 | NSC 126224 | |
NCI 126224, a toll-like receptor 4 (TLR4) antagonist, demonstrates selective inhibition of nitric oxide (NO) production in RAW 264.7 macrophages, triggered by the TLR4 agonist LPS (IC50 = 0.31 µM), as opposed to minimal ... |