T8003

Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor

Oxyntomodulin (bovine, porcine) TFA is a 37-amino acid peptide hormone that functions as a glucagon-like peptide 1 (GLP-1) receptor agonist [1].

[D-Pro2] Spantide I TFA is an analog of Spantide I, serving as a selective antagonist of the NK1 receptor [1].

FITC-α-Bungarotoxin is the FITC-labeled form of α-Bungarotoxin, which acts as a competitive antagonist at nicotinic acetylcholine receptors (nAChRs) [1].

Biotin-α-Bungarotoxin is a biotinylated form of α-Bungarotoxin, which acts as a competitive antagonist at nicotinic acetylcholine receptors (nAChRs) [1].

Margatoxin TFA, an alpha-KTx scorpion toxin isolated from Centruroides margaritatus venom, is a 39-amino-acid peptide that serves as a high-affinity inhibitor of Kv1.3 (Kd = 11.7 pM). It also inhibits Kv1.2 (Kd = 6.4 pM) and Kv1.1 (Kd = 4.2 nM), making it a valuable tool for ion channel research [1] [2].

Biotin-β-Amyloid (1-42), human TFA, also known as Biotin-Amyloid β-Peptide (1-42) (human) TFA, is a biotin-labeled 42-amino acid peptide implicated in the pathogenesis of Alzheimer's disease.

AmmTX3 TFA, a peptide toxin derived from Androctonus mauretanicus scorpion venom, functions as a selective blocker of the K_v4 channel. It inhibits the A-type K^+ current with an inhibition constant (K_i) of 131 nM [1] [2].

Bim BH3 is a bioactive peptide that belongs to the pro-apoptotic Bcl-2 family of proteins.

ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked to pulmonary vein arrhythmogenesis and atrial fibrillation [1] [2]. It exhibits interaction with halothane, caffeine, and ryanodine.

Methotrexate-D3 diammonium is the deuterated form of Methotrexate diammonium (T8003). Methotrexate (Amethopterin) functions as an antimetabolite and antifolate by inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, thereby inhibiting DNA synthesis. It also acts as an immunosuppressant and antineoplastic agent, used in treating rheumatoid arthritis and in researching various cancers, such as acute lymphoblastic leukemia.