T6066

SCH772984 is an ERK inhibitor that inhibits ERK1 and ERK2 (IC50=4/1 nM) and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity against BRAF or RAS mutant cells.

MAO-B-IN-14 (Compound 9) is a potent and selective monoamine oxidase-B (MAO-B) inhibitor, exhibiting an IC50 of 0.95 μM and a Ki of 0.55 μM for human MAO-B.

CP681301 is a highly potent and specific small molecule inhibitor of CDK5 with an inhibition constant (Ki) of 13.7 nM for CDK5. CP681301 not only completely blocks the kinase activity of CDK5-p35 and CDK5-p25 complexes but also effectively inhibits the expression of stem cell markers (such as SOX2, OLIG2) and the self-renewal capacity of tumor cells in glioma stem cell models, demonstrating anti-tumor proliferative activity.

MS117 is a first-in-class, cell-active, irreversible covalent inhibitor of protein arginine methyltransferase 6 (PRMT6) with an IC50 of 18 nM [1].

Oseltamivir acid methyl ester is a precursor form of oseltamivir acid, which is converted to oseltamivir acid by carboxylesterase 1 (CES1). Oseltamivir acid, in turn, acts as a neuraminidase inhibitor and antiviral agent [1].

Magnesium salicylate relieves minor aches and pains temporarily which is an orally active analgesic [1].

Antibacterial agent 105 (Compound 17), a phenanthrolinic analog of quinolones, exhibits antibacterial activity against M. tuberculosis with an MIC 90 of 2.64 μM. Additionally, it displays activity against M. smegmatis, M. aurum, M. marinum, BCG, E. aerogenes, and S. aureus with MIC 90 values of 11.18, 11.18, 0.70, 1.40, 44.70, and 22.35 μM, respectively [1].

NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels and induces subsequent metabolic and transcriptional reprogramming. It exhibits neuroprotective effects in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model and may be employed in studies of neurodegenerative diseases or conditions associated with reduced NAD levels.

MAT2A inhibitor 3 can be used in the cancer research. MAT2A inhibitor 3 is a inhibitor of methionine adenosyltransferase 2A (MAT2A) with an IC 50 of <200 nM [1].

Enpp-1-IN-10 (compound 1) is a potent inhibitor of Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) with a Ki value of 3.866 μM, suitable for anticancer research [1].