T4043

ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor that inhibits β-catenin reporter activity with an IC50 of 2.9 nM.

Cetirizine Impurity D is an impurity of Cetirizine, a second-generation antihistamine that functions as a specific, orally active, and long-acting antagonist of the histamine H1-receptor [histamine H1-receptor]. Cetirizine exhibits antiallergic properties and inhibits eosinophil chemotaxis in response to allergies.

Anabaseine is a non-selective nicotinic agonist that stimulates all alpha-7 subtypes of AChRs, with a preference for those in skeletal muscle and the brain. Additionally, it acts as a weak partial agonist at alpha-4 beta-2 [nAChRs].

6-Azido-hexylamine is an azide and a degradable ADC linker that can be used to synthesize anti-ADC compounds.

Chlorin e6 trimethyl ester, a derivative of methyl pheophorbide-a, is an effective photosensitizer for photodynamic therapy (PDT).

N,N'-Diacetylchitobiose is a chitin di-sugar and lysozyme inhibitor. It can serve as the sole carbon source for wild-type Escherichia coli and can reverse myocardial inhibition in canine Escherichia coli sepsis.

Caloxin 2A1 is an inhibitor peptide of the plasma membrane Ca 2+-ATPase (PMCA) responsible for extracellular signaling. Importantly, Caloxin 2A1 has no impact on the basal Mg 2+-ATPase or Na+-K+-ATPase activities.

Caloxin 2A1 acetate is an inhibitor of extracellular plasma membrane Ca2+-ATPase (PMCA) peptide. Caloxin 2A1 acetate inhibits Ca2+-dependent formation of the 140-kDa acid-stable acylphosphate.

Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.