T3903

Angoroside C is a Potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxidative activity in reducing the oxidized OH adducts of dAMP and dGMP. Reveals some trypanocidal potential.

HBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.HBDDE is a derivative of ellagic acid, which induces apoptosis in neuronal cells. HBDDE is a derivative of ellagic acid and induces apoptosis in neuronal cells.

FSCPX is a potent and selective irreversible antagonist of the A1 adenosine receptor (A1AR), exhibiting low nanomolar binding potency. It can effectively decrease the interstitial adenosine level in the guinea pig atrium, thereby modifying the effect of [NBTI], a nucleoside transport inhibitor.

Olmesartan impurity, a compound related to Olmesartan, is an angiotensin II receptor (AT1R) antagonist utilized in the study of high blood pressure. Olmesartan (RNH-6270) is the parent compound with similar properties and functions as an AT1R antagonist.

Pomalidomide-5-O-CH3, a derivative of Pomalidomide, serves as a specific ligand for cereblon (CRBN) protein recruitment. It can be linked to the protein ligand to create a PROTAC.

Pomalidomide-6-O-CH3 is a Pomalidomide-derived ligand for cereblon (CRBN), which serves as a linkage agent to recruit the CRBN protein. This ligand, when connected to a protein via a linker, enables the formation of PROTAC.

PEG2-ethyl acetate, a PEG-based linker for PROTACs, facilitates the formation of PROTAC molecules by joining two essential ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

FXIa-IN-6 is a potent FXIa inhibitor with selectivity against most relevant serine proteases (K_i = 0.3 nM), demonstrating excellent pharmacokinetics (PK) profile, including high oral bioavailability and low clearance, in multiple preclinical species.

(3R,5S)-Fluvastatin, the 3R,5S-isomer of Fluvastatin (XU 62-320 free acid), stands as the inaugural fully synthetic, competitive inhibitor of HMG-CoA reductase, exhibiting an IC50 value of 8 nM. It safeguards vascular smooth muscle cells from oxidative stress by activating the Nrf2-dependent antioxidant pathway.

Tiludronate (Tiludronic Acid) disodium hemihydrate is an orally active bisphosphonate compound used primarily in metabolic bone disorder research. It functions as an osteoregulator and acts as a potent inhibitor of the osteoclast vacuolar H+ -ATPase, possessing antiresorptive and anti-inflammatory properties [4].

RORγt inhibitor 1 is an RORγt allosteric inhibitor with an IC50 value of 1 nM.