T2078

Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types.

Maleic hydrazide is a plant growth regulator and germination inhibitor that participates in nucleic acid metabolism pathways within plants, thereby inhibiting cell division in the apical meristem.

Diethyl malate is a succinate ester suitable for biochemical experiments and drug synthesis research.

S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.

Fluconazole-PEG6-XMU-MP-9 is a PEG-linked conjugate of fluconazole and XMU-MP-9. Fluconazole is a triazole antifungal agent, while XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, promoting the ubiquitination and degradation of multiple K-Ras mutants.

Fluconazole-C15-XMU-MP-9 is a fluconazole derivative modified with XMU-MP-9, which enhances the interaction between Nedd4-1 and K-Ras, promoting the ubiquitination and degradation of multiple K-Ras mutants, demonstrating anticancer potential. Fluconazole is an antifungal agent.

I3MITC-Cys is a Cys-modified I3M ITC (I3M-isothiocyanate) suitable for biochemical experiments and drug synthesis research.

SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor).

SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.

Tryptophan-cholic acid (Trp-CA) is a microbial amino acid-binding bile acid (MABA), serving as an endogenous ligand and agonist for MRGPRE (Mas-related GPCR family member E), thereby inducing GLP-1 secretion. Tryptophan-cholic acid improves glucose tolerance in diabetic mice and may be utilised for studies on type 2 diabetes.

5-OH-Dpat is a selective and bivalent dopamine receptor D2/D3 agonist exhibiting EC50 values of 41 nM and 0.63 nM respectively in [35S]GTPγS functional assays. It is applicable for investigating neurodegenerative disorders such as Parkinson's disease.

Choline-d9 chloride is a deuterium-labelled derivative of choline chloride for isotope tracing. Choline chloride, an essential nutrient, activates α7 nicotinic acetylcholine receptors and exhibits anti-inflammatory and analgesic properties.

SKLB-03220 is an orally bioavailable covalent inhibitor targeting the histone methyltransferase EZH2, an established oncology drug target involved in epigenetic regulation. SKLB-03220 is structurally based on the clinically approved EZH2 inhibitor tazemetostat and demonstrates the ability to abolish epigenetic H3K27me3 marks, thereby altering chromatin state and transcriptional activity. SKLB-03220 represents a potent small-molecule tool for cancer epigenetics research.

TEAD1/3/4-IN-1 (compound 1) is an inhibitor of TEAD1/3/4 that suppresses YAP/TAZ-TEAD interactions. It exhibits antitumour activity against NF2-deficient NCI-H226 cells and may be employed in studies of cancer and diseases mediated by Hippo pathway abnormalities.

2-Cyclohexylethylamine Hydrochloride exhibits inhibitory activity against carbonic anhydrase, suitable for biochemical experiments and drug synthesis research.

Ethyl 2,4-dihydroxybenzoate is a benzoic acid ester suitable for biochemical experiments and drug synthesis research.

IRAK4 modulator-2 (Compound 5) is a selective dual inhibitor of IRAK4 and IRAK1, with IC₅₀ values of 0.005 μM and 0.97 μM respectively. It may be employed in research concerning autoimmune and inflammatory diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

2-Pyridinamine, 4-[3-fluoro-5-(4-morpholinyl)phenyl] (Compound 9l) is an ATP-competitive JNK (c-Jun N-terminal kinase) inhibitor with IC₅₀ values of 0.099 μM and 0.148 μM for JNK1 and JNK3 respectively, exhibiting the advantage of blood-brain barrier penetration. 2-Pyridinamine, 4-[3-fluoro-5-(4-morpholinyl)phenyl] inhibits c-Jun phosphorylation and reactive oxygen species (ROS) generation, making it suitable for neurodegenerative disease research.

Deoxycholic acid 3-sulfate is a sulphonated bile acid and endogenous metabolite, suitable for biochemical experiments and drug synthesis research.

6-trans-Leukotriene B4 is a neutrophil chemotactic agent present in guinea pig dermis.