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Search Result

Search Results for " sik "

Targets

SIK SIK

20

Compounds

4

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T4599 HG-9-91-01 SIK inhibitor 1 SIK
HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3respectively.
T17271 YKL-05-099 SIK
YKL-05-099 is an inhibitor of the salt-inducible kinase(SIK1 and SIK3 ; IC50s: 10 and 30 nM, respectively). It has a slightly less potent SIK2-inhibitory (IC50:40 nM).
T9219 WH-4-025 AMPK , SIK
WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
T5576 YKL-06-061 AMPK , SIK
YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.
T5993 ARN-3236 AMPK , SIK
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively). ARN-3236 Has anti-cancer activity.
T4327 Prexasertib dihydrochloride LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368 Apoptosis , Chk , S6 Kinase
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.
T4310 Prexasertib LY2606368 Apoptosis , Chk
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
T78762 SIKs-IN-1
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2 macrophage polarization linked to inflammation. By inhibiting SIK...
T78196 SIK2-IN-1
SIK2-IN-1 (compound 8g) is a potent inhibitor of SIK2 with selectivity over other AMPK-family kinases, demonstrating favorable ADMET profiles in vitro and robust cellular activities [1].
T61992 SIK1 activator 1
SIK1 activator 1 can enhances the SIK1 phosphorylation and ameliorated the hyperglyceamia of type 2 diabetic mice. SIK1 activator 1 exhibited remarkable inhibitory activity on hepatic gluconeogenesis.
T1811 WH-4-023 KIN112,KIN001-112,Dual LCK/SRC inhibitor Src
WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK.
T17272 YKL-06-062 SIK
YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that inhibits SIK1, SIK2 and SIK3 with IC50s of 2.12 nM, 1.40 nM and 2.86 nM.
TP1760L AMARA peptide acetate(163560-19-8 free base) Others
AMARA peptide acetate is a substrate for SIK and AMPK.AMARA peptide is a minimal substrate of several members of the protein kinases family. It consists of the phosphorylation site for AMP-activated Protein Kinase (AMPK)...
T36891 MRIA9
MRIA9, an ATP-competitive inhibitor targeting pan Salt-Inducible Kinases (SIK) and PAK2/3, demonstrates IC50 values of 516 nM, 180 nM, and 127 nM for SIK1, SIK2, and SIK3, respectively [1].
T75984 AMARA peptide TFA
AMARA peptide (TFA) serves as a substrate for both salt-inducible kinase (SIK) and adenosine monophosphate-activated protein kinase (AMPK).
TP1314 AMARA peptide TFA (163560-19-8 free base) AMARA peptide TFA
AMARA peptide (TFA) is a substrate for salt-induced kinase (SIK) and adenosine activated protein kinase (AMPK).
T69837 YKL-05-093
YKL-05-093 is a alt inducible kinase (SIK) inhibitor. YKL-05-093 increases bone formation and bone mass.
T16142 MRT199665 Others
MRT199665 is an effective and ATP-competitive, selective MARK/SIK/AMPK inhibitor (IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively). MRT199665 ...
TP1760 AMARA peptide
AMARA peptide is a substrate for SIK and AMPK.AMARA peptide is a minimal substrate of several members of the protein kinases family. It consists of the phosphorylation site for AMP-activated Protein Kinase (AMPK).
T23028 MRT67307 HCl (1190378-57-4 free base) MRT67307 HCl Others
MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it i...
Cat No. Product Name Synonyms Targets
TN5830 Campsiketalin Rengyoxide dimethyl ketal
Campsiketalin is a natural product for research related to life sciences. The catalog number is TN5830 and the CAS number is 93675-96-8.
TN5021 Sikokianin C
Sikokianin C is a biflavonoid isolated from Wikstroemia sikokiana.Sikokianin C is a selective cystathionine β-synthase inhibitor with antitumour activity for the treatment of human colon cancer.
T81156 Sikokianin E
Sikokianin E, a biflavonone derivative, is isolable from Coreopsis tinctoria [1].
TN6420 Sikokianin A
Sikokianin A shows in vitro antiviral activity against HBsAg secretion.

Natural Products

Campsiketalin
TN5830
Synonym: Rengyoxide dimethyl ketal
Target:
Sikokianin C
TN5021
Synonym:
Target:
Sikokianin E
T81156
Synonym:
Target:
Sikokianin A
TN6420
Synonym:
Target:

Recombinant Proteins

Species：
Mouse (1)
Expression System：
Baculovirus-Insect Cells (1)
Tag：
His,GST (1)
Cat No. Product Name Species Expression System
TMPY-04440 Brk Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
Tyrosine kinase (PTKs) is a protein that carries out tyrosine phosphorylation, which play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been demonstrated to mediate malignant ce...
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