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  • AMPK
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  • Apoptosis
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Results for "

SIK

" in TargetMol Product Catalog
  • Inhibitor Products
    20
    TargetMol | Activity
  • Peptides Products
    4
    TargetMol | inventory
  • Recombinant Protein
    2
    TargetMol | natural
HG-9-91-01
T45991456858-58-4
HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3respectively.
  • $76
In Stock
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TargetMol | Citations Cited
SIK2-IN-1
T78196
SIK2-IN-1 (compound 8g) is a potent inhibitor of SIK2 with selectivity over other AMPK-family kinases, demonstrating favorable ADMET profiles in vitro and robust cellular activities [1].
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SIK1 activator 1
T619922769850-83-9
SIK1 activator 1 can enhances the SIK1 phosphorylation and ameliorated the hyperglyceamia of type 2 diabetic mice. SIK1 activator 1 exhibited remarkable inhibitory activity on hepatic gluconeogenesis.
  • Inquiry Price
10-14 weeks
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YKL-05-099
T172711936529-65-5
YKL-05-099 is an inhibitor of the salt-inducible kinase(SIK1 and SIK3 ; IC50s: 10 and 30 nM, respectively). It has a slightly less potent SIK2-inhibitory (IC50:40 nM).
  • $68
In Stock
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
AMARA peptide acetate(163560-19-8 free base)
TP1760L
AMARA peptide acetate is a substrate for SIK and AMPK.AMARA peptide is a minimal substrate of several members of the protein kinases family. It consists of the phosphorylation site for AMP-activated Protein Kinase (AMPK).
  • $78
In Stock
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MRT199665
T161421456858-57-3In house
MRT199665 is an effective and ATP-competitive, selective MARK/SIK/AMPK inhibitor (IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively). MRT199665 suppresses the phosphorylation of S
  • $1,520
8-10 weeks
Size
QTY
TargetMol | Inhibitor Sale
YKL-06-062
T172722172617-16-0In house
YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that inhibits SIK1, SIK2 and SIK3 with IC50s of 2.12 nM, 1.40 nM and 2.86 nM.
  • $93
In Stock
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ARN-3236
T59931613710-01-2
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively). ARN-3236 Has anti-cancer activity.
  • $55
In Stock
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TargetMol | Citations Cited
AMARA peptide
TP1760163560-19-8
AMARA peptide is a substrate for SIK and AMPK.AMARA peptide is a minimal substrate of several members of the protein kinases family. It consists of the phosphorylation site for AMP-activated Protein Kinase (AMPK).
  • $63
Backorder
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TargetMol | Inhibitor Sale
Prexasertib dihydrochloride
T43271234015-54-3
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.
  • $38
In Stock
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WH-4-025
T92191876463-35-2
WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
  • $34
In Stock
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TargetMol | Inhibitor Sale
WH-4-023
T1811837422-57-8
WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK.
  • $47
In Stock
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MRIA9
T368912750707-05-0
MRIA9, an ATP-competitive inhibitor targeting pan Salt-Inducible Kinases (SIK) and PAK2/3, demonstrates IC50 values of 516 nM, 180 nM, and 127 nM for SIK1, SIK2, and SIK3, respectively [1].
  • $598
Backorder
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SIKs-IN-1
T787622927557-06-8
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2 macrophage polarization linked to inflammation. By inhibiting SIK activity, this compound increases the anti-inflammatory cytokine IL-10 and decreases the pro-inflammatory cytokine IL-12, demonstrating significant anti-inflammatory efficacy in a DSS-induced colitis model [1].
  • $1,520
6-8 weeks
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MRT67307 HCl (1190378-57-4 free base)
T23028
MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.
SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and other anti-inflammatory molecules. IKKε and TBK-1 mediate the phosphorylation of interferon regulatory factor 3 (IRF3). MARK1 is a Serine/threonine-protein kinase.
In macrophages, MRT67307 prevented the production of IFNβ and the phosphorylation of IRF3 without suppressing the activation of NF-κB, which showed that MRT67307 blocked the induction of Pellino 1 through inhibiting TBK1/IKKε kinase activity [1] [3]. Also, MRT67307 completely blocked the TBK1- or IKKε-induced decrease in the mobility of Pellino 1 [3]. Exposed macrophages to MRT67307 increased the levels of the anti-inflammatory cytokines IL-1ra and IL-10 and decreased the levels of proinflammatory cytokines (such as IL-6, IL-12, and TNF) in response to bacterial lipopolysaccharide (LPS) [4].
  • $74
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AMARA peptide TFA (163560-19-8 free base)
TP1314
AMARA peptide (TFA) is a substrate for salt-induced kinase (SIK) and adenosine activated protein kinase (AMPK).
  • $63
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YKL-05-093
T698372172616-44-1
YKL-05-093 is a alt inducible kinase (SIK) inhibitor. YKL-05-093 increases bone formation and bone mass.
  • $2,270
10-14 weeks
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AMARA peptide TFA
T75984
AMARA peptide (TFA) serves as a substrate for both salt-inducible kinase (SIK) and adenosine monophosphate-activated protein kinase (AMPK).
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YKL-06-061
T55762172617-15-9
YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.
  • $30
In Stock
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Prexasertib
T43101234015-52-1
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
  • $48
In Stock
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