Search Result

Search Results for " pgd2 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T4624	PGD2-IN-1	PGD2-inhibitor	Prostaglandin Receptor
	PGD2-IN-1 (PGD2-inhibitor) is an effective DP receptor antagonist (IC50:0.3 nM), a compound that can inhibit prostaglandin D2 (PGD2) signaling. PGD2-IN-1 specifically targets and regulates the activity of PGD2 receptors ...		Prostaglandin Receptor
T17232	Vidupiprant	AMG 853	Prostaglandin Receptor
	Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.		Prostaglandin Receptor
T1804	HPGDS inhibitor 1	HPGDS-inhibitor-1	PGE Synthase
	HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.		PGE Synthase
T37264	15(R)-15-methyl Prostaglandin D2	15(R)15methyl PGD2	GPR
	15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) is a synthetic analogue of PGD2 and a selective and potent CRTH2/DP2 receptor agonist that modulates eosinophil CD11b expression, actin polymerisation and chemotaxis.		GPR
T16280	Nedocromil	FPL 59002	Leukotriene Receptor , Prostaglandin Receptor , Histamine Receptor
	Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
T3520	Setipiprant	KYTH-105,ACT-129968	GPR , Prostaglandin Receptor
	Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari...		GPR , Prostaglandin Receptor
T15712	Laropiprant	MK-0524	Prostaglandin Receptor
	Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).		Prostaglandin Receptor
T7652	AM211	AM211 free acid	Prostaglandin Receptor
	AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)		Prostaglandin Receptor
T14565	BI-671800	AP-761,Cmpd A	GPR , Prostaglandin Receptor
	BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2...		GPR , Prostaglandin Receptor
T2690	Tranilast	MK 341,SB 252218	RAAS , Prostaglandin Receptor
	Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders.		RAAS , Prostaglandin Receptor
T1866	AT-56		Others , PGE Synthase
	AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.		Others , PGE Synthase
T2396	Ramatroban	BAY u3405	GPR , Prostaglandin Receptor , PPAR
	Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.		GPR , Prostaglandin Receptor , PPAR
T2664	Timapiprant	OC000459	GPR , Prostaglandin Receptor
	Timapiprant (OC000459) is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM).		GPR , Prostaglandin Receptor
T7359	CAY10471 Racemate	TM30089 Racemate	GPR , Prostaglandin Receptor
	CAY10471 Racemate (TM30089 Racemate) is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 Racemate binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and >10,000 nM,respectivel...		GPR , Prostaglandin Receptor
T36153	15(S)-15-methyl Prostaglandin D2	15(S)-15-methyl Prostaglandin D2
	15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 . In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with m...
T36213	16,16-dimethyl Prostaglandin D2	16,16-dimethyl Prostaglandin D2
	16,16-dimethyl PGD2 is a metabolically stable synthetic analog of PGD2. It enhances ADP-induced human platelet aggregation and increases systemic blood pressure in rats.
T36545	Prostaglandin D2 methyl ester	Prostaglandin D2 methyl ester
	Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypoten...
T38257	PGDM
	Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smoot...
T69967	Laropiprant analog
	Laropiprant analog is an antagonist of the prostaglandin PGD2 receptor DP1.
T38389	Prostaglandin D2 Ethanolamide	Prostaglandin D2 Ethanolamide
	Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The ...
T13855	Quinotolast sodium	FR71021	Others
	Quinotolast sodium inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner in the concentration range of 1-100 μg/mL.		Others
T38306	Tetranor-PGDM
	Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD...
T73782	Prostaglandin J2
	Prostaglandin J2 (PGJ2), a derivative of Prostaglandin D2 (PGD2), serves as a potent agonist for PGD2 receptors (DP), exhibiting affinity constants (K i) of 0.9 nM and 6.6 nM for hDP and hCRTH2 receptors, respectively. I...
T15503	HQL-79		Others
	HQL-79 is a selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor. It inhibits the synthesis of PGD2 and acts as an anti-allergic agent (Kd: 0.8 μM and IC50: 6 μM). It also shows no ...		Others
T17099	Timapiprant sodium	OC000459 sodium	Others
	Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from h...		Others
T38113	AL 6598
	Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2α and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a P...
T21869	BW A868C
	BW A868C, a hydantoin compound and structural analogue of BW245C, functions as a selective and potent competitive antagonist of prostaglandin D2 (PGD2), showing no activity on other prostaglandin receptors (IP, EP1, EP2,...
T38365	CAY10597
	The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and...
T41267	PROTAC(H-PGDS)-7
	PROTAC(H-PGDS)-7 is a selective and potent small molecule hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degradation agent that exhibits degradation activity in KU812 cells with a DC50 of 17.3 pM. PROTAC(H-PGDS)-...
T37300	PCTR1	PCTR1
	Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by ...
T37257	13,14-dihydro-15-keto Prostaglandin D1	13,14-dihydro-15-keto Prostaglandin D1
	Prostaglandin D1 (PGD1) is the theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. It is an inhibitor of ADP-induced platelet aggregation in human...
T35811	CAY10410
	CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a pot...
T37275	2,3-dinor-11β-Prostaglandin F2α	2,3-dinor-11β-Prostaglandin F2α
	2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiol...
T37506	MCTR2	MCTR2
	Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is ...
T37507	MCTR3	MCTR3
	Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutat...
T23472	Tranilast Sodium		Others
	Tranilast Sodium has been used for the treatment of bronchial asthma. Tranilast is also used to autoimmune diseases, atopic and fibrotic pat.		Others

Compounds

PGD2-IN-1

T4624

Synonym: PGD2-inhibitor

Target: Prostaglandin Receptor

Vidupiprant

T17232

Synonym: AMG 853

Target: Prostaglandin Receptor

HPGDS inhibitor 1

T1804

Synonym: HPGDS-inhibitor-1

Target: PGE Synthase

15(R)-15-methyl Prostaglandin D2

T37264

Synonym: 15(R)15methyl PGD2

Target: Leukotriene Receptor, Prostaglandin Receptor, Histamine Receptor

Setipiprant

T3520

Synonym: KYTH-105,ACT-129968

Target: GPR, Prostaglandin Receptor

Laropiprant

T15712

Synonym: MK-0524

Target: Prostaglandin Receptor

AM211

T7652

Synonym: AM211 free acid

Target: Prostaglandin Receptor

BI-671800

T14565

Synonym: AP-761,Cmpd A

Target: GPR, Prostaglandin Receptor

Tranilast

T2690

Synonym: MK 341,SB 252218

Target: RAAS, Prostaglandin Receptor

AT-56

T1866

Synonym:

Target: Others, PGE Synthase

Ramatroban

T2396

Synonym: BAY u3405

Target: GPR, Prostaglandin Receptor, PPAR

Timapiprant

T2664

Synonym: OC000459

Target: GPR, Prostaglandin Receptor

CAY10471 Racemate

T7359

Synonym: TM30089 Racemate

Target: GPR, Prostaglandin Receptor

15(S)-15-methyl Prostaglandin D2

T36153

Synonym: 15(S)-15-methyl Prostaglandin D2

Target:

16,16-dimethyl Prostaglandin D2

T36213

Synonym: 16,16-dimethyl Prostaglandin D2

Target:

Prostaglandin D2 methyl ester

T36545

Synonym: Prostaglandin D2 methyl ester

Prostaglandin D2 Ethanolamide

T38389

Synonym: Prostaglandin D2 Ethanolamide

Synonym: OC000459 sodium

13,14-dihydro-15-keto Prostaglandin D1

T37257

Synonym: 13,14-dihydro-15-keto Prostaglandin D1

2,3-dinor-11β-Prostaglandin F2α

T37275

Synonym: 2,3-dinor-11β-Prostaglandin F2α

Cat No.	Product Name	Synonyms	Targets
T13831	Prostaglandin D2	PGD2	Endogenous Metabolite
	Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals,and is a potent endogenous sleep promoting substances.		Endogenous Metabolite

Natural Products

Prostaglandin D2

T13831

Synonym: PGD2

Target: Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04077	HPGDS/PGD2 Protein, Human, Recombinant (His)	Human	E. coli
	HPGDS/PGD2 Protein, Human, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 24.2 kDa. Accession number: O60760
TMPY-03120	Prostaglandin D2 Synthase Protein, Human, Recombinant (His)	Human	HEK293
	PTGDS, also known as L-PGDS, belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic mole...
TMPY-04624	Prostaglandin D2 Synthase Protein, Mouse, Recombinant (His)	Mouse	HEK293
	PTGDS, also known as L-PGDS, belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic mole...
TMPH-02125	SLCO2B1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
TMPJ-00690	PGDS Protein, Human, Recombinant	Human	E. coli
	Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macroph...
TMPJ-00962	AKR1C3 Protein, Human, Recombinant (His)	Human	Human Cells
	AKR1C3, is an enzyme which belongs to the aldo/keto reductase family. It is expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate...
TMPY-05069	Prostaglandin D2 Synthase Protein, Rat, Recombinant (His)	Rat	HEK293
	PTGDS, also known as L-PGDS, belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic mole...