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Search Results for " nr1h4 "

Targets

16

Compounds

6

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T12251 NR1H4 activator 1 Others
NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR).
T2015 Fexaramine FXR , Autophagy
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
T7886 Nidufexor FXR , Autophagy
Nidufexor is an agonist for the farnesoid X receptor (FXR).
T2233 GW 4064 FXR , Autophagy
GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
T15806 LY2562175 FXR , Autophagy
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
T6344 Sevelamer hydrochloride Sevelamer HCl FXR , Autophagy
Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
T31587 DY268 DY 268,DY-268 FXR
DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 = 7.5 nM).
T4379 Tropifexor LJN452 FXR , Autophagy
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
T7436 Cilofexor FXR , Autophagy
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
T11428 Glyco-Obeticholic acid FXR
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
T8471 Vonafexor EYP001,PLX007,pxl007 FXR , HBV
Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
TQ0252 BAR502 FXR , GPCR19 , Autophagy
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
T1789 Obeticholic Acid INT-747,6-Ethylchenodeoxycholic acid,6-ECDCA FXR , Autophagy
Obeticholic Acid (6-ECDCA) is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
T2601 Vidofludimus SC12267,4sc-101 Dehydrogenase , DNA/RNA Synthesis , Interleukin
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
T6053 Turofexorate Isopropyl XL335,FXR-450,WAY-362450 FXR , Autophagy
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
T6690 T0901317 Apoptosis , FXR , Liver X Receptor , ROR
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
Cat No. Product Name Synonyms Targets
T13092 Tauro-Obeticholic acid FXR
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
T0847 Chenodeoxycholic acid CDCA,Chenodiol Potassium Channel , FXR , Endogenous Metabolite , Autophagy
Chenodeoxycholic acid (CDCA) is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as ...
T5574 Guggulsterone Guggulsterone E&Z Apoptosis , FXR , Akt , Caspase , JNK , Autophagy
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T2939 Forskolin Coleonol,Colforsin FXR , Adenylyl cyclase , AChR , Autophagy
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the...
T0700 Ursodeoxycholic acid UDCA,Ursodiol Potassium Channel , Endogenous Metabolite
Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption.
T29078 Ursodeoxycholic acid sodium UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium FXR , Endogenous Metabolite , GPCR19
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting it...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-06768 NR1H4 Protein, Human, Recombinant (His) Human E. coli
TMPY-06756 NR1H4 Protein, Mouse, Recombinant (His) Mouse E. coli
TargetMol