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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12251 | NR1H4 activator 1 | Others | |
NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR). | |||
T2015 | Fexaramine | FXR , Autophagy | |
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds. | |||
T7886 | Nidufexor | FXR , Autophagy | |
Nidufexor is an agonist for the farnesoid X receptor (FXR). | |||
T2233 | GW 4064 | FXR , Autophagy | |
GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM). | |||
T15806 | LY2562175 | FXR , Autophagy | |
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM). | |||
T6344 | Sevelamer hydrochloride | Sevelamer HCl | FXR , Autophagy |
Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption. | |||
T31587 | DY268 | DY 268,DY-268 | FXR |
DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 = 7.5 nM). | |||
T4379 | Tropifexor | LJN452 | FXR , Autophagy |
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM. | |||
T7436 | Cilofexor | FXR , Autophagy | |
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist. | |||
T11428 | Glyco-Obeticholic acid | FXR | |
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR). | |||
T8471 | Vonafexor | EYP001,PLX007,pxl007 | FXR , HBV |
Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects | |||
TQ0252 | BAR502 | FXR , GPCR19 , Autophagy | |
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM). | |||
T1789 | Obeticholic Acid | INT-747,6-Ethylchenodeoxycholic acid,6-ECDCA | FXR , Autophagy |
Obeticholic Acid (6-ECDCA) is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist. | |||
T2601 | Vidofludimus | SC12267,4sc-101 | Dehydrogenase , DNA/RNA Synthesis , Interleukin |
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH). | |||
T6053 | Turofexorate Isopropyl | XL335,FXR-450,WAY-362450 | FXR , Autophagy |
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM | |||
T6690 | T0901317 | Apoptosis , FXR , Liver X Receptor , ROR | |
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13092 | Tauro-Obeticholic acid | FXR | |
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR). | |||
T0847 | Chenodeoxycholic acid | CDCA,Chenodiol | Potassium Channel , FXR , Endogenous Metabolite , Autophagy |
Chenodeoxycholic acid (CDCA) is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as ... | |||
T5574 | Guggulsterone | Guggulsterone E&Z | Apoptosis , FXR , Akt , Caspase , JNK , Autophagy |
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen. | |||
T2939 | Forskolin | Coleonol,Colforsin | FXR , Adenylyl cyclase , AChR , Autophagy |
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the... | |||
T0700 | Ursodeoxycholic acid | UDCA,Ursodiol | Potassium Channel , Endogenous Metabolite |
Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption. | |||
T29078 | Ursodeoxycholic acid sodium | UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium | FXR , Endogenous Metabolite , GPCR19 |
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting it... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-06768 | NR1H4 Protein, Human, Recombinant (His) | Human | E. coli |
TMPY-06756 | NR1H4 Protein, Mouse, Recombinant (His) | Mouse | E. coli |