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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9400 | KCNQ2/3 activator-1 | Others | |
KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator. | |||
T15545 | ICA-27243 | Potassium Channel | |
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects. | |||
T3959 | ICA-069673 | ICA069673 | Potassium Channel |
ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM). | |||
T7612 | ICA 110381 | Potassium Channel | |
ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy | |||
T8446 | QO-40 | Potassium Channel | |
QO-40 is a KCNQ2/3 potassium channels activator. | |||
T28544 | RL648_81 | Potassium Channel | |
RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders. | |||
T78570 | XE991 | Potassium Channel | |
XE991 is a novel and selective Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channels, and M-current, and can be used for the study of neurological disease... | |||
T17262 | XE 991 dihydrochloride | Others , Potassium Channel | |
XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current (IC50s: 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, r... | |||
T4030 | ML213 | CID-3111211 | Potassium Channel |
ML213 (CID-3111211) is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. | |||
T29236 | ZTZ240 | ZTZ 240,ZTZ-240 | |
ZTZ240, a KCNQ2 K+ channel activator, offers a new target to treat hyperexcitability disorders. | |||
T61086 | HN37 | ||
HN37 as a potent and chemically stable antiepileptic drug candidate, with an EC 50 of 37 nM for KCNQ2 [1]. | |||
T69514 | CLE-030 | ||
CLE-030 is a KCNQ2 agonist. CLE030 stably binds to the central cavity. Functional analysis, molecular dynamics simulations, and calculations of the potential of mean force revealed that the carbonyl oxygen of CLE030 inf... | |||
T70786 | ML252 | ||
ML252 is a selective potassium channel inhibitor, specifically targeting the KCNQ2 channel (Kv7.2) with an IC50 value of 69 nM. Additionally, ML252 demonstrates inhibitory activity against Cytochrome P450 isoforms, inclu... |