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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T25376 | Ensifentrine | Ensifentrina,Ensifentrinum | PDE |
Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and... | |||
T9124 | Laninamivir octanoate | CS-8958 | Influenza Virus |
Laninamivir octanoate (CS-8958) is a long acting influenza neuraminidase (NA) inhibitor which shows superior anti-influenza virus activity. | |||
T5159 | Olodaterol hydrochloride | BI-1744 HCl,BI 1744 hydrochloride | Adrenergic Receptor |
Olodaterol hydrochloride (BI-1744 HCl) is a novel, long-acting β2-adrenergic agonist (EC50s: 97.7 nM for the human β2-adrenoceptor) that exerts its pharmacological effect by binding and activating β2-adrenergic receptors... | |||
T3457 | Olodaterol | BI1744,Striverdi Respimat | Adrenergic Receptor |
Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. | |||
T5121 | TD139 | Galectin | |
TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM). | |||
T9826 | GDC-0214 | JAK | |
GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno). | |||
T8900 | Seralutinib | GB002 | PDGFR |
Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension. | |||
T14377 | AZD5423 | Glucocorticoid Receptor | |
AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in subjects with mild allergic asthma. | |||
T0357 | Potassium iodide | Tyrosinase | |
Potassium iodide is used as the treatment of overactive thyroid and as protection of the thyroid gland from the influences of radiation from swallowed or inhaled radioactive iodine. It may be used after accidental exposu... | |||
T72918 | JNJ-49095397 | RV568 | |
JNJ-49095397 (RV568), an inhaled narrow-spectrum kinase inhibitor (NSKI), targets the α and γ isoforms of p38 MAPK and the SRC kinase family, particularly haematopoietic kinase (HCK). Demonstrating potent anti-inflammato... | |||
T35319 | Zy 15109 | N-Acetyl-aspartyl magnesium glutamate,Zy15109,Magnesium N-acetyl-aspartylglutamate | |
Zy 15109 can be used as inhaled mast cell stabilizer. | |||
T39684 | AZD8154 | AZD8154 | |
AZD8154 is a newly developed inhaled compound that selectively inhibits dual PI3Kγδ, aimed at treating airway inflammatory diseases. | |||
T30264 | Navafenterol | AZD8871,LAS-191351,AZD 8871,LAS191351,AZD-8871,LAS 191351 | |
AZD-8871 can present a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an inhaled corticosteroid [ICS]). | |||
T25136 | Aztreonam lysine | Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate | |
Aztreonam lysine is an inhaled anti-pseudomonal treatment for people who have pulmonary Pseudomonas aeruginosa infection with cystic fibrosis (CF). | |||
T70402 | LAS195319 | ||
LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases. | |||
T68272 | Batefenterol Succinate | ||
Batefenterol Succinate is a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties. | |||
T29518 | Abediterol | LAS100977,LAS 100977,LAS-100977 | |
Abediterol (LAS100977) is a new potent, long-acting inhaled beta (2) -adrenergic receptor agonist being developed for the treatment of asthma and chronic obstructive pulmonary disease. | |||
T16439 | PC786 | Others | |
PC786 shows effective antiviral activity against RSV-A (IC50 <0.09 to 0.71 nM) and RSV-B (IC50, 1.3 to 50.6 nM). PC786 is an inhaled respiratory syncytial virus L protein polymerase inhibitor. | |||
T67962 | Sulukast | ||
Sulukast is a potent inhaled leukotriene antagonist, which was found to be effective in preventing both leukotriene_x0002_and antigen-induced bronchospasm in guinea-pigs. | |||
T16477 | PF-03715455 | p38 MAPK | |
PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respectiv... |