Home Tools
Log in
Cart

Search Result

Search Results for " hydroxylase "

Targets

151

Compounds

34

Natural Products

21

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T10861 Collagen proline hydroxylase inhibitor-1 Others
Collagen proline hydroxylase inhibitor-1 exhibits antifibroproliferative activity.
T65816 Prolyl-4-hydroxylase Inhibitor 11 Others
Prolyl-4-hydroxylase Inhibitor 11, a novel proline 4-hydroxylase inhibitor, shows protective effects against oxidative stress and Cu(II) toxicity in Chlorella vulgaris.
T10862 Collagen proline hydroxylase inhibitor Others
Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents.
T12547 Prolyl Hydroxylase inhibitor 1 Others
Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).
T78898 Lysyl hydroxylase 2-IN-2 Monoamine Oxidase
Lysyl Hydroxylase 2-IN-2 (compound 13) is a potent inhibitor of Lysyl Hydroxylase 2 (LH2), exhibiting an IC50 of approximately 500 nM. It effectively inhibits cell migration in 344SQ WT cells without affecting the migrat...
T78889 Lysyl hydroxylase 2-IN-1 Monoamine Oxidase
"Lysyl Hydroxylase 2-IN-1 (compound 12) is a selective inhibitor of lysyl hydroxylase 2 (LH2) with an IC50 of approximately 300 nM and demonstrates specificity for LH2 over LH1 and LH3 [1]."
T82731 Cholesterol 24-hydroxylase-IN-2
Cholesterol 24-hydroxylase-IN-2 is a potent inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1), exhibiting an IC50 value of 5.4 nM, and has potential applications in mammalian imaging of this enzyme [1].
T60796 Cholesterol 24-hydroxylase-IN-1
Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) with IC50 of 8.5 nM that can cross blood-brain barrier [1].
T20700 Racemetirosine Others
Racemetirosine is an inhibitor of Tyrosine 3-monooxygenase, and consequently it inhibits the synthesis of catecholamines.
T21506 Telotristat Hydroxylase
Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential antiserotonergic activity.
T64336 Izilendustat HIF/HIF Prolyl-Hydroxylase
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis.
T19654 Guanoclor VATENSOL Others
Guanoclor (VATENSOL) (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes.
T15796 LX-1031 Hydroxylase , LPA Receptor
LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.
T3169 KC7F2 HIF/HIF Prolyl-Hydroxylase , HIF
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T1896 Ro 61-8048 Hydroxylase
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
T22022 Adaptaquin HIF
Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].
T25283 Cytochrome P450 2C9 Cyp2C9,Human cytochrome P450 2C9,Cytochrome P 450 2C9,S-Mephenytoin 4-hydroxylase
Cytochrome P450 2C9 is a cytochrome P-450 subtype that possesses specificity for acidic xenobiotics. It oxidizes a wide range of important clinical drugs under the categories of nonsteroidal anti-inflammatory agents, ant...
T7694 6-fluoro-DL-Tryptophan 5-HT Receptor
6-fluoro-DL-Tryptophan is an inhibitor of serotonin (5-HT) synthesis.
T13383 Zamicastat BIA 5-1058 BCRP , Hydroxylase , P-gp
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).
T2445 FG-2216 YM-311,FG2216,FG 2216 HIF/HIF Prolyl-Hydroxylase
FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction in vivo.
T0244 Tilorone dihydrochloride Influenza Virus , HIF/HIF Prolyl-Hydroxylase , IFNAR
Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.
T5537 IDF-11774 HIF/HIF Prolyl-Hydroxylase , HIF
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
T12675L PT2399 HIF/HIF Prolyl-Hydroxylase , HIF
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50: 6 nM).
T5392 TP0463518 HIF/HIF Prolyl-Hydroxylase
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
T14119 ACT-678689 Compound Example 1.53.4 Hydroxylase
ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
T7880 IOX4 HIF/HIF Prolyl-Hydroxylase
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
T13398 ZINC13466751 HIF
ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 of 2.0 µM).
T7848 PT-2385 HIF/HIF Prolyl-Hydroxylase , HIF
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
T4106 MK-8617 MK8617 HIF/HIF Prolyl-Hydroxylase
MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).
T13050 SYP-5 HIF/HIF Prolyl-Hydroxylase , HIF
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
T10142L P-Ethynylphenylalanine hydrochloride 4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base) Hydroxylase
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selectively and reversibly the b...
T2488 BAY 87-2243 Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T11897 Telotristat ethyl LX1606 Hydroxylase
Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
T15219 Enarodustat JTZ-951 Others , HIF/HIF Prolyl-Hydroxylase
Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
T21653 1,4-DPCA HIF/HIF Prolyl-Hydroxylase
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).
T7802 M1001 HIF/HIF Prolyl-Hydroxylase , HIF
M1001 is a HIF-2α agonist.
T29797 AKB-6899 AKB6899 VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in...
T11561 HIF-2α-IN-2 HIF/HIF Prolyl-Hydroxylase , HIF
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
T21806 HNHA HDAC
HNHA is an inhibitor of HDAC.
T1823 IOX2 IOX 2,JICL38 HIF/HIF Prolyl-Hydroxylase
IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).
T6604 Nepicastat hydrochloride Nepicastat HCl,RS-25560-197 hydrochloride,SYN-117 hydrochloride,Nepicastat (SYN-117) HCl Hydroxylase
Nepicastat hydrochloride (RS-25560-197 hydrochloride) is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively.The affinity of Nepicasta...
T9627 PHD-1-IN-1 HIF/HIF Prolyl-Hydroxylase
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
T6961 PX-478 PX-478 2HCl HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1α (HIF-1α).
T3180 JNJ-42041935 HIF-PHD Inhibitor II HIF/HIF Prolyl-Hydroxylase
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
T8937 Soticlestat TAK-935,OV935 P450
Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.
T1613 Hydralazine hydrochloride Hydralazine HCl,Apresoline MAO , HIF/HIF Prolyl-Hydroxylase
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an...
T50099 HIF-2α-IN-4 Others , HIF/HIF Prolyl-Hydroxylase
HIF-2a translation inhibitor is a compound used as a molecular building block.
T9890 HIF1-IN-3  Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]- HIF
HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in anticancer studies.
T13289 EHP-101 VCE-​004.8 Cannabinoid Receptor , HIF/HIF Prolyl-Hydroxylase , PPAR
EHP-101 (VCE-004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents diet-induced obesity.
T16679 Belzutifan PT2977,MK-6482 HIF
Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor,...

Compounds

Collagen proline hydroxylase inhibitor-1
T10861
Synonym:
Target: Others
Prolyl-4-hydroxylase Inhibitor 11
T65816
Synonym:
Target: Others
Collagen proline hydroxylase inhibitor
T10862
Synonym:
Target: Others
Prolyl Hydroxylase inhibitor 1
T12547
Synonym:
Target: Others
Lysyl hydroxylase 2-IN-2
T78898
Synonym:
Target: Monoamine Oxidase
Lysyl hydroxylase 2-IN-1
T78889
Synonym:
Target: Monoamine Oxidase
Cholesterol 24-hydroxylase-IN-2
T82731
Synonym:
Target:
Cholesterol 24-hydroxylase-IN-1
T60796
Synonym:
Target:
Racemetirosine
T20700
Synonym:
Target: Others
Telotristat
T21506
Synonym:
Target: Hydroxylase
Izilendustat
T64336
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
Guanoclor
T19654
Synonym: VATENSOL
Target: Others
LX-1031
T15796
Synonym:
Target: Hydroxylase, LPA Receptor
KC7F2
T3169
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
Ro 61-8048
T1896
Synonym:
Target: Hydroxylase
Adaptaquin
T22022
Synonym:
Target: HIF
Cytochrome P450 2C9
T25283
Synonym: Cyp2C9,Human cytochrome P450 2C9,Cytochrome P 450 2C9,S-Mephenytoin 4-hydroxylase
Target:
6-fluoro-DL-Tryptophan
T7694
Synonym:
Target: 5-HT Receptor
Zamicastat
T13383
Synonym: BIA 5-1058
Target: BCRP, Hydroxylase, P-gp
FG-2216
T2445
Synonym: YM-311,FG2216,FG 2216
Target: HIF/HIF Prolyl-Hydroxylase
Tilorone dihydrochloride
T0244
Synonym:
Target: Influenza Virus, HIF/HIF Prolyl-Hydroxylase, IFNAR
IDF-11774
T5537
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
PT2399
T12675L
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
TP0463518
T5392
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
ACT-678689
T14119
Synonym: Compound Example 1.53.4
Target: Hydroxylase
IOX4
T7880
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
ZINC13466751
T13398
Synonym:
Target: HIF
PT-2385
T7848
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
MK-8617
T4106
Synonym: MK8617
Target: HIF/HIF Prolyl-Hydroxylase
SYP-5
T13050
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
p-Ethynylphenylalanine hydrochloride
T10142L
Synonym: 4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base)
Target: Hydroxylase
BAY 87-2243
T2488
Synonym:
Target: Ferroptosis, HIF/HIF Prolyl-Hydroxylase, HIF
Telotristat ethyl
T11897
Synonym: LX1606
Target: Hydroxylase
Enarodustat
T15219
Synonym: JTZ-951
Target: Others, HIF/HIF Prolyl-Hydroxylase
1,4-DPCA
T21653
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
M1001
T7802
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
AKB-6899
T29797
Synonym: AKB6899
Target: VEGFR, HIF/HIF Prolyl-Hydroxylase, HIF
HIF-2α-IN-2
T11561
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
HNHA
T21806
Synonym:
Target: HDAC
IOX2
T1823
Synonym: IOX 2,JICL38
Target: HIF/HIF Prolyl-Hydroxylase
Nepicastat hydrochloride
T6604
Synonym: Nepicastat HCl,RS-25560-197 hydrochloride,SYN-117 hydrochloride,Nepicastat (SYN-117) HCl
Target: Hydroxylase
PHD-1-IN-1
T9627
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
PX-478
T6961
Synonym: PX-478 2HCl
Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy
JNJ-42041935
T3180
Synonym: HIF-PHD Inhibitor II
Target: HIF/HIF Prolyl-Hydroxylase
Soticlestat
T8937
Synonym: TAK-935,OV935
Target: P450
Hydralazine hydrochloride
T1613
Synonym: Hydralazine HCl,Apresoline
Target: MAO, HIF/HIF Prolyl-Hydroxylase
HIF-2α-IN-4
T50099
Synonym:
Target: Others, HIF/HIF Prolyl-Hydroxylase
HIF1-IN-3 
T9890
Synonym: Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-
Target: HIF
EHP-101
T13289
Synonym: VCE-​004.8
Target: Cannabinoid Receptor, HIF/HIF Prolyl-Hydroxylase, PPAR
Belzutifan
T16679
Synonym: PT2977,MK-6482
Target: HIF
1 2 3 4
Cat No. Product Name Synonyms Targets
T6S0071 Fraxinellone HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding...
T5684 Ethyl 3,4-dihydroxybenzoate Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T8153 Glycohyodeoxycholic acid Others , Endogenous Metabolite
glycohyodeoxycholic acid is a major metabolite of the secondary bile acid hyodeoxycholic acid in humans.
T5786 TETRAHYDROPIPERINE Cosmoperine P450 , TRP/TRPV Channel
Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
T6S0923 Hypericin Hypericine,Cyclosan Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC
1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL...
T5S2347 Deoxyshikonin Arnebin 7 Others , HIF/HIF Prolyl-Hydroxylase , Antibacterial
1. Deoxyshikonin (Arnebin 7) may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphatic microvascular endothelial cells (HMVEC-dLy) ...
TL0001 Dencichine L-Dencichin,ODAP,Dencichin Others , HIF/HIF Prolyl-Hydroxylase
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system. It has renoprotective effec...
T0429 Glucosamine Chitosamine,D-Glucosamine MMP , Others , TNF , NF-κB , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , CFTR , Autophagy
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
T2763 Panaxadiol 20(R)-Panaxadiol Others , HIF/HIF Prolyl-Hydroxylase
Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
T5568 H-Tyr(3-I)-OH 3-Iodo-L-tyrosine Endogenous Metabolite
H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones
T6S1315 Oroxylin A 6-Methoxybaicalein,Baicalein 6-methyl ether Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...
T2792 Glucosamine sulfate D-Glucosamine sulphate,D-Glucosaminesulfate MMP , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Autophagy
Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.
T1152 Albendazole SKF-62979 HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
T2805 Chlorogenic Acid NSC-407296,3-O-Caffeoylquinic acid,Heriguard Others , Influenza Virus , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Antibacterial
Chlorogenic Acid (NSC-407296) is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats.
T1205 Chloramphenicol Chlornitromycin,Levomycetin,Chloromycetin ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
T14001 11-Beta-hydroxyandrostenedione NSC-17102,4-Androsten-11β-ol-3,17-dione Endogenous Metabolite
11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozyme...
T11589 Hydroxycitric acid tripotassium hydrate Potassium citrate monohydrate ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tr...
T2941 Glucosamine hydrochloride Chitosamine hydrochloride,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Autophagy
Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
T0256 Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways...
T5S1569 AKBA 3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite
1. AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM.
T7117 Sapropterin dihydrochloride Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,6R-BH4 dihydrochloride Hydroxylase
Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
T10146 4-Hydroxyderricin Dehydrogenase , MAO
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant acti...
T4711 2,4-Dihydroxypyrimidine-5-carboxylic acid Isoorotic acid,Uracil-5-carboxylic acid Others , Endogenous Metabolite
2,4-Dihydroxypyrimidine-5-carboxylic acid (Isoorotic acid) has been obtained from 5-formyluracil by the action of enzyme, thymine 7-hydroxylase. 2,4-Dihydroxypyrimidine-5-carboxylic acid has been used to synthesize N1-al...
TN2252 Syrosingopine Dopamine Receptor
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.
T2S1778 DL-Goitrin Goitrin Others
DL-Goitrin is a potent antithyroid compound found naturally in crucifers. DL-Goitrin is responsible for the induction of glutathione S-transferases. DL-Goitrin is a moderate inhibitor of purified bovine adrenal dopamine ...
T4781 N-Acetyl-L-phenylalanine N-Ac-Phenylalanine Others , Endogenous Metabolite
N-Acetyl-L-phenylalanine (N-Ac-Phenylalanine) is an essential amino acid produced for medical, feed, and nutritional applications. It appears in large amount in urine of patients with phenylketonuria which is a human gen...
T3763 Fumaric acid Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,Donitic acid,Allomaleic acid Endogenous Metabolite
Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or a...
T3776 Rhapontigenin Protigenin P450 , Antibacterial , Antifungal
Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. R...
T5290 (S)-2-Hydroxy-3-phenylpropanoic acid L-(−)-3-Phenyllactic acid Others , Endogenous Metabolite
(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) is a chiral aromatic compound involved in phenylalanine metabolism. It is likely produced from phenylpyruvate via the action of lactate dehydrogenase. The ...
T25900 Oosponol Lenzitin
Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.
T36915 21-Deoxycortisol
21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital a...
T36472 Tetrahydro-11-deoxy Cortisol
Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cyto...
TN4659 Nimbin COX
Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimbin requires to elicit a 50% inhibition of this steroid hydro...
TN3607 Catalpalactone cAMP
Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone c...

Natural Products

Fraxinellone
T6S0071
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, STAT, PD-1/PD-L1
Ethyl 3,4-dihydroxybenzoate
T5684
Synonym:
Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy
glycohyodeoxycholic acid
T8153
Synonym:
Target: Others, Endogenous Metabolite
TETRAHYDROPIPERINE
T5786
Synonym: Cosmoperine
Target: P450, TRP/TRPV Channel
Hypericin
T6S0923
Synonym: Hypericine,Cyclosan
Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC
Deoxyshikonin
T5S2347
Synonym: Arnebin 7
Target: Others, HIF/HIF Prolyl-Hydroxylase, Antibacterial
dencichine
TL0001
Synonym: L-Dencichin,ODAP,Dencichin
Target: Others, HIF/HIF Prolyl-Hydroxylase
Glucosamine
T0429
Synonym: Chitosamine,D-Glucosamine
Target: MMP, Others, TNF, NF-κB, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, CFTR, Autophagy
Panaxadiol
T2763
Synonym: 20(R)-Panaxadiol
Target: Others, HIF/HIF Prolyl-Hydroxylase
H-Tyr(3-I)-OH
T5568
Synonym: 3-Iodo-L-tyrosine
Target: Endogenous Metabolite
Oroxylin A
T6S1315
Synonym: 6-Methoxybaicalein,Baicalein 6-methyl ether
Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy
Glucosamine sulfate
T2792
Synonym: D-Glucosamine sulphate,D-Glucosaminesulfate
Target: MMP, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy
Albendazole
T1152
Synonym: SKF-62979
Target: HIF/HIF Prolyl-Hydroxylase, Microtubule Associated, Antibiotic, Parasite
Chlorogenic Acid
T2805
Synonym: NSC-407296,3-O-Caffeoylquinic acid,Heriguard
Target: Others, Influenza Virus, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Antibacterial
Chloramphenicol
T1205
Synonym: Chlornitromycin,Levomycetin,Chloromycetin
Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic
11-Beta-hydroxyandrostenedione
T14001
Synonym: NSC-17102,4-Androsten-11β-ol-3,17-dione
Target: Endogenous Metabolite
Hydroxycitric acid tripotassium hydrate
T11589
Synonym: Potassium citrate monohydrate
Target: ATP Citrate Lyase, HIF/HIF Prolyl-Hydroxylase, HIF
Glucosamine hydrochloride
T2941
Synonym: Chitosamine hydrochloride,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride
Target: Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy
Citric acid trilithium salt tetrahydrate
T0256
Synonym: Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate
Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR
AKBA
T5S1569
Synonym: 3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid
Target: Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite
Sapropterin dihydrochloride
T7117
Synonym: Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,6R-BH4 dihydrochloride
Target: Hydroxylase
4-Hydroxyderricin
T10146
Synonym:
Target: Dehydrogenase, MAO
2,4-Dihydroxypyrimidine-5-carboxylic acid
T4711
Synonym: Isoorotic acid,Uracil-5-carboxylic acid
Target: Others, Endogenous Metabolite
Syrosingopine
TN2252
Synonym:
Target: Dopamine Receptor
DL-Goitrin
T2S1778
Synonym: Goitrin
Target: Others
N-Acetyl-L-phenylalanine
T4781
Synonym: N-Ac-Phenylalanine
Target: Others, Endogenous Metabolite
Fumaric acid
T3763
Synonym: Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,Donitic acid,Allomaleic acid
Target: Endogenous Metabolite
Rhapontigenin
T3776
Synonym: Protigenin
Target: P450, Antibacterial, Antifungal
(S)-2-Hydroxy-3-phenylpropanoic acid
T5290
Synonym: L-(−)-3-Phenyllactic acid
Target: Others, Endogenous Metabolite
Oosponol
T25900
Synonym: Lenzitin
Target:
21-Deoxycortisol
T36915
Synonym:
Target:
Tetrahydro-11-deoxy Cortisol
T36472
Synonym:
Target:
Nimbin
TN4659
Synonym:
Target: COX
Catalpalactone
TN3607
Synonym:
Target: cAMP

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02587 Tyrosine Hydroxylase Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
Tyrosine hydroxylase (TH) is a rate-limiting enzyme in catecholamine synthesis. Tyrosine hydroxylase activity is modulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathw...
TMPY-02401 Tyrosine Hydroxylase Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Tyrosine hydroxylase (TH) is a rate-limiting enzyme in catecholamine synthesis. Tyrosine hydroxylase activity is modulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathw...
TMPY-03852 Dopamine beta-Hydroxylase Protein, Human, Recombinant (His) Human HEK293
DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH conta...
TMPY-01959 Tryptophan Hydroxylase 1/TPH-1 Protein, Human, Recombinant (His) Human E. coli
Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme that belongs to the biopterin-dependent aromatic amino acid hydroxylase family. TPH1 cont...
TMPY-02707 PAH Protein, Human, Recombinant (415 Asn/Asp, His) Human Baculovirus-Insect Cells
PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding si...
TMPY-01012 P4HB Protein, Human, Recombinant (His) Human HEK293
Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil...
TMPK-00945 ASPH Protein, Human, Recombinant (His) Human E. coli
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se...
TMPK-01083 ASPH Protein, Mouse, Recombinant (His) Mouse E. coli
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se...
TMPH-02958 Tryptophan Hydroxylase 1 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
TMPY-01795 P4HB Protein, Mouse, Recombinant (His) Mouse HEK293
Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil...
TMPH-00563 3-demethoxyubiquinol 3-hydroxylase Protein, E. coli, Recombinant (His) E. coli E. coli
A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstrea...
TMPY-03109 PHYH Protein, Human, Recombinant Human E. coli
PHYH belongs to the family of iron(II)-dependent oxygenases, which typically incorporate one atom of dioxygen into the substrate and one atom into the succinate carboxylate group. PHYH is expressed in liver, kidney, and ...
TMPY-03756 BBOX1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
BBOX1, also known as gamma-BBH, belongs to thegamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last ste...
TMPJ-01043 PHS Protein, Human, Recombinant (His) Human E. coli
Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterin...
TMPY-01380 Cyclophilin B Protein, Human, Recombinant (His) Human HEK293
PPIB is identified as a candidate gene for OI-IX. Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue typically caused by defects in either COL1A1 or COL1A2. A number of other genes causative of th...
TMPH-02075 Semaphorin-3B/SEMA3B Protein, Human, Recombinant (His & Myc) Human Baculovirus
Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providin...
TMPY-03227 CISD1 Protein, Human, Recombinant (His) Human E. coli
Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), the loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioe...
TMPH-01927 PSMB2 Protein, Human, Recombinant (GST) Human E. coli
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen sy...
TMPH-00411 BoNT/C Protein, Clostridium botulinum, Recombinant (His & SUMO) Clostridium botulinum C phage E. coli
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May the...
TMPY-02987 Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal...
TMPY-02706 Vitamin D Receptor/VDR Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal...
Tyrosine Hydroxylase Protein, Mouse, Recombinant (His)
TMPY-02587
Species: Mouse
Expression System: Baculovirus-Insect Cells
Tyrosine Hydroxylase Protein, Human, Recombinant (His)
TMPY-02401
Species: Human
Expression System: Baculovirus-Insect Cells
Dopamine beta-Hydroxylase Protein, Human, Recombinant (His)
TMPY-03852
Species: Human
Expression System: HEK293
Tryptophan Hydroxylase 1/TPH-1 Protein, Human, Recombinant (His)
TMPY-01959
Species: Human
Expression System: E. coli
PAH Protein, Human, Recombinant (415 Asn/Asp, His)
TMPY-02707
Species: Human
Expression System: Baculovirus-Insect Cells
P4HB Protein, Human, Recombinant (His)
TMPY-01012
Species: Human
Expression System: HEK293
ASPH Protein, Human, Recombinant (His)
TMPK-00945
Species: Human
Expression System: E. coli
ASPH Protein, Mouse, Recombinant (His)
TMPK-01083
Species: Mouse
Expression System: E. coli
Tryptophan Hydroxylase 1 Protein, Mouse, Recombinant (His & SUMO)
TMPH-02958
Species: Mouse
Expression System: E. coli
P4HB Protein, Mouse, Recombinant (His)
TMPY-01795
Species: Mouse
Expression System: HEK293
3-demethoxyubiquinol 3-hydroxylase Protein, E. coli, Recombinant (His)
TMPH-00563
Species: E. coli
Expression System: E. coli
PHYH Protein, Human, Recombinant
TMPY-03109
Species: Human
Expression System: E. coli
BBOX1 Protein, Human, Recombinant (His & GST)
TMPY-03756
Species: Human
Expression System: Baculovirus-Insect Cells
PHS Protein, Human, Recombinant (His)
TMPJ-01043
Species: Human
Expression System: E. coli
Cyclophilin B Protein, Human, Recombinant (His)
TMPY-01380
Species: Human
Expression System: HEK293
Semaphorin-3B/SEMA3B Protein, Human, Recombinant (His & Myc)
TMPH-02075
Species: Human
Expression System: Baculovirus
CISD1 Protein, Human, Recombinant (His)
TMPY-03227
Species: Human
Expression System: E. coli
PSMB2 Protein, Human, Recombinant (GST)
TMPH-01927
Species: Human
Expression System: E. coli
BoNT/C Protein, Clostridium botulinum, Recombinant (His & SUMO)
TMPH-00411
Species: Clostridium botulinum C phage
Expression System: E. coli
Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His)
TMPY-02987
Species: Mouse
Expression System: Baculovirus-Insect Cells
Vitamin D Receptor/VDR Protein, Human, Recombinant (His)
TMPY-02706
Species: Human
Expression System: Baculovirus-Insect Cells
Cat No. Product Name
L8500 HIF-1 Signaling Pathway Compound Library

1352 compounds
A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies;
TargetMol