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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10861 | Collagen proline hydroxylase inhibitor-1 | Others | |
Collagen proline hydroxylase inhibitor-1 exhibits antifibroproliferative activity. | |||
T65816 | Prolyl-4-hydroxylase Inhibitor 11 | Others | |
Prolyl-4-hydroxylase Inhibitor 11, a novel proline 4-hydroxylase inhibitor, shows protective effects against oxidative stress and Cu(II) toxicity in Chlorella vulgaris. | |||
T10862 | Collagen proline hydroxylase inhibitor | Others | |
Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents. | |||
T12547 | Prolyl Hydroxylase inhibitor 1 | Others | |
Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM). | |||
T78898 | Lysyl hydroxylase 2-IN-2 | Monoamine Oxidase | |
Lysyl Hydroxylase 2-IN-2 (compound 13) is a potent inhibitor of Lysyl Hydroxylase 2 (LH2), exhibiting an IC50 of approximately 500 nM. It effectively inhibits cell migration in 344SQ WT cells without affecting the migrat... | |||
T78889 | Lysyl hydroxylase 2-IN-1 | Monoamine Oxidase | |
"Lysyl Hydroxylase 2-IN-1 (compound 12) is a selective inhibitor of lysyl hydroxylase 2 (LH2) with an IC50 of approximately 300 nM and demonstrates specificity for LH2 over LH1 and LH3 [1]." | |||
T82731 | Cholesterol 24-hydroxylase-IN-2 | ||
Cholesterol 24-hydroxylase-IN-2 is a potent inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1), exhibiting an IC50 value of 5.4 nM, and has potential applications in mammalian imaging of this enzyme [1]. | |||
T60796 | Cholesterol 24-hydroxylase-IN-1 | ||
Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) with IC50 of 8.5 nM that can cross blood-brain barrier [1]. | |||
T20700 | Racemetirosine | Others | |
Racemetirosine is an inhibitor of Tyrosine 3-monooxygenase, and consequently it inhibits the synthesis of catecholamines. | |||
T21506 | Telotristat | Hydroxylase | |
Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential antiserotonergic activity. | |||
T64336 | Izilendustat | HIF/HIF Prolyl-Hydroxylase | |
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis. | |||
T19654 | Guanoclor | VATENSOL | Others |
Guanoclor (VATENSOL) (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes. | |||
T15796 | LX-1031 | Hydroxylase , LPA Receptor | |
LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally. | |||
T3169 | KC7F2 | HIF/HIF Prolyl-Hydroxylase , HIF | |
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity. | |||
T1896 | Ro 61-8048 | Hydroxylase | |
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM. | |||
T22022 | Adaptaquin | HIF | |
Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2]. | |||
T25283 | Cytochrome P450 2C9 | Cyp2C9,Human cytochrome P450 2C9,Cytochrome P 450 2C9,S-Mephenytoin 4-hydroxylase | |
Cytochrome P450 2C9 is a cytochrome P-450 subtype that possesses specificity for acidic xenobiotics. It oxidizes a wide range of important clinical drugs under the categories of nonsteroidal anti-inflammatory agents, ant... | |||
T7694 | 6-fluoro-DL-Tryptophan | 5-HT Receptor | |
6-fluoro-DL-Tryptophan is an inhibitor of serotonin (5-HT) synthesis. | |||
T13383 | Zamicastat | BIA 5-1058 | BCRP , Hydroxylase , P-gp |
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively). | |||
T2445 | FG-2216 | YM-311,FG2216,FG 2216 | HIF/HIF Prolyl-Hydroxylase |
FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction in vivo. | |||
T0244 | Tilorone dihydrochloride | Influenza Virus , HIF/HIF Prolyl-Hydroxylase , IFNAR | |
Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions. | |||
T5537 | IDF-11774 | HIF/HIF Prolyl-Hydroxylase , HIF | |
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM). | |||
T12675L | PT2399 | HIF/HIF Prolyl-Hydroxylase , HIF | |
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50: 6 nM). | |||
T5392 | TP0463518 | HIF/HIF Prolyl-Hydroxylase | |
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively). | |||
T14119 | ACT-678689 | Compound Example 1.53.4 | Hydroxylase |
ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1]. | |||
T7880 | IOX4 | HIF/HIF Prolyl-Hydroxylase | |
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM) | |||
T13398 | ZINC13466751 | HIF | |
ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 of 2.0 µM). | |||
T7848 | PT-2385 | HIF/HIF Prolyl-Hydroxylase , HIF | |
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM). | |||
T4106 | MK-8617 | MK8617 | HIF/HIF Prolyl-Hydroxylase |
MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM). | |||
T13050 | SYP-5 | HIF/HIF Prolyl-Hydroxylase , HIF | |
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis. | |||
T10142L | P-Ethynylphenylalanine hydrochloride | 4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base) | Hydroxylase |
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selectively and reversibly the b... | |||
T2488 | BAY 87-2243 | Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF | |
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1). | |||
T11897 | Telotristat ethyl | LX1606 | Hydroxylase |
Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production. | |||
T15219 | Enarodustat | JTZ-951 | Others , HIF/HIF Prolyl-Hydroxylase |
Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment. | |||
T21653 | 1,4-DPCA | HIF/HIF Prolyl-Hydroxylase | |
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH). | |||
T7802 | M1001 | HIF/HIF Prolyl-Hydroxylase , HIF | |
M1001 is a HIF-2α agonist. | |||
T29797 | AKB-6899 | AKB6899 | VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF |
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in... | |||
T11561 | HIF-2α-IN-2 | HIF/HIF Prolyl-Hydroxylase , HIF | |
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay). | |||
T21806 | HNHA | HDAC | |
HNHA is an inhibitor of HDAC. | |||
T1823 | IOX2 | IOX 2,JICL38 | HIF/HIF Prolyl-Hydroxylase |
IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM). | |||
T6604 | Nepicastat hydrochloride | Nepicastat HCl,RS-25560-197 hydrochloride,SYN-117 hydrochloride,Nepicastat (SYN-117) HCl | Hydroxylase |
Nepicastat hydrochloride (RS-25560-197 hydrochloride) is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively.The affinity of Nepicasta... | |||
T9627 | PHD-1-IN-1 | HIF/HIF Prolyl-Hydroxylase | |
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM). | |||
T6961 | PX-478 | PX-478 2HCl | HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy |
PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1α (HIF-1α). | |||
T3180 | JNJ-42041935 | HIF-PHD Inhibitor II | HIF/HIF Prolyl-Hydroxylase |
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. | |||
T8937 | Soticlestat | TAK-935,OV935 | P450 |
Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research. | |||
T1613 | Hydralazine hydrochloride | Hydralazine HCl,Apresoline | MAO , HIF/HIF Prolyl-Hydroxylase |
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an... | |||
T50099 | HIF-2α-IN-4 | Others , HIF/HIF Prolyl-Hydroxylase | |
HIF-2a translation inhibitor is a compound used as a molecular building block. | |||
T9890 | HIF1-IN-3 | Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]- | HIF |
HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in anticancer studies. | |||
T13289 | EHP-101 | VCE-004.8 | Cannabinoid Receptor , HIF/HIF Prolyl-Hydroxylase , PPAR |
EHP-101 (VCE-004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents diet-induced obesity. | |||
T16679 | Belzutifan | PT2977,MK-6482 | HIF |
Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor,... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6S0071 | Fraxinellone | HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1 | |
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding... | |||
T5684 | Ethyl 3,4-dihydroxybenzoate | Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy | |
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain. | |||
T8153 | Glycohyodeoxycholic acid | Others , Endogenous Metabolite | |
glycohyodeoxycholic acid is a major metabolite of the secondary bile acid hyodeoxycholic acid in humans. | |||
T5786 | TETRAHYDROPIPERINE | Cosmoperine | P450 , TRP/TRPV Channel |
Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects. | |||
T6S0923 | Hypericin | Hypericine,Cyclosan | Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC |
1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL... | |||
T5S2347 | Deoxyshikonin | Arnebin 7 | Others , HIF/HIF Prolyl-Hydroxylase , Antibacterial |
1. Deoxyshikonin (Arnebin 7) may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphatic microvascular endothelial cells (HMVEC-dLy) ... | |||
TL0001 | Dencichine | L-Dencichin,ODAP,Dencichin | Others , HIF/HIF Prolyl-Hydroxylase |
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system. It has renoprotective effec... | |||
T0429 | Glucosamine | Chitosamine,D-Glucosamine | MMP , Others , TNF , NF-κB , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , CFTR , Autophagy |
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis. | |||
T2763 | Panaxadiol | 20(R)-Panaxadiol | Others , HIF/HIF Prolyl-Hydroxylase |
Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng. | |||
T5568 | H-Tyr(3-I)-OH | 3-Iodo-L-tyrosine | Endogenous Metabolite |
H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones | |||
T6S1315 | Oroxylin A | 6-Methoxybaicalein,Baicalein 6-methyl ether | Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy |
1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v... | |||
T2792 | Glucosamine sulfate | D-Glucosamine sulphate,D-Glucosaminesulfate | MMP , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Autophagy |
Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition. | |||
T1152 | Albendazole | SKF-62979 | HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite |
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations. | |||
T2805 | Chlorogenic Acid | NSC-407296,3-O-Caffeoylquinic acid,Heriguard | Others , Influenza Virus , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Antibacterial |
Chlorogenic Acid (NSC-407296) is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. | |||
T1205 | Chloramphenicol | Chlornitromycin,Levomycetin,Chloromycetin | ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic |
Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis. | |||
T14001 | 11-Beta-hydroxyandrostenedione | NSC-17102,4-Androsten-11β-ol-3,17-dione | Endogenous Metabolite |
11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozyme... | |||
T11589 | Hydroxycitric acid tripotassium hydrate | Potassium citrate monohydrate | ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF |
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tr... | |||
T2941 | Glucosamine hydrochloride | Chitosamine hydrochloride,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride | Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Autophagy |
Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. | |||
T0256 | Citric acid trilithium salt tetrahydrate | Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate | Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR |
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways... | |||
T5S1569 | AKBA | 3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid | Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite |
1. AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM. | |||
T7117 | Sapropterin dihydrochloride | Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,6R-BH4 dihydrochloride | Hydroxylase |
Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU. | |||
T10146 | 4-Hydroxyderricin | Dehydrogenase , MAO | |
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant acti... | |||
T4711 | 2,4-Dihydroxypyrimidine-5-carboxylic acid | Isoorotic acid,Uracil-5-carboxylic acid | Others , Endogenous Metabolite |
2,4-Dihydroxypyrimidine-5-carboxylic acid (Isoorotic acid) has been obtained from 5-formyluracil by the action of enzyme, thymine 7-hydroxylase. 2,4-Dihydroxypyrimidine-5-carboxylic acid has been used to synthesize N1-al... | |||
TN2252 | Syrosingopine | Dopamine Receptor | |
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor. | |||
T2S1778 | DL-Goitrin | Goitrin | Others |
DL-Goitrin is a potent antithyroid compound found naturally in crucifers. DL-Goitrin is responsible for the induction of glutathione S-transferases. DL-Goitrin is a moderate inhibitor of purified bovine adrenal dopamine ... | |||
T4781 | N-Acetyl-L-phenylalanine | N-Ac-Phenylalanine | Others , Endogenous Metabolite |
N-Acetyl-L-phenylalanine (N-Ac-Phenylalanine) is an essential amino acid produced for medical, feed, and nutritional applications. It appears in large amount in urine of patients with phenylketonuria which is a human gen... | |||
T3763 | Fumaric acid | Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,Donitic acid,Allomaleic acid | Endogenous Metabolite |
Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or a... | |||
T3776 | Rhapontigenin | Protigenin | P450 , Antibacterial , Antifungal |
Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. R... | |||
T5290 | (S)-2-Hydroxy-3-phenylpropanoic acid | L-(−)-3-Phenyllactic acid | Others , Endogenous Metabolite |
(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) is a chiral aromatic compound involved in phenylalanine metabolism. It is likely produced from phenylpyruvate via the action of lactate dehydrogenase. The ... | |||
T25900 | Oosponol | Lenzitin | |
Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects. | |||
T36915 | 21-Deoxycortisol | ||
21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital a... | |||
T36472 | Tetrahydro-11-deoxy Cortisol | ||
Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cyto... | |||
TN4659 | Nimbin | COX | |
Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimbin requires to elicit a 50% inhibition of this steroid hydro... | |||
TN3607 | Catalpalactone | cAMP | |
Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone c... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02587 | Tyrosine Hydroxylase Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Tyrosine hydroxylase (TH) is a rate-limiting enzyme in catecholamine synthesis. Tyrosine hydroxylase activity is modulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathw... | |||
TMPY-02401 | Tyrosine Hydroxylase Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Tyrosine hydroxylase (TH) is a rate-limiting enzyme in catecholamine synthesis. Tyrosine hydroxylase activity is modulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathw... | |||
TMPY-03852 | Dopamine beta-Hydroxylase Protein, Human, Recombinant (His) | Human | HEK293 |
DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH conta... | |||
TMPY-01959 | Tryptophan Hydroxylase 1/TPH-1 Protein, Human, Recombinant (His) | Human | E. coli |
Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme that belongs to the biopterin-dependent aromatic amino acid hydroxylase family. TPH1 cont... | |||
TMPY-02707 | PAH Protein, Human, Recombinant (415 Asn/Asp, His) | Human | Baculovirus-Insect Cells |
PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding si... | |||
TMPY-01012 | P4HB Protein, Human, Recombinant (His) | Human | HEK293 |
Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil... | |||
TMPK-00945 | ASPH Protein, Human, Recombinant (His) | Human | E. coli |
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se... | |||
TMPK-01083 | ASPH Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se... | |||
TMPH-02958 | Tryptophan Hydroxylase 1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
TMPY-01795 | P4HB Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil... | |||
TMPH-00563 | 3-demethoxyubiquinol 3-hydroxylase Protein, E. coli, Recombinant (His) | E. coli | E. coli |
A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstrea... | |||
TMPY-03109 | PHYH Protein, Human, Recombinant | Human | E. coli |
PHYH belongs to the family of iron(II)-dependent oxygenases, which typically incorporate one atom of dioxygen into the substrate and one atom into the succinate carboxylate group. PHYH is expressed in liver, kidney, and ... | |||
TMPY-03756 | BBOX1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
BBOX1, also known as gamma-BBH, belongs to thegamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last ste... | |||
TMPJ-01043 | PHS Protein, Human, Recombinant (His) | Human | E. coli |
Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterin... | |||
TMPY-01380 | Cyclophilin B Protein, Human, Recombinant (His) | Human | HEK293 |
PPIB is identified as a candidate gene for OI-IX. Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue typically caused by defects in either COL1A1 or COL1A2. A number of other genes causative of th... | |||
TMPH-02075 | Semaphorin-3B/SEMA3B Protein, Human, Recombinant (His & Myc) | Human | Baculovirus |
Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providin... | |||
TMPY-03227 | CISD1 Protein, Human, Recombinant (His) | Human | E. coli |
Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), the loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioe... | |||
TMPH-01927 | PSMB2 Protein, Human, Recombinant (GST) | Human | E. coli |
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen sy... | |||
TMPH-00411 | BoNT/C Protein, Clostridium botulinum, Recombinant (His & SUMO) | Clostridium botulinum C phage | E. coli |
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May the... | |||
TMPY-02987 | Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal... | |||
TMPY-02706 | Vitamin D Receptor/VDR Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal... |
Cat No. | Product Name | ||
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L8500 | HIF-1 Signaling Pathway Compound Library | 1352 compounds | |
A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies; |