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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8730 | BMS986260 | TGF-beta/Smad | |
BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM). | |||
T0125 | Epirubicin hydrochloride | Pharmorubicin,4'-epidoxorubicin HCl,Epirubicin HCl,4'-Epidoxorubicin hydrochloride | Apoptosis , DNA/RNA Synthesis , Topoisomerase |
Epirubicin hydrochloride (Pharmorubicin) is an antineoplastic agent which can inhibit Topoisomerase. | |||
TP1433 | CMD178 TFA | STAT | |
CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling. | |||
T30077 | Anisperimus | LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195 | Caspase |
Anisperimus (LF 15-0195) is an immunosuppressant that enhances activation-induced T-cell death by promoting caspase-8 and caspase-10 activation at the DISC level, and prevents CNS autoimmunity by promoting the developmen... | |||
T2247 | KenPaullone | 9-Bromopaullone,NSC-664704 | GSK-3 , CDK |
KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp... | |||
TN6393 | Fulvotomentoside A | Others | |
Fulvotomentoside A could decrease overexpression of IL-6 and IL-17A, and increase the expression of specific transcription factor Foxp3 of regulatory T cells significantly in intestine. It may be one of the mechanisms th... | |||
T8378 | AS2863619 | CDK , STAT | |
AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively). | |||
T3S1967 | (S)-Indoximod | N-ME-Tryptophan,Abrine,L-Abrine | Others , Indoleamine 2,3-Dioxygenase (IDO) |
(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse L... | |||
T10382 | AS2863619 free base | CDK | |
AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 and CDK19 inhibitor (IC50s: 0.61 nM and 4.28 nM). STAT5 act... | |||
TP1770 | CMD178 | ||
CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway. | |||
T15169 | DS-437 | Others | |
DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3. | |||
T69093 | Epirubicin | IMI-28,4-epi DX,4'-Epidoxorubicin,IMI 28,4-epidoxorubicin,epi DX,4-epiadriamycin | |
Epirubicin (4'-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, serves as an antineoplastic agent primarily by inhibiting Topoisomerase, thereby impeding DNA and RNA synthesis. Additionally, it funct... |