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Search Results for " catechol o-methyltransferase "

15

Compounds

1

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T75389 Catechol O-methyltransferase
Catechol O-methyltransferase (COMT) is a magnesium-dependent enzyme that mediates the transfer of methyl groups from S-adenosyl methionine to the hydroxyl group on dopamine, thus converting it to 3-methoxytyramine. COMT ...
T24030 Entacapone acid AG1290,AG 1290,AG-1290 Transferase
Entacapone acid (AG 1290) is a selective and reversible inhibitor of catechol-O-methyltransferase(COMT).
T16398 Opicapone BIA 9-1067 Transferase
Opicapone (BIA 9-1067) reduces the ATP content of the cells (IC50: 98 μM). Opicapone is an effective third-generation catechol-O-methyltransferase inhibitor for the research of Parkinson's disease and motor fluctuations.
T2216 Entacapone OR-611 Transferase
Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).
T6708 Tolcapone Tasmar,Ro 40-7592 Apoptosis , Beta Amyloid , Transferase
Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.
T27162 DHMPA
DHMPA is an inhibitor of catechol-O-methyltransferase (COMT), it also reduces tissue norepinephrine and blood pressure.
T29029 U-0521
U-0521, an inhibitor of catechol-O-methyltransferase (COMT), enhances the availability and utilization of levodopa in the brain.
T26797 BIA 3-335 BIA-3-335,BIA3335
BIA 3-335, an inhibition of catechol-O-methyltransferase, could have applications for Parkinson's Disease.
T28593 Ro 61-1448 Ro-61-1448,Ro 611448
Ro 61-1448 is a metabolite of tolcapone, a catechol-O-methyltransferase inhibitor.
T36122 3-O-methyl-L-DOPA (hydrate)
3-O-methyl-L-DOPA is a metabolite of L-DOPA , produced by the activity of catechol O-methyltransferase. 3-O-methyl-L-DOPA may have effects of its own or it may compete with the actions of L-DOPA.
T16279 Nebicapone BIA 3-202 Others
Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to ...
T11207 Entacapone sodium salt Others
Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapo...
T70608 Cis-Entacapone
cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone. It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV li...
T26997 CGP-28014
CGP-28014 is an inhibitor of catechol-O-methyltransferase. CGP-28014 increases the renal excretion of both dopamine and dihydroxyphenylacetic acid (DOPAC) but does not affect renal sodium handling indicating a different ...
T36207 Methylspinazarin
Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxyl...
Cat No. Product Name Synonyms Targets
T2209 Serotonin hydrochloride 5-HT hydrochloride,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride 5-HT Receptor , Endogenous Metabolite , Transferase
Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM).

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-05158 COMT Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
TargetMol