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Search Results for " btk "

Targets

171

Compounds

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9706 BTK inhibitor 17 BTK
BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor 17 can be used in rheumatoid arthritis studies.
T10629 Btk inhibitor 2 BGB-3111 analog BTK
Btk inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.
T35330 BTK inhibitor 1 BTK
BTK inhibitor 1 (Compound 27) is a BTK inhibitor (IC50: 0.11 nM) with an inhibitory effect on B-cell activation in hWB with an IC50 of 2 nM.
TQ0230 BTK IN-1 SNS062 analog BTK
BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).
T60542 BTK-IN-16 BTK
BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.
T40185 BTK inhibitor 19
BTK inhibitor 19 is a highly selective, covalent BTK inhibitor ( IC 50 = 2.7 nM).
T39612 BTK-IN-5
BTK-IN-5 is a covalent inhibitor of Bruton's tyrosine kinase (BTK) designed for the treatment of medical conditions including cardiovascular diseases, respiratory diseases, inflammation, and diabetes.
T9813 JAK3/BTK-IN-2 JAK , BTK
JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor. JAK3/ BTk-in-2 inhibits both BTK and JAK3, which are two important targets IN autoimmune diseases. JAK3/ BTk-in-2 simultaneously inhibits the BTK/JAK3 signaling pathway, sho...
T9814 JAK3/BTK-IN-1 JAK , BTK
JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important targets in autoimmune diseases. JAK3/ BTk-in-1 simultaneously inh...
T10628 BTK inhibitor 13 Others
BTK inhibitor 13 (compound 8) is an effective and selective BTK inhibitor(IC50: 1.2 nM).
T36297 Btk inhibitor 1 hydrochloride
Btk inhibitor 1 Hcl is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor.IC50 value:Target: BtkFrom PCT Int. Appl. (2012), WO 2012158843 A2 20121122. [1]. PCT Int. Appl. (2012), WO 2012158843 A2 20121122.
T14956 CHMFL-BTK-01 BTK
CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.
T10627 BTK inhibitor 10 Others
BTK inhibitor 10 is a potent and orally active BTK inhibitor. It has the potential for rheumatoid arthritis treatment.
T62716 BTK-IN-10
BTK-IN-10 is a potent inhibitor of BTK, acting on wild-type BTK (IC50<5 nM) or mutant BTK (C481S) (IC50<5 nM).
T75124 BTK-IN-24
BTK-IN-24 (compound 195) is a potent BTK inhibitor via a ubiquitin proteolytic pathway [1] .
T63810 BTK-IN-7
BTK-IN-7 is a selective and potent BTK inhibitor with an IC50 value of 4.0 nM. BTK-IN-7 exhibits high selectivity at both the enzymatic (ITK>250-fold, EGFR>2500-fold) and cellular levels (ITK>227-fold, EGFR27-fold). BTK-...
T63173 BTK-IN-8
BTK-IN-8 is a potent, selective, peripheral covalent BTK inhibitor with an IC50 value of 0.22 nM and a Kd value of 0.91 nM. BTK-IN-8 exhibits good potency in whole blood CD69 cells with an IC50 value of 0.029 μM.
T73276 BTK-IN-23
BTK-IN-23 is a BTK inhibitor with an IC50 value of 12.8 nM, demonstrating kinase selectivity superior to Ibrutinib [1]. It also effectively inhibits BLX and BMX, with IC50 values of 35.6 nM and 5.7 nM, respectively.
T72664 BTK inhibitor 20
BTK inhibitor 20 is a potent BTK inhibitor with an IC 50 of 8 nM .
T73275 BTK-IN-22
BTK-IN-22, a BTK inhibitor (IC 50: 0.9 nM), also exhibits inhibition against BLX and BMX with IC 50 values of 1.4 and 1.2 nM, respectively. Demonstrating enhanced kinase selectivity, BTK-IN-22 outperforms Ibrutinib in th...
T62472 BTK-IN-6
BTK-IN-6 is a potent inhibitor of Bruton's tyrosine kinase (BTK). BTK-IN-6 has shown research potential in immune diseases, cardiovascular diseases, cancer, viral infections, inflammation, metabolic/endocrine dysfunction...
T73319 BTK-IN-19
BTK-IN-19 is a reversible BTK inhibitor with an IC 50 of <0.001 μM .
T63182 BTK-IN-15
BTK-IN-15 is a novel, orally active Bruton's tyrosine kinase (BTK) inhibitor that inhibits BTK (IC50: 0.7 nM). BTK-IN-15 induces apoptosis in cancer cells and has good kinase selectivity and anti-tumour activity.
T79113 BTK-IN-25 BTK
BTK-IN-25 (compound 71) is a potent BTK inhibitor, demonstrating an IC50 of 0.77 nM against BTK(C481S) and achieving an IC50 of 1 nM in DOHH2 cells [1].
T73303 BTK-IN-17
BTK-IN-17 is a selective, orally active inhibitor of Bruton's Tyrosine Kinase (BTK) with an inhibition concentration (IC50) value of 13.7 nM. It effectively reduces the expression of phosphorylated BTK at Tyrosine 223 (p...
T63254 BTK-IN-11
BTK-IN-11 is a potent inhibitor of BTK. BTK-IN-11 has shown potential for research in diseases related to autoimmune diseases, inflammatory diseases or cancer.
T73318 BTK-IN-18
BTK-IN-18 is a potent, reversible inhibitor of Bruton's tyrosine kinase (BTK) with an inhibitory concentration (IC50) of 0.002 µM. Additionally, it effectively suppresses CD69 and CD86 expression in vivo.
T64042 BTK inhibitor 18
BTK inhibitor 18 is a selective, potent, covalent, orally active Btk inhibitor (IC50: 142 nM) that exhibits anti-inflammatory effects.
T63179 BTK-IN-9
BTK-IN-9 is a reversible inhibitor of BTK that shows strong anti-proliferative effects in condyloma cells.BTK-IN-9 specifically disrupts mitochondrial membrane potential, increases reactive oxygen species levels in Z138 ...
T79812 BTK-IN-27 BTK
BTK-IN-27 (example 8), a potent BTK inhibitor with an IC50 of 0.2 nM, demonstrates anti-proliferative effects in TMD8 cells with an IC50 of less than 5 nM. It is suitable for the research of various conditions including ...
T78782 PROTAC BTK Degrader-6 BTK
PROTAC BTK Degrader-6 (Compound 15), with a DC50 of 3.18 nM, exhibits anti-inflammatory properties by inhibiting NF-κB activation and suppressing the expression of pro-inflammatory cytokines, such as IL-1β and IL-6 [1].
T74636 PROTAC BTK Degrader-1
PROTAC BTK Degrader-1, a powerful, selective, and orally bioavailable degrader of PROTAC BTK, demonstrates effective reduction in BTK protein levels and tumor suppression. It exhibits IC50 values of 34.51 nM for BTK WT a...
T62813 JAK3/BTK-IN-6
JAK3/BTK-IN-6 is a potent dual inhibitor of BTK (IC50: 0.6 nM) and JAK3 (IC50: 0.4 nM).JAK3/BTK-IN-6 exhibits good metabolic stability in human liver microsomes.JAK3/BTK-IN-6 can be used to study blood and immune disease...
T79067 PROTAC BTK Degrader-3 PROTACs
PROTAC BTK Degrader-3 is a potent degrader of Bruton's tyrosine kinase (BTK), exhibiting a DC50 (median degradation concentration) of 10.9 nM in Mino cells. This compound shows promise for research into B-cell malignanci...
T79292 PROTAC BTK Degrader-5 BTK
PROTAC BTK Degraders-5 (Compound 3e) is a selective Bruton's tyrosine kinase (BTK) degrader with a DC50 of 7.0 nM in JeKo-1 cells, demonstrating specificity by not affecting CRBN neosubstrates. It also exhibits antiproli...
T62234 JAK3/BTK-IN-3
JAK3/BTK-IN-3 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway has a synergistic effect and JAK3/BTK-IN-3 has sh...
T62153 JAK3/BTK-IN-5
JAK3/BTK-IN-5 is a potent inhibitor of JAK3/BTK. where BTK and JAK3 are two key targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway has a synergistic effect and JAK3/BTK-IN-5 has po...
T62553 JAK3/BTK-IN-4
JAK3/BTK-IN-4 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signaling pathway has a synergistic effect and JAK3/BTK-IN-4 has pot...
T73868 PROTAC BTK Degrader-2
PROTAC BTK Degrader-2, a potent degrader of BTK through the PROTAC mechanism, effectively diminishes BTK protein levels [1].
T16730 Remibrutinib BTK
Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50: 1 nM). Remibrutinib has the potential for Chronic urticar...
T1976 RN486 BTK
RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).
T5138 BMS-986142 BTK
BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).
T16157 MT-802 BTK , PROTACs
MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).
T36287 Pirtobrutinib BTK
Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to t...
T10625 IBT6A BTK
IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.
T10626 (Rac)-IBT6A Others , BTK
(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.
T2472 CGI-1746 BTK , Autophagy
CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.
TQ0242 Fenebrutinib GDC-0853 BTK
Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).
T5407 Branebrutinib BMS986195 BTK
Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family (IC50 <1 nM for BTK).
T12542 Rilzabrutinib PRN1008 EGFR , Others , HER , BTK
Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).

Compounds

BTK inhibitor 17
T9706
Synonym:
Target: BTK
Btk inhibitor 2
T10629
Synonym: BGB-3111 analog
Target: BTK
BTK inhibitor 1
T35330
Synonym:
Target: BTK
BTK IN-1
TQ0230
Synonym: SNS062 analog
Target: BTK
BTK-IN-16
T60542
Synonym:
Target: BTK
BTK inhibitor 19
T40185
Synonym:
Target:
BTK-IN-5
T39612
Synonym:
Target:
JAK3/BTK-IN-2
T9813
Synonym:
Target: JAK, BTK
JAK3/BTK-IN-1
T9814
Synonym:
Target: JAK, BTK
BTK inhibitor 13
T10628
Synonym:
Target: Others
Btk inhibitor 1 hydrochloride
T36297
Synonym:
Target:
CHMFL-BTK-01
T14956
Synonym:
Target: BTK
BTK inhibitor 10
T10627
Synonym:
Target: Others
BTK-IN-10
T62716
Synonym:
Target:
BTK-IN-24
T75124
Synonym:
Target:
BTK-IN-7
T63810
Synonym:
Target:
BTK-IN-8
T63173
Synonym:
Target:
BTK-IN-23
T73276
Synonym:
Target:
BTK inhibitor 20
T72664
Synonym:
Target:
BTK-IN-22
T73275
Synonym:
Target:
BTK-IN-6
T62472
Synonym:
Target:
BTK-IN-19
T73319
Synonym:
Target:
BTK-IN-15
T63182
Synonym:
Target:
BTK-IN-25
T79113
Synonym:
Target: BTK
BTK-IN-17
T73303
Synonym:
Target:
BTK-IN-11
T63254
Synonym:
Target:
BTK-IN-18
T73318
Synonym:
Target:
BTK inhibitor 18
T64042
Synonym:
Target:
BTK-IN-9
T63179
Synonym:
Target:
BTK-IN-27
T79812
Synonym:
Target: BTK
PROTAC BTK Degrader-6
T78782
Synonym:
Target: BTK
PROTAC BTK Degrader-1
T74636
Synonym:
Target:
JAK3/BTK-IN-6
T62813
Synonym:
Target:
PROTAC BTK Degrader-3
T79067
Synonym:
Target: PROTACs
PROTAC BTK Degrader-5
T79292
Synonym:
Target: BTK
JAK3/BTK-IN-3
T62234
Synonym:
Target:
JAK3/BTK-IN-5
T62153
Synonym:
Target:
JAK3/BTK-IN-4
T62553
Synonym:
Target:
PROTAC BTK Degrader-2
T73868
Synonym:
Target:
Remibrutinib
T16730
Synonym:
Target: BTK
RN486
T1976
Synonym:
Target: BTK
BMS-986142
T5138
Synonym:
Target: BTK
MT-802
T16157
Synonym:
Target: BTK, PROTACs
Pirtobrutinib
T36287
Synonym:
Target: BTK
IBT6A
T10625
Synonym:
Target: BTK
(Rac)-IBT6A
T10626
Synonym:
Target: Others, BTK
CGI-1746
T2472
Synonym:
Target: BTK, Autophagy
Fenebrutinib
TQ0242
Synonym: GDC-0853
Target: BTK
Branebrutinib
T5407
Synonym: BMS986195
Target: BTK
Rilzabrutinib
T12542
Synonym: PRN1008
Target: EGFR, Others, HER, BTK
1 2 3 4

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-02271 BTK Protein, Human, Recombinant (His) Human Baculovirus
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell ...
TMPH-02037 Human rhinovirus 1B (HRV-1B) Genome polyprotein (His & Myc) HRV-1B E. coli
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activatio...
TMPY-05249 ITK Protein, Human, Recombinant (Actived By LCK, GST) Human Baculovirus-Insect Cells
IL-2-inducible T cell kinase is a member of the protein kinase superfamily, Tyr protein kinase family, and TEC subfamily. It contains 1 Btk-type zinc finger, 1 PH domain, 1 protein kinase domain, 1 SH2 domain, and 1 SH3 ...
TMPY-04570 ITK Protein, Mouse, Recombinant (aa 351-619, His & GST) Mouse Baculovirus-Insect Cells
IL-2-inducible T cell kinase is a member of the protein kinase superfamily, Tyr protein kinase family, and TEC subfamily. It contains 1 Btk-type zinc finger, 1 PH domain, 1 protein kinase domain, 1 SH2 domain, and 1 SH3 ...
TMPH-02664 Aldolase C Protein, Mouse, Recombinant (His) Mouse Yeast
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors an...
TargetMol