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Results for "

543

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    53
    TargetMol | Inhibitors_Agonists
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    3
    TargetMol | Peptide_Products
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    1
    TargetMol | Inhibitory_Antibodies
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PF-543
Sphingosine Kinase 1 Inhibitor II, PF 543
T60851415562-82-1
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 of 2.0 nM and Ki of 3.6 nM.
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PF-543 hydrochloride
PF-543 HCL
T88401706522-79-3
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
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TargetMol | Inhibitor Sale
DMP-543
XR-543
T15143160588-45-4
DMP-543 (XR-543) is a KV7 channel blocker that enhances neurotransmitter release.
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6-8 weeks
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TargetMol | Inhibitor Sale
PF-543 Citrate
PF543 Citrate, Sphingosine Kinase 1 Inhibitor II Citrate
T124361415562-83-2
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a selective and potent inhibitor of sphingosine kinase 1 (SPHK1) and is an efficient inhibitor of 1-phosphate sphingosine (S1P) formation. It possesses anticancer, antifibrotic, and anti-inflammatory activities and can be used in research on colorectal cancer.
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7-10 days
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VHF 543, amine
T2050083053860-67-3
VHF 543, Amine is a potent ligand for the WD40 repeat domain (WDR) of DCAF1 (Kd = 31 nM measured by surface plasmon resonance). VHF 543, Amine carries a primary amine functional group handle that allows for rapid binding to linker target protein ligands.
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35 days
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YM-543 trimethylamine
ASP 543,ASP-543,ASP543
T29188918802-70-7
YM-543, a sodium-glucose transporter 2 (SGLT-2) inhibitor, is used potentially for the treatment of type 2 diabetes.
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6-8 weeks
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YM-543 choline
T703901610007-47-0
YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and its inhibition may present a novel therapeutic strategy for treating diabetes. YM543 potently and selectively inhibited mouse and human SGLT2 activities at nanomolar ranges. In vivo single oral administration of YM543 dose-dependently and significantly reduced blood glucose levels and improved glucose tolerance with a concomitant increase in urinary glucose excretion in KK Ay type 2 diabetic mice, effects that were sustained even after 12 h.
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8-10 weeks
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GAD65 (524-543)
T82354152468-44-5
GAD65 (524-543) is a biologically active peptide comprising amino acids 524 to 543 of glutamic acid decarboxylase 65 (GAD65). It represents an early islet antigen fragment that elicits proliferative T cell responses in the non-obese diabetic (NOD) mouse model, instrumental in spontaneous autoimmune diabetes research. The peptide serves as a specific, possibly low-affinity stimulant for the diabetogenic T cell clone BDC2.5. Notably, immunization with GAD65 (524-543) heightens NOD mice's vulnerability to type 1 diabetes when subjected to the adoptive transfer of BDC2.5 T cells.
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Collagen type IV alpha1 (531-543)
Hep III peptide,Gefyfdlrlkgdk
TP2452119953-02-5
Collagen type IV alpha1 (531-543) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of type IV collagen and plays a role in angiogenesis.
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CGS 15435
T1078395853-92-2In house
CGS 15435 is a potent thromboxen (TxA2) synthetase inhibitor (IC50: 1 nM). CGS 15435 acts on PGI2 synthase, cyclooxygenase and liposynthase with much less selectivity than on thromboxin synthase.
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8-10weeks
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TargetMol | Inhibitor Sale
PHA 543613
T23145478149-53-0In house
PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.
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6-8 weeks
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Org 25543 hydrochloride
T22126495076-64-7
Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells.
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BAY 41-8543
T21712256498-66-5
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
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INCB054329
INCB-054329,INCB-54329, INCB-54329
T223451628607-64-6
INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2 with IC50 values of 44 nM, 5 nM, 9 nM, 1 nM, 28 nM, 3 nM, 119 nM and 63 nM respectively.
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10-14 weeks
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Org 25543
T50082363628-88-0
Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.
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GW 284543 hydrochloride
T7742179246-08-3
GW 284543 hydrochloride is a selective inhibitor of MEK5 .
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YM543 free base
T68922655237-16-4
YM543 free base, a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor, effectively reduces blood glucose levels and is suitable for diabetes research.
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8-10 weeks
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Gln-AMS TFA (209543-57-7 free base)
Gln-AMS TFA
T11403L
Gln-AMS(TFA) inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor.
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6-8 weeks
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INCB054329 Racemate
T116491628607-62-4
INCB054329 Racemate is an inhibitor of BET protein.
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6-8 weeks
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LY285434
T11910159748-08-0
LY285434 is an angiotensin II receptor antagonist [suitable].
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6-8 weeks
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TMU 35435
T2001712231800-32-9
TMU 35435 is an inhibitor of histone deacetylases (HDAC). It enhances radiosensitivity by inducing the accumulation of misfolded proteins and autophagy (autophagy) in TNBC, and inhibits the NHEJ pathway through ubiquitination of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).
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10-14 weeks
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BI1543673
T200483
BI1543673 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). It can diminish inflammatory responses in human lung tissue stimulated by TLR4 and TLR7 8. Additionally, BI1543673 reduces inflammatory signaling in a mouse lung inflammation model induced by LPS.
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NSC635437
NSC-635437, NSC 635437
T202413667914-33-2
NSC635437 acts as an inhibitor of the EWS-FLI1 oncoprotein in Ewing's sarcoma.
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ICI-125436
ICI125436, ICI 125436
T20280667631-88-3
ICI-125436 is a prodrug with anti-inflammatory properties.
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