5' deoxyadenosine

5'-chloro-5'-Deoxyadenosine (hydrate) is a nucleoside analog used as a substrate in polyketide biosynthesis. S-(5'-adenosyl)-L-methionine can be converted to 5'-chloro-5'-deoxyadenosine in a reaction catalyzed by a SAM-dependent chlorinase. Through a 7-step route, 5'-chloro-5'-deoxyadenosine can be converted to chloroethylmalonyl-CoA, which has been shown to be involved in the biosynthesis of the anticancer agent salinosporamide A in the marine bacterium S. tropica.

5'-Fluoro-5'-deoxyadenosine (5'-Fluoro-5'-deoxy-adenosine) is utilized commonly as a tool for studying the Actinomycete bacterium Streptomyces cattleya.

2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1dATP is a substrate for DNA polymerase in the synthesis of DNA.2It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations in the gene for adenosine deaminase, the enzyme that catalyzes the deamination of adenosine and deoxyadenosine.5 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Key steps in nucleotide biosynthesis are regulated by feedback inhibitionBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.DNA is replicated by polymerases that take instructions from templatesBiochemistry(2002) 3.Cadwell, R.C., and Joyce, G.F.Randomization of genes by PCR mutagenesisPCR Methods Appl.2(1)28-33(1992) 4.Steffens, D.L., Jang, G.Y., Sutter, S.L., et al.An infrared fluorescent dATP for labeling DNAGenome Res.5(4)393-399(1995) 5.Flinn, A.M., and Gennery, A.R.Adenosine deaminase deficiency: A reviewOrphanet J. Rare Dis.13(1)65(2018)

N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.

2'-Deoxyadenosine-5'-triphosphate-d14 (dATP-d14) dilithium is a deuterium-labeled version of 2'-Deoxyadenosine-5'-triphosphate. This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (dATP), is employed in cells for DNA synthesis or replication and acts as a substrate for DNA polymerase.

2'-Deoxyadenosine-5'-triphosphate-15N5 (dATP-15N5) dilithium is a version of 2'-Deoxyadenosine-5'-triphosphate that is labeled with nitrogen-15 (15N). This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (dATP), plays a crucial role in cellular processes as it is utilized in DNA synthesis or replication. Additionally, 2'-Deoxyadenosine-5'-triphosphate (dATP) serves as a substrate for DNA polymerase.

2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 (dATP-13C10,15N5) dilithium is the isotope-labeled form of 2'-Deoxyadenosine-5'-triphosphate with 13C and 15N. This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (dATP), plays a critical role in cells for DNA synthesis and replication, serving as a substrate for DNA polymerases.

2'-Deoxyadenosine-5'-monophosphate-d12dilithium is the deuterium-labeled version of 2'-Deoxyadenosine-5'-monophosphate. This compound, a derivative of nucleic acid AMP, is a deoxyribonucleotide found in DNA. It is utilized in the study of adenosine-based interactions during DNA synthesis and damage processes.

2'-Deoxyadenosine-5'-triphosphate-13C10 (dATP-13C10) dilithium is a 13C-labeled form of 2'-Deoxyadenosine-5'-triphosphate. This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (dATP), is utilized in cellular processes for DNA synthesis or replication and serves as a substrate for DNA polymerase.

4',5'-Didehydro-5'-deoxyadenosine is a Nucleoside Derivative - 5'-Modified nucleoside.

N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite, an adenine nucleoside analog, has potential vasodilator and anticancer activities relevant to cancer research.

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyadenosine is a Nucleoside Derivative - Protected nucleoside with NH2/OH open.

3'-O-tert-Butyldimethylsilyl-5'-O-DMT-2'-deoxyadenosine is a nucleoside derivative with an open NH2/OH group.

5'-O-DMTr-N6-ethyl-2'-deoxyadenosine 3'-CED phosphoramidite is a Nucleoside Phosphoramidite.

2'-Amino-2'-deoxyadenosine-5'-O-diphosphate (2'-NH2-ADP) sodium is an amine-modified nucleotide, serving as a structural analog of the purine nucleotide ADP.

3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium is an amine-modified nucleotide that can be utilized in the synthesis of other active compounds. Its coumarin-labeled derivative exhibits significant fluorescence changes when interacting with myosin, effectively mimicking the function of natural ADP.

2'-Deoxyadenosine 5'-triphosphate disodium (5'-Dexoadenosine triphosphate disodium) is a nucleotide with significant biological activity, serving as a substrate for various polymerases, such as DNA polymerase and reverse transcriptase. It plays a crucial role in both DNA synthesis and reverse transcription and is extensively used in vitro for molecular biology research.

Sp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) (Sp-dADP-α-S) sodium is an isomer of Rp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) sodium.

7-Deaza-2'-deoxyadenosine-5'-O-triphosphate (C7-dATP) tetrasodium is a derivative of ATP. ATP (Adenosine 5'-triphosphate) is a central component in energy storage and metabolism within the body.

Rp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) (Rp-dADP-α-S) sodium is an isomer of Sp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) sodium.

3′,5′-Bis-O-(tert-butyldimethylsilyl)-2′-deoxyadenosine is a pharmaceutical intermediate used in the synthesis of various active compounds.

Nucleoside Derivatives - Fluoro-modified nucleosides, 7-Deaza-purine nucleosides

Nucleoside Derivatives - Halo-nucleoside; 2'-Modified nucleoside, Protected nucleosides with NH2/OH open

Nucleoside Derivatives - Protected nucleosides with NH2/OH open; 3'-Modifed nucleosides; Used for conjugation