β antagonists

Celiprolol hydrochloride (Selectrol) is a cardioselective beta-1 adrenergic antagonist that has intrinsic sympathomimetic activity. It is used in the management of ANGINA PECTORIS and HYPERTENSION.

WEHL-04 is an intermediate used to prepare (isoquinolinylsulfonyl)benzoic acids as inhibitors of type 5 71-β-hydroxysteroid dehydrogenase AKR1C3. It is also used in the synthesis of 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists

CXCR2-IN-2 is a selective CXCR2 antagonist that is brain penetrant and orally bioavailable, with IC50 values of 5.2 nM and 1 nM in the β-arrestin assay and CXCR2 Tango assay, respectively. It exhibits approximately 730-fold selectivity over CXCR1 and greater than 1900-fold selectivity over all other chemokine receptors. Furthermore, CXCR2-IN-2 effectively inhibits Gro-α induced CD11b expression in human whole blood, displaying an IC50 of 0.04 μM[1].

Pindolol-d7 is a deuterated compound of Pindolol. Pindolol has a CAS number of 13523-86-9. Pindolol is a moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity.

23-O-β-D-Glucopyranosyl-20-isoveratramine, extracted from nettles, shows promise as an anti-allergic agent. Nettle extract contains a range of COX-1, COX-2, 5-lipoxygenase, and trypsin-like inhibitors, as well as H1 antagonists. These compounds collectively help mitigate symptoms of seasonal allergies, allergic rhinitis, and other inflammatory diseases, offering both treatment and preventive benefits [1].