Cepharanthine (NSC-623442) is a natural alkaloid that inhibits TNF-α-mediated NFκB stimulation, plasma membrane lipid peroxidation, and platelet aggregation, as well as cytokine production. Cepharanthine exhibits anti-inflammatory, antioxidant, and antitumor activities.
Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels.
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. 2. Crebanine can also decrease t
1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.
(-)-Corynoxidine is an AChE inhibitor derived from tubers of Stephania succifera. Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus strains in different degrees.
16-Oxoprometaphanine is a natural product of Stephania, Menispermaceae. The catalog number is TN6023 and the CAS number is 58738-31-1. 16-Oxoprometaphanine can be used as a reference standard.
Oblongine chloride may have potential haemodynamic effects, it can cause a dose-dependent reduction of systolic and diastolic blood pressure, and that these effects are not mediated by α²-adrenergic receptor stimulation.
Dehydrocrebanine has strong activity against promyelocytic leukemia cells (HL-60) with an IC50 of 2.14 ug/mL. It also shows potent antimalarial activity with an IC50 value of 70 ng/ml.
Dihydroepistephamiersine 6-acetate is a natural product for research related to life sciences. The catalog number is TN3850 and the CAS number is 57361-74-7.
Dicentrine is an alkaloid-enriched fraction and the primary alkaloid of the leaves of Ocotea puberula (Lauraceae), a native Brazilian plant traditionally used by Indigenous populations for skin affections, and dicentrine further demonstrates pharmacological activity as an α1-adrenoceptor antagonist in human hyperplastic prostate tissue. Dicentrine has been evaluated using radioligand binding assays with [3H]prazosin and in vitro isometric tension experiments, confirming functional α1-adrenoceptor involvement and supporting therapeutic relevance in disorders associated with prostate hyperplasia.