Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduc
Florosenine is a natural product of Senecio, Asteraceae. The catalog number is TN4068 and the CAS number is 16958-30-8. Florosenine can be used as a reference standard.
Sarracine N-oxide is a natural product of Senecio, Asteraceae. The catalog number is TN4952 and the CAS number is 19038-27-8. Sarracine N-oxide can be used as a reference standard.
Senecivernine is a natural product of Senecio, Asteraceae. The catalog number is TN4989 and the CAS number is 72755-25-0. Senecivernine can be used as a reference standard.
Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.
1-Decarboxy-3-oxo-ceanothic acid exhibits in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, mediated at least in part by induction of apoptosis. It is cytotoxic against OVCAR-3 and HeLa cancer cell lines with IC50 values of 2.8 and 6.6 microg mL, respectively, and has an IC50 of 11.3 microg mL against normal cell line FS-5.
4-Hydroxy-4-(methoxycarbonylmethyl)cyclohexanone is a natural product for research related to life sciences. The catalog number is TN3037 and the CAS number is 81053-14-7.
Prenatal exposure to Integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delayed in physical and behavioral development of the offspring. Doses of Integerrimine N-oxide here employed did not produce marked immunotoxic effects.
Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. It was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments.
Spartioidine is a natural product of Senecio, Asteraceae. The catalog number is TN5041 and the CAS number is 520-59-2. Spartioidine can be used as a reference standard.