Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduc
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a natural product isolated from Senecio scandens and exhibits notable anti-inflammatory activities.
Senecionine n-oxide is a major product of pyrrolizidine nucleic alkaloid biosynthesis in unusual root cultures of Trichoderma lucidum.Senecionine N-oxide (Senecionine oxide) has antitumor activity but induces hepatic sinusoidal obstruction syndrome.Senecionine n-oxide acts as a chelating tracer for N-oxide.
Florosenine is a natural product of Senecio, Asteraceae. The catalog number is TN4068 and the CAS number is 16958-30-8. Florosenine can be used as a reference standard.
Sarracine N-oxide is a natural product of Senecio, Asteraceae. The catalog number is TN4952 and the CAS number is 19038-27-8. Sarracine N-oxide can be used as a reference standard.
Senecivernine is a natural product of Senecio, Asteraceae. The catalog number is TN4989 and the CAS number is 72755-25-0. Senecivernine can be used as a reference standard.
Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.
1-Decarboxy-3-oxo-ceanothic acid exhibits in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, mediated at least in part by induction of apoptosis. It is cytotoxic against OVCAR-3 and HeLa cancer cell lines with IC50 values of 2.8 and 6.6 microg/mL, respectively, and has an IC50 of 11.3 microg/mL against normal cell line FS-5.
Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. It was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments.
Spartioidine is a natural product of Senecio, Asteraceae. The catalog number is TN5041 and the CAS number is 520-59-2. Spartioidine can be used as a reference standard.