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Cancer research

Tumor research dyes are a class of chemical reagents used to label and detect tumor cells, which can target specific structural or functional characteristics of tumor cells, such as membrane proteins, enzyme activity or acidic environment. These dyes are widely used in tumor imaging, drug screening and efficacy evaluation.

  • MKT-077
    T5152147366-41-4
    MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 μM in vitro) through its ability to inhibit members of the Hsp70 family of molecular chaperones.
    • $31
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  • Methylene Blue trihydrate
    T00067220-79-3
    Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate is used as a bacteriologic stain and as an indicator. It inhibits soluble guanylyl cyclase and has been used to treat cyanide poisoning and to lower levels of methemoglobin. It also inhibits tau filament formation (IC50: 1.9μM).
    • $36
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  • Indigo carmine
    T19755860-22-0
    Indigo carmine (NSC-8646) is an indolesulfonic acid. It is used as a dye in renal function testing for the detection of nitrates and chlorates.
    • $30
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  • Naphthofluorescein
    T3695361419-02-1
    Naphthofluorescein (Naphthafluorescein) is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhibits glycolytic activity in cancer cells and macrophages without showing significant in vitro cytotoxicity or in vivo side effects. Naphthofluorescein is also a fluorescent pH-sensitive probe for functional Cherenkov imaging.
    • $44
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  • MHI-148
    T77553172971-76-5
    MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection, diagnosis, and study of cancer.MHI-148 is taken up and accumulates in the lysosomes and mitochondria of tumor cells but is not taken up in the lysosomes and mitochondria of normal cells.MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection and diagnosis of cancer.
    • $35
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  • IR-783
    TD0106115970-66-6
    IR 783 is a heptamethine cyanine fluorescent probe for in vivo imaging of tumor cells. It displays excitation/emission maxima of 776/798 nm, respectively.
    • $30
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  • Isosulfan blue
    T1559868238-36-8
    Isosulfan blue is a blue dye utilized for identifying lymph vessels during lymphangiography and sentinel lymph node biopsies in breast cancer. However, Isosulfan blue may cause allergic reactions during breast cancer operations [1] [2].
    • $30
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    TargetMol | Inhibitor Sale
  • 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylethanolamine
    T8121661216-62-4
    1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylethanolamine (SAPE) is a natural phospholipid found in mitochondrial inner membranes, involved in lipid signaling.
    • $243
    35 days
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  • Pegulicianine acetate
    T880142230217-18-0
    Pegulicianine acetate (LUM015) serves as a potent fluorescent imaging agent for detecting cancer tissue.
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  • S0456
    T873501252007-83-2
    S0456, a near-infrared (NIR) fluorescent dye, binds to the folate receptor (FR) and is utilized in the synthesis of Pafolacianine. It serves as a tumor-specific optical imaging agent with an excitation wavelength of 788 nM and an emission wavelength of 800 nM [1].
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  • RTSPSSR
    T873461995062-44-6
    RTSPSSR is a synthesized peptide that specifically binds to claudin-1 and visualizes CRC tumors in mice through near-infrared fluorescence imaging [1].
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  • Fluoromisonidazole
    T3182513551-89-8
    Fluoromisonidazole, a Radiation-Sensitizing Agent, can be used for imaging tumor hypoxia: imaging the microenvironment for personalized cancer therapy.
    • $1,520
    6-8 weeks
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  • HMRG
    T899411629965-68-9
    HMRG is a hydroxymethyl rhodamine green fluorescent scaffold featuring an open non-spirocyclic structure. At physiological pH, HMRG undergoes a one-step enzymatic reaction resulting in significant dynamic fluorescence changes, making it suitable for developing various probes. Fluorescent probes based on HMRG can be utilized for detecting diseases such as cancer and diabetic nephropathy.
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  • BIBD-300
    T858533030758-22-3
    BIBD-300 is a high-affinity PARP-1 imaging agent capable of accurately localizing C6 and U87MG tumors, making it suitable for research in diagnosing breast cancer, prostate cancer, glioma, and liver cancer [1].
    • $1,680
    6-8 weeks
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  • HPI
    T86589210541-64-3
    HPI is an HS-fluorescent probe (Ex Em=280 410 nm) that can be utilized to detect the HS- form of hydrogen sulfide (H2S) gas in environmental water samples [1].
    • $1,520
    4-6 weeks
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  • PNE-Lyso
    T81434
    PNE-Lyso is an activatable fluorescent probe capable of detecting intracellular pH and hexosaminidases via dual fluorescence signals. It distinguishes apoptosis from necrosis by visualizing lysosomal morphology and facilitates the investigation of agent-induced cell death processes [1].
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  • Naphthol AS-TR phosphate disodium
    T869634264-93-1
    Naphthol AS-TR Phosphate disodium, a water-soluble dye, serves as an enzymatic substrate in biochemical assays to measure alkaline phosphatase activity. Its unique chemical properties enable hydrolysis by alkaline phosphatase, resulting in a colored product detectable spectrophotometrically. This characteristic renders it valuable for assessing enzyme activity in biological samples, including serum and urine.
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  • Imatinib Acid
    T19015
    Imatinib Acid is usually used as a fluorescent probe or labeled chemical.
    • $1,520
    6-8 weeks
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  • HS-131
    T394912084850-40-6
    HS-131, a near-infrared dye-conjugated Hsp90 inhibitor, effectively identifies oncogene-driven breast cancers across various molecular subtypes.
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  • LDN-211904
    T880711198408-39-7
    LDN-211904 acts as an inhibitor of the EphB3 receptor tyrosine kinase. It increases the inhibition of EphB3 kinase by preserving the 2-chloroaniline group and adding either a phenyl or a small electron donor substituent to the 5 position of pyrazole and [1,5-a] pyridine. LDN-211904 serves as a molecular probe for investigating the function and signaling pathways of EphB3 receptors, particularly within the nervous system throughout neurodevelopment and adulthood.
    • $1,520
    6-8 weeks
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  • LE 28
    T819451416080-97-1
    LE 28 is a selective, activity-dependent probe for legumain that fluoresces exclusively upon binding to the active enzyme. It is applicable in research on cancers and inflammatory diseases [1].
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  • Pafolacianine
    T391031628423-76-6
    Pafolacianine (OTL 38) is a near-infrared dye-based fluorescent marker used to identify ovarian cancer lesions during surgeries.
    • $1,520
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  • Photoacoustic contrast agent-1 perchlorate
    T884322255329-07-6
    Photoacoustic contrast agent-1 perchlorate (Compound F-1) serves as a photo/sono-sensitizer that effectively induces cell mortality under illuminated conditions. This compound is applied in the field of tumor diagnostics and treatment research. Additionally, it acts as a multifunctional dye, which is crucial in various biological experiments. These dyes facilitate the observation and analysis of cell structures, tracking of biomolecules, evaluation of cell functions, differentiation of cell types, detection of biomolecules, investigation of tissue pathology, and monitoring of microorganisms. Their uses extend beyond basic scientific research to include a broad spectrum of clinical diagnostics. Moreover, dyes play a significant role in conventional areas like textile dyeing and in newer sectors such as functional textile processing, food pigments, and dye-sensitized solar cells.
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    • SW116 free base
      T896151036759-00-8
      SW116 free base is a selective fluorescent ligand for the sigma-2 receptor (sigma-2 receptor), with a Ki of 14 nM. It exhibits a maximum excitation wavelength of 333 nM and a maximum emission wavelength of 506 nM in methanol. SW116 free base can internalize into MDA-MB-435 cells, reaching 50% of its maximum fluorescence intensity within 24 minutes. This compound serves as a fluorescent probe in cancer research.
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