Search Result

Search Results for " p38-mapk "

Targets

107

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T36010	p38 MAPK Inhibitor		p38 MAPK
	p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.		p38 MAPK
T12347	p38-α MAPK-IN-1		p38 MAPK , Autophagy
	p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor(IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay).		p38 MAPK , Autophagy
T35420	(S)-p38 MAPK Inhibitor III	(S)-p38 MAPK Inhibitor III
	(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononucle...
T16424	p38 MAPK-IN-1		p38 MAPK
	p38 MAPK-IN-1 displays sustained levels, low clearance, and good bioavailability. p38 MAPK-IN-1 is a novel effective and selective inhibitor of p38 MAPK (IC50: 68 nM).		p38 MAPK
T36011	p38 MAP Kinase Inhibitor IV	p38 MAPK Inhibitor IV
	p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α an...
T11241	p38 MAPK-IN-2		Others
	p38 MAPK-IN-2 is an inhibitor of p38 kinase.		Others
T70638	p38-α MAPK-IN-5
	P38-α MAPK-IN-5 is a potent inhibitor of p38α, demonstrating inhibitory concentrations (IC50) of 0.1 nM for p38α, 0.2 nM for p38β, 944 nM for p38γ, and 4100 nM for p38δ. It exhibits anti-inflammatory properties and holds...
T9697	ASK1-IN-1		ASK
	ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.		ASK
T2513	VX-702		p38 MAPK , Autophagy
	VX-702 is a highly specific p38α MAPK inhibitor, 14-fold higher selectivity for the p38α than p38β. VX-702 is a small molecule investigational oral anti-cytokine therapy for treatment of inflammatory diseases, specifical...		p38 MAPK , Autophagy
T10277	AL 8697		p38 MAPK
	AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity.		p38 MAPK
T1974	PH-797804	PH797804	p38 MAPK , Autophagy
	PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.		p38 MAPK , Autophagy
T6976	SB 239063	SB239063	p38 MAPK , Autophagy
	SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.		p38 MAPK , Autophagy
T4645	TA-01		p38 MAPK , Casein Kinase , Autophagy
	TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.		p38 MAPK , Casein Kinase , Autophagy
T14381	AZD7624	AZD-7624	p38 MAPK , TNF
	AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.		p38 MAPK , TNF
T61803	p38 MAPK-IN-3
	p38 MAPK-IN-3 (Compound 2c) is a potent inhibitor of p38α MAPK, displaying antitumor properties by promoting apoptosis and increasing reactive oxygen species (ROS) production [1].
T4078	SB 242235	SB-242235,SB242235	p38 MAPK , Autophagy
	SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.		p38 MAPK , Autophagy
T6934	Pexmetinib	ARRY-614	Tie-2 , p38 MAPK , Autophagy
	Pexmetinib (ARRY-614) (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.		Tie-2 , p38 MAPK , Autophagy
T7367	Acumapimod	BCT-197	p38 MAPK , Autophagy
	Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).		p38 MAPK , Autophagy
T6089	Neflamapimod	VX-745	p38 MAPK , Autophagy
	Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.		p38 MAPK , Autophagy
T61091	p38-α MAPK-IN-4
	p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM. It effectively and swiftly mitigates the onset of mechanical allodynia (MA) in vivo [1].
T22115	SM-7368		NF-κB
	The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.		NF-κB
T2432	PD 169316		Virus Protease , p38 MAPK , Autophagy
	PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.		Virus Protease , p38 MAPK , Autophagy
T7661	SD-169	SD 169	p38 MAPK
	SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.		p38 MAPK
T6130	Skepinone-L	CBS3830	p38 MAPK , Autophagy
	Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.		p38 MAPK , Autophagy
T12979	BI-3406		p38 MAPK , MAPK , Ras
	BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.		p38 MAPK , MAPK , Ras
T5494	MW-150	MW01-18-150SRM	p38 MAPK , Autophagy
	MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.		p38 MAPK , Autophagy
T2367	SKF-86002	SKF86002	p38 MAPK , TNF
	SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).		p38 MAPK , TNF
T4597	UM-164	UM164,DAS-DFGO-II	p38 MAPK , Src , Autophagy
	UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.		p38 MAPK , Src , Autophagy
T50005	Sertaconazole		Antifungal
	Sertaconazole is a broad-spectrum antifungal.		Antifungal
T11898	LXH254		Raf
	LXH254 is a potent C-Raf and B-Raf inhibitor.		Raf
T2301	SB 202190	FHPI,SB202190	Apoptosis , p38 MAPK , Autophagy
	SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably. SB 202190 has antitumor activity and also induces the differentiation of human embryonic stem cells i...		Apoptosis , p38 MAPK , Autophagy
T12997	SR-318		p38 MAPK , TNF
	SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and anti-inflammatory activity.		p38 MAPK , TNF
T12871	Talmapimod	SCIO-469	p38 MAPK
	Talmapimod (SCIO-469) is an selective, orally active, and ATP-competitive p38α inhibitor with IC50 of 9 nM and 90 nM for p38α and p38β, respectively. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 ...		p38 MAPK
T6277	Doramapimod	BIRB 796	Raf , p38 MAPK , Autophagy
	Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.		Raf , p38 MAPK , Autophagy
T4646	TA-02		p38 MAPK , Autophagy
	TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.		p38 MAPK , Autophagy
T16159	Muramyl dipeptide	MDP	NOD
	Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation...		NOD
T6150	TAK-715		p38 MAPK , Casein Kinase , JNK
	TAK-715 is a p38 MAPK inhibitor for p38α.		p38 MAPK , Casein Kinase , JNK
T7123	AMG-47a		VEGFR , p38 MAPK , JAK , Src
	AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protei...		VEGFR , p38 MAPK , JAK , Src
T3462	BMS-582949 hydrochloride	BMS-582949 HCl	p38 MAPK , Autophagy
	The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).		p38 MAPK , Autophagy
T16501	PF-3644022		p38 MAPK , Serine Protease , MAPK
	PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib...		p38 MAPK , Serine Protease , MAPK
T12850	Dilmapimod	SB-681323,GW 681323	p38 MAPK , Autophagy
	Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.		p38 MAPK , Autophagy
T16812	RWJ-67657	JNJ 3026582	p38 MAPK
	RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor (IC50s: 1 and 11 μM, respectively). RWJ-67657 shows no activity at p38γ and p38δ and shows a cardioprotective effect.		p38 MAPK
T6047	Ralimetinib dimesylate	LY2228820 dimesylate,Ralimetinib,LY2228820,Ralimetinib Mesylate	Apoptosis , p38 MAPK , Autophagy
	Ralimetinib dimesylate (LY2228820 dimesylate) is the dimesylate salt form of LY2228820, a tri-substituted imidazole derivative and orally available, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential an...		Apoptosis , p38 MAPK , Autophagy
T6927	Pamapimod	R1503,Ro4402257	p38 MAPK , Autophagy
	Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectiv...		p38 MAPK , Autophagy
T7276	SD 0006	SD-06	p38 MAPK , Autophagy
	SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.		p38 MAPK , Autophagy
T12352L	Oxidopamine hydrobromide	6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T12352	Oxidopamine hydrochloride	6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T6665	Sertaconazole nitrate	FI-7045,Ginedermofix,FI7056,Ertaczo	Antibiotic , Antifungal
	Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections.		Antibiotic , Antifungal
T0005	Aspirin	Acetylsalicylate,Acetylsalicylic Acid,ASA	Mitophagy , Virus Protease , COX , Autophagy
	Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel...		Mitophagy , Virus Protease , COX , Autophagy
T2277	Losmapimod	GSK-AHAB,GW856553X,GW856553,SB856553	p38 MAPK , Autophagy
	Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).		p38 MAPK , Autophagy

Compounds

p38 MAPK Inhibitor

Target: p38 MAPK, Autophagy

(S)-p38 MAPK Inhibitor III

T35420

Synonym: (S)-p38 MAPK Inhibitor III

p38 MAP Kinase Inhibitor IV

T36011

Synonym: p38 MAPK Inhibitor IV

Target: p38 MAPK, Autophagy

Target: p38 MAPK, Autophagy

SB 239063

T6976

Synonym: SB239063

Target: p38 MAPK, Autophagy

TA-01

T4645

Synonym:

Target: p38 MAPK, Casein Kinase, Autophagy

AZD7624

T14381

Synonym: AZD-7624

Target: p38 MAPK, TNF

Synonym: SB-242235,SB242235

Target: p38 MAPK, Autophagy

Pexmetinib

T6934

Synonym: ARRY-614

Target: Tie-2, p38 MAPK, Autophagy

Acumapimod

T7367

Synonym: BCT-197

Target: p38 MAPK, Autophagy

Neflamapimod

T6089

Synonym: VX-745

Target: p38 MAPK, Autophagy

Target: Virus Protease, p38 MAPK, Autophagy

Target: p38 MAPK, Autophagy

BI-3406

T12979

Synonym:

Target: p38 MAPK, MAPK, Ras

MW-150

T5494

Synonym: MW01-18-150SRM

Target: p38 MAPK, Autophagy

SKF-86002

T2367

Synonym: SKF86002

Target: p38 MAPK, TNF

UM-164

T4597

Synonym: UM164,DAS-DFGO-II

Target: p38 MAPK, Src, Autophagy

Synonym: FHPI,SB202190

Target: Apoptosis, p38 MAPK, Autophagy

SR-318

T12997

Synonym:

Target: p38 MAPK, TNF

Target: Raf, p38 MAPK, Autophagy

TA-02

T4646

Synonym:

Target: p38 MAPK, Autophagy

Target: p38 MAPK, Casein Kinase, JNK

AMG-47a

T7123

Synonym:

Target: VEGFR, p38 MAPK, JAK, Src

BMS-582949 hydrochloride

T3462

Synonym: BMS-582949 HCl

Target: p38 MAPK, Autophagy

PF-3644022

T16501

Synonym:

Target: p38 MAPK, Serine Protease, MAPK

Dilmapimod

T12850

Synonym: SB-681323,GW 681323

Target: p38 MAPK, Autophagy

Ralimetinib dimesylate

T6047

Synonym: LY2228820 dimesylate,Ralimetinib,LY2228820,Ralimetinib Mesylate

Target: Apoptosis, p38 MAPK, Autophagy

Pamapimod

T6927

Synonym: R1503,Ro4402257

Target: p38 MAPK, Autophagy

SD 0006

T7276

Synonym: SD-06

Target: p38 MAPK, Autophagy

Oxidopamine hydrobromide

T12352L

Synonym: 6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide

Target: Mitophagy, Dopamine Receptor, Autophagy

Oxidopamine hydrochloride

T12352

Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride

Target: Mitophagy, Dopamine Receptor, Autophagy

Sertaconazole nitrate

T6665

Synonym: FI-7045,Ginedermofix,FI7056,Ertaczo

Target: Antibiotic, Antifungal

Aspirin

T0005

Synonym: Acetylsalicylate,Acetylsalicylic Acid,ASA

Target: Mitophagy, Virus Protease, COX, Autophagy

Losmapimod

T2277

Synonym: GSK-AHAB,GW856553X,GW856553,SB856553

Target: p38 MAPK, Autophagy

Cat No.	Product Name	Synonyms	Targets
TN1445	Bisabolangelone		p38 MAPK , MAPK
	Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.		p38 MAPK , MAPK
T3400	Bakuchiol		p38 MAPK , DNA/RNA Synthesis , Autophagy
	Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymerase1 inhibiting activity. Bakuchiol has anti-bacterial activity against oral pathogens, has great pot...		p38 MAPK , DNA/RNA Synthesis , Autophagy
T5S2283	Sesamolin		p38 MAPK , Caspase , JNK
	1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 activation and ROS production. 3. Sesamolin and Sesamin can s...		p38 MAPK , Caspase , JNK
T2565	Hesperetin		Apoptosis , p38 MAPK , 5-HT Receptor , Autophagy , TGF-beta/Smad
	Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
TN1721	Gypenoside L		ERK , p38 MAPK , Calcium Channel , NF-κB , ROS
	Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a...		ERK , p38 MAPK , Calcium Channel , NF-κB , ROS
T3860	Isoliquiritin apioside		MMP , p38 MAPK , NF-κB
	Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse...		MMP , p38 MAPK , NF-κB
T2885	Esculin	Aesculin	Antiviral , p38 MAPK , Antibacterial
	Esculin (Aesculin) is a glucoside found in horse chestnuts.		Antiviral , p38 MAPK , Antibacterial
TN1968	N-Feruloyloctopamine	N-Feruloyloctopamine	p38 MAPK , Akt
	N-Feruloyloctopamine is a natural product.		p38 MAPK , Akt
T0539	Dihydrocaffeic acid	Hydrocaffeic acid	Antioxidant , p38 MAPK , Endogenous Metabolite
	Dihydrocaffeic acid (Hydrocaffeic acid), a metabolite of chlorogenic acid, is a well-known anti-oxidant component, has anti-oxidative, anti-Alzheimer's, neuroprotective, arousal, and lipid-lowering effects.		Antioxidant , p38 MAPK , Endogenous Metabolite
T7051	5,6,7-TRIMETHOXYFLAVONE	Baicalein Trimethyl Ether	p38 MAPK
	5,6,7-Trimethoxyflavone, a natural product extracted from Japanese Callicarpa, acts as a p38-α MAPK inhibitor and exhibits anti-inflammatory properties.		p38 MAPK
T5S0506	Rotundic acid	Rutundic acid	Apoptosis , Others , p38 MAPK , Akt , mTOR
	Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c...		Apoptosis , Others , p38 MAPK , Akt , mTOR
T5S2358	Dehydrocorydaline	Dehydrocorydalin,13-Methylpalmatine	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T5S0089	Kaempferol-3-O-glucorhamnoside	Kaempferol 3-glucorhamnoside	Antioxidant , p38 MAPK , NF-κB
	Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPK and NF-κB pathways in vitro and in vivo[1]. Kaempferol-3-O-gl...		Antioxidant , p38 MAPK , NF-κB
T5S0761	Nitidine chloride		Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite
	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id...
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
T10990	Dehydrocorydaline chloride	13-Methylpalmatine chloride	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T2S2362	Dehydrocorydaline nitrate		BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a...
T6427	Butein	2’,3,4,4’-tetrahydroxy Chalcone	Apoptosis , EGFR , Others , PDE , Autophagy
	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.		Apoptosis , EGFR , Others , PDE , Autophagy
TL0004	FERULIC ACID METHYL ESTER	Methyl ferulate,Methyl 4'-hydroxy-3'-methoxycinnamate	p38 MAPK , Autophagy
	FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that p...		p38 MAPK , Autophagy
T9218	Andrograpanin	19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE	p38 MAPK
	Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) is a bioactive compound from Andrographis paniculata. Andrograpanin has anti-inflammatory and anti-infectious properties.		p38 MAPK
T5281	Skatole	Scatole,3-Methylindole,3-Methylindole,3-Methyl-1H-indole,beta-Methylindole	AhR , p38 MAPK , Aryl Hydrocarbon Receptor , Endogenous Metabolite , Antibacterial , Autophagy , Antifungal
	Skatole (3-Methyl-1H-indole) is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
T2755	Rhoifolin	Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside	Others , p38 MAPK , NF-κB , transporter , IGF-1R , Autophagy
	Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.
T4085	Paris saponin VII	Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T10383	Asatone		NF-κB
	Asatone, an active component isolated from Radix et Rhizoma Asari, has an anti-inflammatory effect via activation of NF-κB and downregulation of p-MAPK (ERK, JNK, and p38) pathways.		NF-κB
T3908	10-Gingerol		Apoptosis
	10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, p38 MAPK (p38), c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK).		Apoptosis
T3896	Shanzhiside methyl ester		Glucagon Receptor
	Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling.		Glucagon Receptor
T3008	Lawsone methyl ether	2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone	Apoptosis , Antibacterial , Antifungal
	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated that these s...		Apoptosis , Antibacterial , Antifungal
T5S1058	Triptonide	PG 492,NSC 165677	Apoptosis , Wnt/beta-catenin , Autophagy
	1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-inflammatory activity, upregulate the expression of IL-37, an...		Apoptosis , Wnt/beta-catenin , Autophagy
T3763	Fumaric acid	Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,Donitic acid,Allomaleic acid	Endogenous Metabolite
	Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or a...		Endogenous Metabolite
T2768	Saikosaponin A		NF-κB , Antibacterial , Liver X Receptor
	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath...		NF-κB , Antibacterial , Liver X Receptor
T3676	Sesamol	1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol	Apoptosis , AMPK
	Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 sig...		Apoptosis , AMPK
TN5888	Toddaculin		Others
	Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in...		Others
T3923	Calycosin	Cyclosin,3'-Hydroxyformononetin	Apoptosis , Tyrosinase
	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...		Apoptosis , Tyrosinase
T6S1538	Neochlorogenic acid	trans-5-O-Caffeoylquinic acid,Neochlorogenate,5-O-Caffeoylquinic acid	TNF , NF-κB , COX , Antibacterial , Interleukin
	Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.		TNF , NF-κB , COX , Antibacterial , Interleukin
T6429	Caffeic Acid Phenethyl Ester	Phenylethyl Caffeate,CAPE	Apoptosis , NF-κB
	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective...		Apoptosis , NF-κB
T3S0737	Flavokawain A	Flavokavain A	Apoptosis , p38 MAPK
	NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant...		Apoptosis , p38 MAPK
T6S1572	Sauchinone		ERK , p38 MAPK , NF-κB
	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative...		ERK , p38 MAPK , NF-κB
T3669	Curcumenol	(+)-Curcumenol	P450
	Curcumenol ((+)-Curcumenol), one of the major components of Zedoary turmeric oil, is an antibiotic drug which has anti-Y, anti-inflammation activity. Curcumenol may be safely used without inducing metabolic drug-drug int...		P450
TN5174	Trichosanatine		MMP , LDL , p38 MAPK , Lipoxygenase , ROS
	Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine can alleviate oxidized low-density lipoprotein induced end...		MMP , LDL , p38 MAPK , Lipoxygenase , ROS
T12667	(Rac)-Hesperetin		Others
	(Rac)-Hesperetin is the racemate form of of Hesperetin. Hesperetin is a natural flavanone compound, and it exhibits potent inhibitory effects against human UGT activity, making it a broad-spectrum inhibitor. Furthermore,...		Others
TN4635	Neoechinulin A		NADPH-oxidase , Beta Amyloid , ASK , IκB/IKK , p38 MAPK , TNF , NOS , NF-κB , COX , Prostaglandin Receptor
	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) ...
TN5387	Grasshopper ketone		ERK , p38 MAPK , NO Synthase , JNK
	Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory effects by inhibiting MAPK (ERK, JNK and p38) and NF-κB p65 ...		ERK , p38 MAPK , NO Synthase , JNK
TN2039	Panaxydol		cAMP , p38 MAPK , JNK
	Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through ...		cAMP , p38 MAPK , JNK
T75561	Chloranthalactone B
	Chloranthalactone B, a lindenane-type sesquiterpenoid derived from the Chinese medicinal herb Sarcandra glabra, acts as an inhibitor of inflammatory mediator production through the suppression of the AP-1 and p38 MAPK pa...
TN3541	Broussonin E		ERK , p38 MAPK , TNF , JAK , STAT
	Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway, and can be further developed as a promising drug for the...		ERK , p38 MAPK , TNF , JAK , STAT
TN5050	Sprengerinin C		NADPH-oxidase , VEGFR , p38 MAPK , ROS , Akt , PI3K , mTOR , p53
	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein ...
TN5901	Cudratricusxanthone A
	Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to in...

Natural Products

Bisabolangelone

TN1445

Synonym:

Target: p38 MAPK, MAPK

Bakuchiol

T3400

Synonym:

Target: p38 MAPK, DNA/RNA Synthesis, Autophagy

Sesamolin

T5S2283

Synonym:

Target: p38 MAPK, Caspase, JNK

Hesperetin

T2565

Synonym:

Target: Apoptosis, p38 MAPK, 5-HT Receptor, Autophagy, TGF-beta/Smad

Gypenoside L

TN1721

Synonym:

Target: ERK, p38 MAPK, Calcium Channel, NF-κB, ROS

Isoliquiritin apioside

T3860

Synonym:

Target: MMP, p38 MAPK, NF-κB

Esculin

T2885

Synonym: Aesculin

Target: Antiviral, p38 MAPK, Antibacterial

N-Feruloyloctopamine

TN1968

Synonym: N-Feruloyloctopamine

Target: p38 MAPK, Akt

Dihydrocaffeic acid

T0539

Synonym: Hydrocaffeic acid

Target: Antioxidant, p38 MAPK, Endogenous Metabolite

5,6,7-TRIMETHOXYFLAVONE

T7051

Synonym: Baicalein Trimethyl Ether

Target: p38 MAPK

Rotundic acid

T5S0506

Synonym: Rutundic acid

Target: Apoptosis, Others, p38 MAPK, Akt, mTOR

Dehydrocorydaline

T5S2358

Synonym: Dehydrocorydalin,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Kaempferol-3-O-glucorhamnoside

T5S0089

Synonym: Kaempferol 3-glucorhamnoside

Target: Antioxidant, p38 MAPK, NF-κB

Nitidine chloride

T5S0761

Synonym:

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Cornuside

T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Dehydrocorydaline chloride

T10990

Synonym: 13-Methylpalmatine chloride

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Dehydrocorydaline nitrate

T2S2362

Synonym:

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Butein

T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone

Target: Apoptosis, EGFR, Others, PDE, Autophagy

FERULIC ACID METHYL ESTER

TL0004

Synonym: Methyl ferulate,Methyl 4'-hydroxy-3'-methoxycinnamate

Target: p38 MAPK, Autophagy

Andrograpanin

T9218

Synonym: 19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE

Target: p38 MAPK

Skatole

T5281

Synonym: Scatole,3-Methylindole,3-Methylindole,3-Methyl-1H-indole,beta-Methylindole

Target: AhR, p38 MAPK, Aryl Hydrocarbon Receptor, Endogenous Metabolite, Antibacterial, Autophagy, Antifungal

Rhoifolin

T2755

Synonym: Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside

Target: Others, p38 MAPK, NF-κB, transporter, IGF-1R, Autophagy

Paris saponin VII

T4085

Synonym: Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Shanzhiside methyl ester

T3896

Synonym:

Target: Glucagon Receptor

Lawsone methyl ether

T3008

Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone

Target: Apoptosis, Antibacterial, Antifungal

Triptonide

T5S1058

Synonym: PG 492,NSC 165677

Target: Apoptosis, Wnt/beta-catenin, Autophagy

Fumaric acid

T3763

Synonym: Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,Donitic acid,Allomaleic acid

Target: Endogenous Metabolite

Saikosaponin A

T2768

Synonym:

Target: NF-κB, Antibacterial, Liver X Receptor

Sesamol

T3676

Synonym: 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol

Target: Apoptosis, AMPK

Synonym: Cyclosin,3'-Hydroxyformononetin

Target: Apoptosis, Tyrosinase

Neochlorogenic acid

T6S1538

Synonym: trans-5-O-Caffeoylquinic acid,Neochlorogenate,5-O-Caffeoylquinic acid

Target: TNF, NF-κB, COX, Antibacterial, Interleukin

Caffeic Acid Phenethyl Ester

T6429

Synonym: Phenylethyl Caffeate,CAPE

Target: Apoptosis, NF-κB

Flavokawain A

T3S0737

Synonym: Flavokavain A

Target: Apoptosis, p38 MAPK

Sauchinone

T6S1572

Synonym:

Target: ERK, p38 MAPK, NF-κB

Curcumenol

T3669

Synonym: (+)-Curcumenol

Target: MMP, LDL, p38 MAPK, Lipoxygenase, ROS

Target: NADPH-oxidase, Beta Amyloid, ASK, IκB/IKK, p38 MAPK, TNF, NOS, NF-κB, COX, Prostaglandin Receptor

Grasshopper ketone

TN5387

Synonym:

Target: ERK, p38 MAPK, NO Synthase, JNK

Panaxydol

TN2039

Synonym:

Target: cAMP, p38 MAPK, JNK

Target: ERK, p38 MAPK, TNF, JAK, STAT

Sprengerinin C

TN5050

Synonym:

Target: NADPH-oxidase, VEGFR, p38 MAPK, ROS, Akt, PI3K, mTOR, p53

Cudratricusxanthone A

TN5901

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04539	ERK2 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, diffe...
TMPY-04551	p38 delta/MAPK13 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	The p38 family of mitogen-activated protein kinases (MAPK) includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms tha...
TMPY-04531	p38 delta/MAPK13 Protein, Human, Recombinant (GST), Activated in vitro	Human	Baculovirus-Insect Cells
	The p38 family of mitogen-activated protein kinases (MAPK) includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms tha...
TMPY-04430	p38 gamma/MAPK12 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/t...
TMPY-04429	p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/t...
TMPY-05176	AMH Protein, Human, Recombinant (His)	Human	HEK293
	Anti-Mullerian hormone (AMH), a member of the TGF-beta superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and ...
TMPY-04572	MKK4 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is...
TMPK-00696	PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)	Human	Baculovirus-Insect Cells
	The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-...
TMPY-04378	MAPKAPK3 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases ...
TMPY-04425	PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated...
TMPH-01338	Fibronectin Protein, Human, Recombinant (His)	Human	E. coli
	Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell s...
TMPJ-01433	Fibronectin Protein, Human, Recombinant (ED-B domain, Avi & His), Biotinylated	Human	E. coli
	Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Similar to integrins, fibronectin binds extracellular matrix components ...
TMPY-01033	IL-32 Protein, Human, Recombinant (isoform alpha, His)	Human	HEK293
	IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathw...
TMPY-04374	MST4 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains ...
TMPY-04001	Angiopoietin-like 7 Protein, Canine, Recombinant (His)	Canine	HEK293
	ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...
TMPY-04391	Lyn Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many f...
TMPY-04000	Angiopoietin-like 7 Protein, Canine, Recombinant (hFc)	Canine	HEK293
	ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...
TMPY-04004	Angiopoietin-like 7 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...