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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN5912 Macluraxanthone 5848-14-6 98%
Macluraxanthone
Macluraxanthone (3-Hydroxyblancoxanthone) has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory a...
TN2588 11-Hydroxytephrosin 72458-85-6 98%
11-Hydroxytephrosin
11-Hydroxytephrosin inhibits NF-kappaB activity.
TN1212 2-Hydroxyeupatolide 72229-33-5 98%
2-Hydroxyeupatolide
2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and m...
TN3495 Benzyl ferulate 132335-97-8 98%
Benzyl ferulate
Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE...
TN4064 Flavoglaucin 523-73-9 98%
Flavoglaucin
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TMA1409 Cis-Mulberroside A 166734-06-1 98%
cis-Mulberroside A
cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.
TN5238 Viscidulin II 92519-93-2 98%
Viscidulin II
Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β produ...
TN4303 Isokaempferide 1592-70-7 98%
Isokaempferide
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by red...
TN3453 Arteannuin N 207446-92-2 98%
Arteannuin N
Arteannuin N has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
TN3119 5-Hydroxy-7,8-dimethoxyflavanone 113981-49-0 98%
5-Hydroxy-7,8-dimethoxyflavanone
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
TN1232 5,7-Dimethoxyflavanone 1277188-85-8 98%
5,7-Dimethoxyflavanone
5,7-Dimethoxyflavanone has anti-inflammatory activity.
TN1793 Isorhamnetin 3-O-galactoside 6743-92-6 98%
Isorhamnetin 3-O-galactoside
Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
TN4561 N-Decyl-4-methoxyaniline 733-40-4 98%
N-Decyl-4-methoxyaniline
Methylnissolin is a natural product from A. membranaceus.
TN4489 Manassantin A 88497-87-4 98%
Manassantin A
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN3325 9-O-Feruloyl-5,5'-dimethoxylariciresinol 166322-14-1 98%
9-O-Feruloyl-5,5'-dimethoxylariciresinol
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cyt...
TN3741 Cyclocurcumin 153127-42-5 98%
Cyclocurcumin
Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rh...
T19250 CRIPGBM 2361988-76-1 98%
cRIPGBM
cRIPGBM, a proapoptotic derivative of RIPGBM, selectively induces apoptosis in GBM cancer stem cells (CSCs) by targeting receptor-interacting protein kinase 2 (R...
TN3537 Braylin 6054-10-0 98%
Braylin
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition ...
TN3839 Desoxo-narchinol A 53859-06-6 98%
Desoxo-narchinol A
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TN4243 Hyuganin D 77331-76-1 98%
Hyuganin D
Hyuganin D can inhibit LPS-induced NO and/or TNF-alpha production in mouse peritoneal macrophages.
Macluraxanthone
TN5912
Macluraxanthone (3-Hydroxyblancoxanthone) has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory a...
11-Hydroxytephrosin
TN2588
11-Hydroxytephrosin inhibits NF-kappaB activity.
2-Hydroxyeupatolide
TN1212
2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and m...
Benzyl ferulate
TN3495
Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE...
Flavoglaucin
TN4064
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
cis-Mulberroside A
TMA1409
cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.
Viscidulin II
TN5238
Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β produ...
Isokaempferide
TN4303
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by red...
Arteannuin N
TN3453
Arteannuin N has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
5-Hydroxy-7,8-dimethoxyflavanone
TN3119
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
5,7-Dimethoxyflavanone
TN1232
5,7-Dimethoxyflavanone has anti-inflammatory activity.
Isorhamnetin 3-O-galactoside
TN1793
Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
N-Decyl-4-methoxyaniline
TN4561
Methylnissolin is a natural product from A. membranaceus.
Manassantin A
TN4489
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
9-O-Feruloyl-5,5'-dimethoxylariciresinol
TN3325
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cyt...
Cyclocurcumin
TN3741
Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rh...
cRIPGBM
T19250
cRIPGBM, a proapoptotic derivative of RIPGBM, selectively induces apoptosis in GBM cancer stem cells (CSCs) by targeting receptor-interacting protein kinase 2 (R...
Braylin
TN3537
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition ...
Desoxo-narchinol A
TN3839
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
Hyuganin D
TN4243
Hyuganin D can inhibit LPS-induced NO and/or TNF-alpha production in mouse peritoneal macrophages.
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TargetMol