Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research

Cat. No.	Product name	CAS No.	Purity
T65086	Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride	2746-19-2	99.32%
T65086	Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride may cause sensitization. Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride promotes apoptosis in HepG2 (IC50= 62 μM...
T3804	Neomangiferin	64809-67-2	99.32%
T3804	Neomangiferin (Mangiferin 7-glucoside) has beneficial effects on high fat diet-induced nonalcoholic fatty liver disease in rats. Neomangiferin and mangiferin inh...
T2P2923	Stearic acid	57-11-4	99.31%
T2P2923	1. Stearic acid (Cetylacetic acid) can reduce metastatic tumor burden. 2. Stearic acid leads to dramatically reduced visceral fat likely by causing the apoptosis...
T6521	GSK 2830371	1404456-53-6	99.3%
T6521	GSK 2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.
TCS1372	Atraric acid	4707-47-5	99.27%
TCS1372	Atraric acid derivatives as a new chemical lead structure for novel therapeutic compounds as AR antagonists, that can be used for prophylaxis or treatment of pro...
T8478	SC-43	1400989-25-4	99.26%
T8478	SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and ...
T20879	Tacrolimus monohydrate	109581-93-3	99.2%
T20879	Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form ...
T12901	SHIP2-IN-1	2252247-80-4	99.16%
T12901	SHIP2-IN-1 is a potent SHIP2 inhibitor(IC50 : 2 µM),and used in the research of Alzheimer’s disease.
T14327	AS1949490	1203680-76-5	99.16%
T14327	AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2]. AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing in...
T11955	MB-07729	882755-95-5	99.14%
T11955	MB-07729 is a potent non-competitive inhibitor of fructose-1,6-bisphosphate with IC50 values of 189, 121 and 31 nM in rat, monkey and human, respectively, for th...
T81417	PP5-IN-1	1022417-69-1	99.13%
T81417	PP5-IN-1 is a potent and competitive serine/threonine protein phosphatase-5 (PP5) inhibitor with potential anticancer activity that induces apoptosis in cancer c...
T9156	CDC25B-IN-2	134271-74-2	99.12%
T9156	BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.
T4852	Trimyristin	555-45-3	99.11%
T4852	Trimyristin (Tritetradecanoin) is primarily located in the membrane (predicted from logP) and adiposome. glyceryl trimyristate exists in all eukaryotes, ranging ...
T22276	Bis(maltolato)oxovanadium(IV)	38213-69-3	99.10%
T22276	Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicki...
T7084	2-Bromo-4'-hydroxyacetophenone	2491-38-5	99.07%
T7084	2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of ...
T61268	Vutiglabridin	1800188-47-9	98.90%
T61268	Vutiglabridin (HSG4112) is a novel and safe modulator of PON2, a racemic compound. vutiglabridin is an optimized structural analogue of Glabridin and is superior...
T6353	(-)-p-Bromotetramisole Oxalate	62284-79-1	98.89%
T6353	(-)-p-Bromotetramisole Oxalate (6-Bromolevamisole oxalate) is a potent and non-specific inhibitor of alkaline phosphatase.
T9196	IACS-13909	2160546-07-4	98.83%
T9196	IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.
T16009L	Managlinat dialanetil	280782-97-0	98.82%
T16009L	Managlinat dialanetil (MB06322) is an orally available and potent fructose 1,6-bisphosphatase (FBPase) inhibitor with hypoglycaemic activity for the study of typ...
T28506	Rbin-2	2032282-97-4	98.75%
T28506	Rbin-2 is a cell-permeable, potent, selective and reversible inhibitor of Midasin (Mdn1).Rbin-2 directly targets the AAA+ ATPase Midasin and inhibits eukaryotic ...