PKC

Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.

Cat. No.	Product name	CAS No.	Purity
T2356	Ro-3306	872573-93-8
T2356	RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
T1606	Fasudil	103745-39-7
T1606	Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T3060	Fasudil hydrochloride	105628-07-7
T3060	Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T8681	HA-1004 dihydrochloride	92564-34-6
T8681	HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
T2757	Myricitrin	17912-87-7	98%
T2757	Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.
T5817	PKC-theta inhibitor hcl	2253640-49-0	98%
T5817	PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).
T6513	Bisindolylmaleimide I	133052-90-1	98%
T6513	Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.
T5771	Hypocrellin A	77029-83-5	98%
T5771	Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted presen...
T6588	Mitoxantrone	65271-80-9	98%
T6588	Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA rep...
T14943	CGP60474	164658-13-3	98%
T14943	CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits ...
T35407	Ζ-Stat	3316-02-7	98%
T35407	ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and...
T77332	TV 3279	209394-29-6	98%
T77332	TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SO...
T22464	1,2-Dimyristoyl-sn-glycerol	60562-16-5	98%
T22464	1,2-Dimyristoyl-sn-glycerol (1,2-DMG) is able to increase AChE activity by 35-40% at concentrations of 25 micrograms/ml in the parasite S. mansoni..
T17019	TCS 21311	1260181-14-3	98%
T17019	TCS 21311 is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively)....
T60109	Protein kinase inhibitor H-7	84477-87-2	98%
T60109	Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependen...
TP1887L1	[Ala107]-MBP (104-118) acetate	TP1887L1	98%
TP1887L1	[Ala107]-MBP (104-118) acetate is synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).
T4444	A-674563 HCl (552325-73-2(free base))		98%
T4444	A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
T11665	Ionomycin calcium	56092-82-1	98%
T11665	lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase ...
TP1888L1	[Ala113]-MBP (104-118) acetate	TP1888L1	98%
TP1888L1	[Ala113]MBP(104-118) acetate is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC50s ranging from 28-62 μM.
T13363	Y06137	2226534-49-0	98%
T13363	Y06137 is an effective and selective BET inhibitor with a Kd of 81 nM for BRD4(1) bromodomain. Y06137 can be used for research on the treatment of castration-res...