Nrf2

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

Cat. No.	Product name	CAS No.	Purity
T10733	CDDO-EA	932730-51-3	98%
T10733	CDDO-EA is an activator of the Nrf2/antioxidant response element.
T6919	Omaveloxolone	1474034-05-3	98%
T6919	Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
T13604	CDDO-dhTFEA	1191265-33-4	98%
T13604	CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restores...
T6S1302	Carnosol	5957-80-2	98%
T6S1302	Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Carnosol enhances the sensitivity of chemoresistant cancer c...
T6165	Bardoxolone Methyl	218600-53-4	98%
T6165	Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
T3743	4-hydroxyphenylacetic acid	156-38-7	98%
T3743	4-hydroxyphenylacetic acid is a major microbiota-derived metabolite of polyphenols. 4-hydroxyphenylacetic acid is involved in the antioxidative action. 4-hydroxy...
T0973	Pyridoxine	65-23-6	98%
T0973	Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently us...
T2915	Bardoxolone	218600-44-3	98%
T2915	CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macr...
TN6750	2-tert-Butyl-1,4-benzoquinone	3602-55-9	98%
TN6750	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its ne...
T16331	NK-252	1414963-82-8	98%
T16331	NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.
TN4234	Hydrangenol	480-47-7	98%
TN4234	Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can...
TN1621	Eriodictyol-7-O-glucoside	38965-51-4	98%
TN1621	Eriodictyol-7-O-glucoside is an Nrf2 activator conferring protection against Cisplatin-induced toxicity. Eriodictyol-7-O-glucoside is a flavonoid and a free radi...
T0153	Oltipraz	64224-21-1	98%
T0153	Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
T12253	Nrf2-IN-1	1610022-76-8	98%
T12253	Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
T8704	4-hydroxyphenyl acetate	3233-32-7	98%
T8704	4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer
T5S1805	5,7-Dihydroxychromone	31721-94-5	98%
T5S1805	1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
T3227	Danshensu	76822-21-4	98%
T3227	Danshensu is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.
T60487	DDO-7263	2254004-96-9	98%
T60487	DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of...
T2794	Astilbin	29838-67-3	98%
T2794	Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
T3717	Hinokitiol	499-44-5	98%
T3717	β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity ...