Home Tools
Log in
Cart

Nrf2

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.
Cat. No. Product name CAS No. Purity Chemical Structure
T10733 CDDO-EA 932730-51-3 98%
CDDO-EA is an activator of the Nrf2/antioxidant response element.
T6919 Omaveloxolone 1474034-05-3 98%
Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
T13604 CDDO-dhTFEA 1191265-33-4 98%
CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restores...
T6S1302 Carnosol 5957-80-2 98%
Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Carnosol enhances the sensitivity of chemoresistant cancer c...
T6165 Bardoxolone Methyl 218600-53-4 98%
Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
T3743 4-hydroxyphenylacetic acid 156-38-7 98%
4-hydroxyphenylacetic acid is a major microbiota-derived metabolite of polyphenols. 4-hydroxyphenylacetic acid is involved in the antioxidative action. 4-hydroxy...
T0973 Pyridoxine 65-23-6 98%
Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently us...
T2915 Bardoxolone 218600-44-3 98%
CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macr...
TN6750 2-tert-Butyl-1,4-benzoquinone 3602-55-9 98%
2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its ne...
T16331 NK-252 1414963-82-8 98%
NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.
TN4234 Hydrangenol 480-47-7 98%
Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can...
TN1621 Eriodictyol-7-O-glucoside 38965-51-4 98%
Eriodictyol-7-O-glucoside is an Nrf2 activator conferring protection against Cisplatin-induced toxicity. Eriodictyol-7-O-glucoside is a flavonoid and a free radi...
T0153 Oltipraz 64224-21-1 98%
Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
T12253 Nrf2-IN-1 1610022-76-8 98%
Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
T8704 4-hydroxyphenyl acetate 3233-32-7 98%
4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer
T5S1805 5,7-Dihydroxychromone 31721-94-5 98%
1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
T3227 Danshensu 76822-21-4 98%
Danshensu is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.
T60487 DDO-7263 2254004-96-9 98%
DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of...
T2794 Astilbin 29838-67-3 98%
Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
T3717 Hinokitiol 499-44-5 98%
β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity ...
CDDO-EA
T10733
CDDO-EA is an activator of the Nrf2/antioxidant response element.
Omaveloxolone
T6919
Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
CDDO-dhTFEA
T13604
CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restores...
Carnosol
T6S1302
Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Carnosol enhances the sensitivity of chemoresistant cancer c...
Bardoxolone Methyl
T6165
Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
4-hydroxyphenylacetic acid
T3743
4-hydroxyphenylacetic acid is a major microbiota-derived metabolite of polyphenols. 4-hydroxyphenylacetic acid is involved in the antioxidative action. 4-hydroxy...
Pyridoxine
T0973
Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently us...
Bardoxolone
T2915
CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macr...
2-tert-Butyl-1,4-benzoquinone
TN6750
2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its ne...
NK-252
T16331
NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.
Hydrangenol
TN4234
Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can...
Eriodictyol-7-O-glucoside
TN1621
Eriodictyol-7-O-glucoside is an Nrf2 activator conferring protection against Cisplatin-induced toxicity. Eriodictyol-7-O-glucoside is a flavonoid and a free radi...
Oltipraz
T0153
Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
Nrf2-IN-1
T12253
Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
4-hydroxyphenyl acetate
T8704
4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer
5,7-Dihydroxychromone
T5S1805
1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
Danshensu
T3227
Danshensu is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.
DDO-7263
T60487
DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of...
Astilbin
T2794
Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
Hinokitiol
T3717
β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity ...
1 2 3 4