Nrf2

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

Cat. No.	Product name	CAS No.	Purity
TN6750	2-tert-Butyl-1,4-benzoquinone	3602-55-9	99.29%
TN6750	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its ne...
T0973	Pyridoxine	65-23-6	99.18%
T0973	Pyridoxine (Vitamin B6) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still ...
T3743	4-hydroxyphenylacetic acid	156-38-7	99.1%
T3743	4-hydroxyphenylacetic acid (parahydroxy phenylacetate) is a major microbiota-derived metabolite of polyphenols. 4-hydroxyphenylacetic acid(p-Hydroxyphenylacetic ...
T1516	Curcumin	458-37-7	98.98%
T1516	Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide...
TN5770	Gingerenone A	128700-97-0	98.94%
TN5770	Gingerenone A is an effective Nrf2-Gpx4 activator. It is a small molecule compound isolated from ginger. It has anti-cancer activity, can prolong the cell cycle ...
T6165	Bardoxolone Methyl	218600-53-4	98.94%
T6165	Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-t...
T6S0232	Eriodictyol	552-58-9	98.93%
T6S0232	1. Eriodictyol (Huazhongilexone) is a flavonoid with anti-inflammatory and antioxidant activities. 2. Eriodictyol may possess antidiabetic properties through inc...
T13604	CDDO-dhTFEA	1191265-33-4	98.88%
T13604	CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean art...
T6919	Omaveloxolone	1474034-05-3	98.7%
T6919	Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
T6S1302	Carnosol	5957-80-2	98.67%
T6S1302	Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be ...
T10733	CDDO-EA	932730-51-3	98.54%
T10733	CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.
T63016	Nrf2 activator-4	2383016-68-8	98.53%
T63016	Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated wi...
T11758L	KI696	1799974-70-1	98.42%
T11758L	KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.
TN2063	Physalin B	23133-56-4	98.40%
TN2063	Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammat...
T3227	Danshensu	76822-21-4	98.4%
T3227	Danshensu (Dan shen suan A) is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.
T28497	RA-839	1832713-02-6	98.38%
T28497	RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer acti...
TQ0120	CDDO-Im	443104-02-7	98.3%
TQ0120	CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
T6S2356	Corynoline	18797-79-0	98.29%
T6S2356	1. Corynoline ((+)-Corynoline) is an acetylcholinesterase inhibitor.
TN1461	(-)-Butin	492-14-8	98.07%
TN1461	(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it at...
TN2166	Rupestonic acid	115473-63-7	98.07%
TN2166	Rupestonic acid is a compound in Artemisia rupestris L., a well-known traditional Uighur medicine for the treatment of colds. Rupestonic acid has an anti-influen...