NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T5668	Triacetylresveratrol	42206-94-0	98%
T5668	Acetyl-trans-resveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancr...
T5769	Stachydrine	471-87-4	98%
T5769	Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibi...
T5773	Moslosooflavone	3570-62-5	98%
T5773	5-hydroxy-7,8-dimethoxyflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone signific...
T4126	CBL0137	1197996-80-7	98%
T4126	CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin ...
T5558	Chelidonic acid	99-32-1	98%
T5558	Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also sho...
T4S0878	Prunetin	552-59-0	98%
T4S0878	1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obes...
T5814	Aurantiamide	58115-31-4	98%
T5814	Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Auran...
T5S1891	Flaconitine	77181-26-1	98%
T5S1891	Analgesic activity.
T3406	Kuromanin chloride	7084-24-4	98%
T3406	Cyanidin-3-O-glucoside chloride is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.
T2P2870	Damascenone	23696-85-7	98%
T2P2870	Damascenone is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.
T17217	Vamorolone	13209-41-1	98%
T17217	Vamorolone is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects...
TWS1977	Kamebakaurin	73981-34-7	98%
TWS1977	1. Kamebakaurin has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stre...
T10809L	CHPG hydrochloride	T10809L	98%
T10809L	CHPG hydrochloride is a selective agonist of mGluR5.
T11096	DRI-C21045	2101765-81-3	98%
T11096	Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.D...
T2755	Rhoifolin	17306-46-6	98%
T2755	Rhoifolin is extracted from Turpinia arguya Seem dried leaves.
T3S0335	Soyasaponin Bb	51330-27-9	98%
T3S0335	1. Soyasaponin Bb can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kapp...
T9582	CLEFMA	1246964-32-8	98%
T9582	CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
T125120	Cyclo(L-Pro-L-Val)	2854-40-2	98%
T125120	Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory act...
T15204	EHT 1610	1425945-60-3	98%
T15204	EHT 1610 is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on leukemia, r...
T3012	Mangiferin	4773-96-0	98%
T3012	Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.