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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Cat. No. Product name CAS No. Purity Chemical Structure
T5668 Triacetylresveratrol 42206-94-0 98%
Acetyl-trans-resveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancr...
T5769 Stachydrine 471-87-4 98%
Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibi...
T5773 Moslosooflavone 3570-62-5 98%
5-hydroxy-7,8-dimethoxyflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone signific...
T4126 CBL0137 1197996-80-7 98%
CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin ...
T5558 Chelidonic acid 99-32-1 98%
Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also sho...
T4S0878 Prunetin 552-59-0 98%
1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obes...
T5814 Aurantiamide 58115-31-4 98%
Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Auran...
T5S1891 Flaconitine 77181-26-1 98%
Analgesic activity.
T3406 Kuromanin chloride 7084-24-4 98%
Cyanidin-3-O-glucoside chloride is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.
T2P2870 Damascenone 23696-85-7 98%
Damascenone is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.
T17217 Vamorolone 13209-41-1 98%
Vamorolone is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects...
TWS1977 Kamebakaurin 73981-34-7 98%
1. Kamebakaurin has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stre...
T10809L CHPG hydrochloride T10809L 98%
CHPG hydrochloride is a selective agonist of mGluR5.
T11096 DRI-C21045 2101765-81-3 98%
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.D...
T2755 Rhoifolin 17306-46-6 98%
Rhoifolin is extracted from Turpinia arguya Seem dried leaves.
T3S0335 Soyasaponin Bb 51330-27-9 98%
1. Soyasaponin Bb can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kapp...
T9582 CLEFMA 1246964-32-8 98%
CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
T125120 Cyclo(L-Pro-L-Val) 2854-40-2 98%
Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory act...
T15204 EHT 1610 1425945-60-3 98%
EHT 1610 is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on leukemia, r...
T3012 Mangiferin 4773-96-0 98%
Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.
Triacetylresveratrol
T5668
Acetyl-trans-resveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancr...
Stachydrine
T5769
Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibi...
Moslosooflavone
T5773
5-hydroxy-7,8-dimethoxyflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone signific...
CBL0137
T4126
CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin ...
Chelidonic acid
T5558
Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also sho...
Prunetin
T4S0878
1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obes...
Aurantiamide
T5814
Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Auran...
Flaconitine
T5S1891
Analgesic activity.
Kuromanin chloride
T3406
Cyanidin-3-O-glucoside chloride is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.
Damascenone
T2P2870
Damascenone is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.
Vamorolone
T17217
Vamorolone is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects...
Kamebakaurin
TWS1977
1. Kamebakaurin has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stre...
CHPG hydrochloride
T10809L
CHPG hydrochloride is a selective agonist of mGluR5.
DRI-C21045
T11096
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.D...
Rhoifolin
T2755
Rhoifolin is extracted from Turpinia arguya Seem dried leaves.
Soyasaponin Bb
T3S0335
1. Soyasaponin Bb can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kapp...
CLEFMA
T9582
CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
Cyclo(L-Pro-L-Val)
T125120
Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory act...
EHT 1610
T15204
EHT 1610 is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on leukemia, r...
Mangiferin
T3012
Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.
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