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Cat No. | Product Name | Synonyms | Targets |
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T6891 | MK-4101 | Apoptosis , Hedgehog/Smoothened , Smo | |
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells. | |||
T9531 | MRT-14 | Smo | |
MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies. | |||
T2450 | SANT-1 | SANT 1 | Hedgehog/Smoothened , Smo |
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM). | |||
T22814 | GSA-10 | Hedgehog/Smoothened | |
Smoothened (Smo) receptor agonist | |||
T15019 | CUR61414 | Hedgehog/Smoothened | |
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM). | |||
T2666 | Taladegib | LY2940680 | Hedgehog/Smoothened , Smo |
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. | |||
T1779 | SAG | Smoothened Agonist (SAG) HCl,Smoothened Agonist | Hedgehog/Smoothened , Smo |
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway. | |||
T1926 | Sonidegib | Erismodegib,NVP-LDE225,LDE225 | Hedgehog/Smoothened , Smo |
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. | |||
T9532 | MRT-81 | Others | |
MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cance... | |||
T63429 | SMO-IN-2 | Hedgehog/Smoothened | |
SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of c... | |||
T40465 | SAG dihydrochloride | Hedgehog/Smoothened | |
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo. | |||
T64351 | GI-560192 | RL-0070933 | Smo |
GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway. | |||
T15019L | CUR61414 hydrochloride | CUR61414 hydrochloride (334998-36-6 Free base) | Hedgehog/Smoothened |
CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively... | |||
T23027 | MRT-10 | Hedgehog/Smoothened | |
MRT-10 is a Smoothened (Smo) receptor antagonist. | |||
T24754 | Hh-Ag1.5 | SAG-1.5,SAG1.5,SAG 1.5 | Hedgehog/Smoothened |
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies... | |||
T71299 | M-25 | ||
M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway. | |||
T16843 | Saridegib | IPI-926,Patidegib | Others |
Saridegib is an effective and specific inhibitor of Smoothened and a key signaling transmembrane protein in the Hedgehog pathway. | |||
T23307 | SANT 2 | SANT-2 | Others |
SANT-2 is an inhibitor of Sonic hedgehog signaling and also antagonizes smoothened receptor activity (KD = 12 nM). | |||
T25918 | Palmitoyl-L-aspartic acid | L-N-Palmitoylaspartic acid | |
Palmitoyl-L-aspartic acid is a natural N-acylaspartate that suppresses Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. It does not alter the activity of cannabinoid rec... | |||
T71520 | LEQ-506 | ||
LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand ce... | |||
T63387 | SMO-IN-3 | ||
SMO-IN-3 is a potent inhibitor of smoothened (SMO) that acts on the hedgehog (Hh) signaling pathway (IC50: 34.09 nM). SMO-IN-3 inhibits the proliferation of Daoy, a human medulloblastoma cell line, and exhibits anticance... | |||
T38767 | MRT-83 hydrochloride | ||
MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor, effectively inhibiting the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. With its potential applications in t... | |||
T62772 | TPB15 | ||
TPB15 is an orally active inhibitor of Hh (Hedgehog) signalling. TPB15 significantly blocks the MDA-MB-468 cell cycle and induces apoptosis. TPB15 blocks Smo (Smoothened) translocation into cilia and reduces Smo protein ... | |||
T35537 | Hedgehog Antagonist VIII | ||
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcript... | |||
T35538 | HPI-1 (hydrate) | HPI-1 hydrate | |
HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss o... | |||
T35539 | IHR-Cy3 | IHR-Cy3 | |
Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog also available. Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Ch... | |||
T70195 | NL-103 | ||
NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibito... | |||
T35562 | Nat-20(S)-yne | ||
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which bin... | |||
T35558 | KAAD-Cyclopamine | ||
Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyc... | |||
T36910 | PF 04449913 maleate | ||
Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells. Munchhof et al (2011) Discov... |
Cat No. | Product Name | Synonyms | Targets |
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T2825 | Cyclopamine | 11-Deoxojervine | Hedgehog/Smoothened , Endogenous Metabolite , Smo |
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids. | |||
T3363 | Jervine | Iervin,11-Ketocyclopamine,Jerwiny | Hedgehog/Smoothened , Smo |
The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signa... | |||
T3912 | Saikosaponin B1 | Others | |
Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro. |
Cat No. | Product Name | Species | Expression System |
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TMPY-03345 | Sonic Hedgehog Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha... | |||
TMPY-02832 | SHH Protein, Human, Recombinant (aa 198-462, His) | Human | HEK293 |
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha... | |||
TMPY-02905 | SHH Protein, Human, Recombinant (aa 1-197, His) | Human | HEK293 |
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha... | |||
TMPJ-01127 | SHH Protein, Human, Recombinant | Human | E. coli |
Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic... | |||
TMPJ-01128 | SHH Protein, Human, Recombinant (C24II) | Human | E. coli |
Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called Hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic... | |||
TMPH-02540 | GRK2 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to... |