Cart
GPCR/G Protein Hedgehog/Smoothened

Hedgehog/Smoothened

The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.Smoothened is a protein that in humans is encoded by the SMO gene. Smoothened is a Class Frizzled (Class F) G protein-coupled receptor that is a component of the hedgehog signaling pathway and is conserved from flies to humans. It is the molecular target of the natural teratogen cyclopamine. It also is the target of Vismodegib, the first hedgehog pathway inhibitor to be approved by the U.S. Food and Drug Administration (FDA).
Cat No. product name
T2590 VismodegibHOT Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
T2825 CyclopamineHOT Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
T15370 GANT 58 GANT 58 is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).
T3363 Jervine The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened...
T6514 Glasdegib Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
T2666 Taladegib Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic ac...
T1094 Tolnaftate Tolnaftate is a synthetic antifungal agent.
T3156 Ciliobrevin A Ciliobrevin A is a hedgehog (Hh) signaling pathway inhibitor with IC50 less than 10 μM.
T2450 SANT1 SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
T3588 JK184 JK184 is a potent Hedgehog (Hh) pathway inhibitor.
T1810 Purmorphamine Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
T0465 Ellagic acid Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T14188 ALLO-2 ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
T3460 HhAntag HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
T3070 GANT61 GANT 61 is an inhibitor for Gli1 and Gli2.
T1543 Naftifine hydrochloride Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact...
T1779 Smoothened Agonist SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
T6891 MK4101 MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
T1926 NVP-LDE225 LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
T4211 SAG hydrochloride (912545-86-9(free base)) SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.
T2299 BMS833923 BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
Vismodegib HOT
T2590CAS 879085-55-9
Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
Cyclopamine HOT
T2825CAS 4449-51-8
Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
GANT 58
T15370CAS 64048-12-0
GANT 58 is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).
Jervine
T3363CAS 469-59-0
The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened...
Glasdegib
T6514CAS 1095173-27-5
Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
Taladegib
T2666CAS 1258861-20-9
Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic ac...
Tolnaftate
T1094CAS 2398-96-1
Tolnaftate is a synthetic antifungal agent.
Ciliobrevin A
T3156CAS 302803-72-1
Ciliobrevin A is a hedgehog (Hh) signaling pathway inhibitor with IC50 less than 10 μM.
SANT1
T2450CAS 304909-07-7
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
JK184
T3588CAS 315703-52-7
JK184 is a potent Hedgehog (Hh) pathway inhibitor.
Purmorphamine
T1810CAS 483367-10-8
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
Ellagic acid
T0465CAS 476-66-4
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
ALLO-2
T14188CAS 1357350-60-7
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
HhAntag
T3460CAS 496794-70-8
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
GANT61
T3070CAS 500579-04-4
GANT 61 is an inhibitor for Gli1 and Gli2.
Naftifine hydrochloride
T1543CAS 65473-14-5
Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact...
Smoothened Agonist
T1779CAS 912545-86-9
SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
MK4101
T6891CAS 935273-79-3
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
NVP-LDE225
T1926CAS 956697-53-3
LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
SAG hydrochloride (912545-86-9(free base))
T4211CAS T4211
SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.
BMS833923
T2299CAS 1059734-66-5
BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).