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Hedgehog/Smoothened

T0465 Ellagic acid Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
T1094 Tolnaftate Tolnaftate is a synthetic antifungal agent.
T1543 Naftifine hydrochloride Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exac...
T1810 Purmorphamine Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
T1926 Sonidegib LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
T2299 BMS-833923 BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
T2450 SANT-1 SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
T2590 Vismodegib Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
T2666 Taladegib Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic a...
T2825 Cyclopamine Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
T3070 GANT61 GANT 61 is an inhibitor for Gli1 and Gli2.
T3156 Ciliobrevin A Ciliobrevin A is a hedgehog (Hh) signaling pathway inhibitor with IC50 less than 10 μM.
T3363 Jervine The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothen...
T3460 HhAntag HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity...
T3588 JK184 JK184 is a potent Hedgehog (Hh) pathway inhibitor.
T4211 SAG hydrochloride (912545-86-9(free base)) SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.
T6891 MK-4101 MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in...
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