Home Tools
Log in
Cart

Endothelin Receptor

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T15596 IRL 2500 169545-27-1 98.29%
IRL 2500
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
T6672 Sitaxsentan sodium 210421-74-2 98%
Sitaxsentan sodium
Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.
T6792 BQ-123 136553-81-6 98%
BQ-123
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
T12924 Sitaxsentan 184036-34-8 97.99%
Sitaxsentan
Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endo...
T31640 Enrasentan 167256-08-8 97.96%
Enrasentan
Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure, prevents cardiac hypertrophy, and protects myocardial func...
T5458 Darusentan 171714-84-4 97.26%
Darusentan
Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries
T15595L IRL-1620 acetate T15595L 96.64%
IRL-1620 acetate
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
T14219 Aminaftone 14748-94-8 96.31%
Aminaftone
Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.
T6264 Bosentan 147536-97-8 100%
Bosentan
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endotheli...
T19309L1 Endothelin 1 (swine, human) acetate T19309L1
Endothelin 1 (swine, human) acetate
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
T21790 BMS 182874 hydrochloride 1215703-04-0
BMS 182874 hydrochloride
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
T10595 BQ-788 173326-37-9 98%
BQ-788
BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenou...
TQ0259 Atrasentan 173937-91-2 98%
Atrasentan
Atrasentan (ABT-627) (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
TP1220L Carperitide acetate 1366000-58-9 98%
Carperitide acetate
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate), a 28-amino acid hormone, is naturally produced and released by the human h...
IRL 2500
T15596
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
Sitaxsentan sodium
T6672
Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.
BQ-123
T6792
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
Sitaxsentan
T12924
Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endo...
Enrasentan
T31640
Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure, prevents cardiac hypertrophy, and protects myocardial func...
Darusentan
T5458
Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries
IRL-1620 acetate
T15595L
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
Aminaftone
T14219
Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.
Bosentan
T6264
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endotheli...
Endothelin 1 (swine, human) acetate
T19309L1
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
BMS 182874 hydrochloride
T21790
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
BQ-788
T10595
BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenou...
Atrasentan
TQ0259
Atrasentan (ABT-627) (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
Carperitide acetate
TP1220L
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate), a 28-amino acid hormone, is naturally produced and released by the human h...
1 2
TargetMol