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DNA gyrase

DNA gyrase is an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA. Gyrase belongs to a class of enzymes known as topoisomerases that are involved in the control of topological transitions of DNA.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T13231 Trovafloxacin 147059-72-1 99.27%
Trovafloxacin
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
T1095 Sparfloxacin 110871-86-8 99.95%
Sparfloxacin
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
T7786 Tryptanthrin 13220-57-0 99.94%
Tryptanthrin
Tryptanthrin is a natural DNA gyrase inhibitor.
T0717 Enoxacin hydrate 84294-96-2 99.86%
Enoxacin hydrate
Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
T0116 Balofloxacin 127294-70-6 99.84%
Balofloxacin
Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.
T67826 Alalevonadifloxacin 2892364-59-7 99.63%
Alalevonadifloxacin
Alalevonadifloxacin is a DNA gyrase and DNA topoisomerase inhibitor and a novel antibacterial compound of the quinolone class targeting MRSa. Alalevonadifloxacin...
TQ0063 Zoliflodacin 1620458-09-4 99.51%
Zoliflodacin
Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against ...
T0250 Ciprofloxacin monohydrochloride 93107-08-5 99.5%
Ciprofloxacin monohydrochloride
Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.
T1294 Fleroxacin 79660-72-3 99.34%
Fleroxacin
Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
T2353 BRD7116 329059-55-4 99.3%
BRD7116
BRD7116 competitively binds to bacterial DNA gyrase, with cell-non-autonomous anti-leukemia activity.
T0974 Novobiocin Sodium 1476-53-5 99%
Novobiocin Sodium
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derive...
T20510 Novobiocin 303-81-1 98.72%
Novobiocin
Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on...
T1306 Norfloxacin 70458-96-7 100%
Norfloxacin
Norfloxacin (MK-0366)(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
T8747 Levofloxacin hydrochloride 177325-13-2
Levofloxacin hydrochloride
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxac...
T1492 Gemifloxacin mesylate 210353-53-0 98%
Gemifloxacin mesylate
Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial...
T1451 Levofloxacin hydrate 138199-71-0 98%
Levofloxacin hydrate
Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacter...
Trovafloxacin
T13231
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
Sparfloxacin
T1095
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
Tryptanthrin
T7786
Tryptanthrin is a natural DNA gyrase inhibitor.
Enoxacin hydrate
T0717
Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
Balofloxacin
T0116
Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.
Alalevonadifloxacin
T67826
Alalevonadifloxacin is a DNA gyrase and DNA topoisomerase inhibitor and a novel antibacterial compound of the quinolone class targeting MRSa. Alalevonadifloxacin...
Zoliflodacin
TQ0063
Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against ...
Ciprofloxacin monohydrochloride
T0250
Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.
Fleroxacin
T1294
Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
BRD7116
T2353
BRD7116 competitively binds to bacterial DNA gyrase, with cell-non-autonomous anti-leukemia activity.
Novobiocin Sodium
T0974
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derive...
Novobiocin
T20510
Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on...
Norfloxacin
T1306
Norfloxacin (MK-0366)(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Levofloxacin hydrochloride
T8747
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxac...
Gemifloxacin mesylate
T1492
Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial...
Levofloxacin hydrate
T1451
Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacter...
TargetMol