v-11-0711

V-11-0711 is an inhibitor of Chk-α, which may be essential in cancer cell proliferation.

V-11-0711 HCl is a selective and highly effective choline kinase α (ChoKα) inhibitor that inhibits the catalytic activity of Chk.

V-11-0711 (hydrochloride) is a potent and selective Chk-α inhibitor with an IC50 of 20 nM. This compound significantly reduces PCho levels and can cause reversible growth arrest. At high concentrations, V-11-0711 (hydrochloride) induces apoptosis. It is applicable in research on cervical cancer and triple-negative breast cancer.

cis-V-11-0711 is the cis form of V-11-0711, a potent and selective inhibitor of Chk-α with an IC50 of 20 nM. V-11-0711 significantly reduces PCho levels and can cause reversible growth arrest. At high concentrations, V-11-0711 induces apoptosis and is applicable in research on cervical cancer and triple-negative breast cancer.