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(2)
By Target- p38 MAPK
- Carbonic Anhydrase(1)
- MAPK(1)
- TNF(1)
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Results for "
u104
" in TargetMol Product Catalog- Inhibitors & Agonists3
- Isotope Products1
(R)-STU104-d6
T2074253063042-81-6
(R)-STU104-d6 is a deuterium-labeled variant of (R)-STU104. This compound acts as a potent and orally active inhibitor of the interaction between TAK1 and MKK3 proteins, exhibiting IC50 values of 0.58 μM for TNF-α and 4.0 μM for MKK3 phosphorylation. By binding to MKK3, (R)-STU104 hinders TAK1's ability to phosphorylate MKK3, thereby disrupting the TAK1/MKK3/p38/MnK1/MK2/elF4E signaling pathway. It is utilized in research related to ulcerative colitis.
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