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Results for "

tyk2 jh2

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    11
    TargetMol | Inhibitors_Agonists
  • Isotope Products
    3
    TargetMol | Isotope_Products
Deucravacitinib
BMS-986165
T146871609392-27-9
Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor for the treatment of autoimmune diseases. It blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain, inhibiting IL-12 23 and type I IFN pathways. It selectively binds to the TYK2 pseudokinase (JH2) domain with an IC50 of 1.0 nM.
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TargetMol | Inhibitor Hot
bms-986202
T702141771691-34-9
BMS-986202 is a novel Tyk2 inhibitor, binding to Tyk2 JH2, showing efficacies for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus.
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6-8 weeks
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Tyk2-IN-7
T132351609391-90-3
Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).
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6-8 weeks
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