tripterygium

Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.

Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signaling pathway, and it can significantly reduce atherosclerosis.

1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell characteristics and EMT in cancer cells. 2. Pristimerin down-regulates the expression of pro-inflammatory mediators through blocking of NF-κB activation by inhibiting interconnected ROS IKK NF-κB signaling pathways, can effectively inhibit both arthritic inflammation and cartilage and bone damage in the joints.

Wilforol A is a natural product from Tripterygium wilfordii Hook. f.

Triptonoterpene is a natural product found in Tripterygium wilfordii and Tripterygium doianum. Triptonoterpene is an abietane diterpenoid.

Triptotriterpenic acid A, a natural product isolated from *Tripterygium wilfordii*,

Regelin is an antitumor ursene-type triterpenoid isolated from Tripterygium regelii.

Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE co

Wilforlide A (3-Epiabruslactone A) is a natural product, separated from the ethanolic extract of tripterygium wilfordii. High-dose wilforlide A has obvious anti-inflammatory effect, but has no significant immune suppressive activity.

Triptophenolide (Hypolide) is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.

Peritassine A, an alkaloid derived from Tripterygium wilfordii Hook. f., exhibits anti-HIV properties.

Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis.

1. Wilforgine exhibits insecticidal activity of some degree.

1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1 2 and p38 MAPK inhibitors.

Wilforine, a sesquiterpene pyridine alkaloid, is an important bioactive compound in T. wilfordii plants and is effective in treating idiopathic pulmonary fibrosis. Wilforine exhibits an anti-inflammatory effect, which might be mediated by the down-regulation of inflammatory factors TNF-α, IL-6, and NO. Additionally, it has insecticidal activity by inhibiting the Na+-K+-ATPase in the central nervous system.

Triptotriterpenic acid C, an ursolic-type compound, can be isolated from the total glycosides extracted from the root of Tripterygium wilfordii Hook.f [1].

Triptoquinone H, a natural product derived from the traditional Chinese medicinal plant Tripterygium hypoglaucu, exhibits potent cytotoxic, immunomodulatory, and anti-inflammatory properties. It is utilized in research concerning cancer or inflammatory diseases [1].

Triptonoterpenol (Compound 6) is a secondary metabolite derived from Tripterygium wilfordii [1].

Triptonoterpene Me ether (compound 5), a rosinane-type diterpenoid, is derived from the traditional Chinese medicinal plant, Tripterygium wilfordii Hook. f [1].

Triptonoditerpenic acid is an aromatic pimarane diterpenoid that can be isolated from Tripterygium wilfordii. It exhibits cytotoxicity against HepG2, Hep3B, and Bcap37 cell lines, with IC50 values of 42.53 μM, 29.74 μM, and 37.63 μM, respectively.

1b-Benzoyl-8a-cinnamoyl-4a,5a-dihydroxydihydroagarofuran is a sesquiterpenoid isolated from the root bark of Tripterygium hypoglaucum, characterized by benzoyl and cinnamoyl groups [1].

Wilforlide A (T1) serves as a quality control standard of Tripterygium Glycosides that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. T1 has anti-inflammatory effects.

Triptobenzene H shows the significant immunosuppressive activity.

Euojaponine D is a natural product