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By Target- Calcium Channel
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Results for "
transned 19
" in TargetMol Product Catalog.- Inhibitors & Agonists1
trans-Ned 19
T12205L1354235-96-3
trans-Ned 19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist and two-pore channel (TPC) blocker. It binds with high affinity to the NAADP receptor to inhibit NAADP-dependent lysosomal/endolysosomal calcium release without affecting IP3 or cADPR-mediated calcium signaling pathways. Functionally, trans-Ned 19 inhibits glucose-induced calcium oscillations in pancreatic islets and low histamine concentration-induced endothelium-dependent vasodilation, and reduces Ebola virus infection of host cells. In immunomodulation, NAADP signaling blockade by trans-Ned 19 promotes the conversion of mouse Th17 cells to regulatory T cells (Tregs) and shows protective effects in intestinal inflammation models.
- $66
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QTY
T226701137264-00-6
nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist
- $1,520
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QTY
T12205874374-25-1
Ned 19, a selective membrane-permeant non-competitive antagonist of NAADP, strongly inhibits tumor growth, vascularization, and lung metastases in mice.
- $58
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