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By Target- AChR
- Caspase(1)
- Serine Protease(1)
- Others(1)
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- Recombinant Protein6
N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
TLCK hydrochloride
T2100154238-41-9
N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.
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