tps 1

TPS1-IN-1 (Compound O1) is a potent and broad-spectrum inhibitor of TPS1. It exhibits IC50 values of 14.73 μM for MoTPS1 (Magnaporthe oryzae TPS1) and 59.99 μM for BcTPS1 (Botrytis cinerea TPS1). TPS1-IN-1 exerts its broad-spectrum fungicidal effects by disrupting spore germination, appressorium formation, and turgor pressure accumulation in fungi. With good safety profiles, TPS1-IN-1 has potential as a candidate for novel fungicide development.

CTP Synthetase-IN-1 is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits human CTPS1 and human CTPS2, and can be used in studies of arthritis and rheumatoid arthritis.

CTP Synthetase-IN-1 Ammonium salt is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antimicrobial, anti-inflammatory and antitumor activity for the study of SARS-CoV-2 viral infections.

MoTPS1/2-IN-1 (Compound A1-4) is a dual-specificity inhibitor targeting MoTps1 and MoTps2. It demonstrates antifungal properties, effectively inhibiting the growth and virulence of both B. cinerea and F. graminearum.

DY428174 is a Novel potent Inhibitor of PI3Kalpha.

TP-S1-68 is a Type-I inhibitor of TIE-2.

MoTPS1-IN-1 is a potent MoTPS1 inhibitor with antifungal and potentially anti-inflammatory activity that acts through interaction with Glu396 and can be used to study ulcerative colitis.

CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.

Dencatistat is a highly selective and orally available cytidine triphosphate synthase 1 (CTPS1) inhibitor that specifically inhibits CTPS1 without affecting CTPS2.CTPS1-IN-2 reduces cancer cell proliferation for the treatment of B-cell, T-cell lymphomas and solid tumors.