tazobactam

Tazobactam (YTR-830H) is an antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.

Tazobactam sodium primarily functions to inhibit β-lactamase enzymes produced by bacteria.

Ceftolozane, also known as FR-264,205 and CXA-101; is an antibiotic drug from the cephalosporin family, approved for the treatment of infections with gram-negative bacteria, or gram-positive bacteria. Ceftolozane is of great benefit due to its ability to target bacteria that have become resistant to conventional antibiotics. Ceftolozane is combined with the β-lactamase inhibitor tazobactam, as multi-drug resistant bacterial infections will generally show resistance to all β-lactam antibiotics unless this enzyme is inhibited. .

Piperacillin mixture with tazobactam (8:1) is a combination antibiotic known as Piperacillin-Tazobactam, formulated at an 8:1 ratio. This β-lactam/β-lactamase inhibitor duo exhibits broad-spectrum antibacterial activity, effective against a wide range of Gram-positive, Gram-negative aerobic, and anaerobic bacteria, including many pathogens that produce β-lactamase.

Tazobactamimpurity 13 is a type of impurity associated with Tazobactam.

Tazobactam (Standard) is a reference standard for research and analysis in studies involving Tazobactam. Tazobactam (YTR-830H) is an antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.

Tazobactam-[13C2, 15N3] Sodium Salt (Standard) is a reference standard of Tazobactam-[13C2, 15N3] Sodium Salt intended for quantitative analysis, quality control, and related biochemical research applications.

Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide is a useful organic compound for research related to life sciences and the catalog number is T67423.

Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor used to treat multi-drug resistant gram-negative bacterial infections.

Enmetazobactam (iodide) (AAI101 (iodide)) serves as an extended-spectrum β-lactamase inhibitor effective against numerous resistant Gram-negative pathogens [1] [2].

Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic. It exhibits potent bactericidal activity against Gram-negative bacteria and some Gram-positive bacteria by targeting penicillin-binding proteins. Piperacillin hydrate is frequently combined with the β-lactamase inhibitor Tazobactam for enhanced efficacy.

Apalcillin (PC-904) combined with Ro 48-1220 (a penicillin sulfone β-lactamase inhibitor) exhibits broad-spectrum activity against Gram-negative aerobic and anaerobic bacteria, excluding Klebsiella acid-producing strains. This combination shows strong efficacy against β-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae with an effective MIC of 11 μg/mL. Additionally, it inhibits Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter at low MICs (0.25 to 4 μg/mL). However, it has limited efficacy against oxacillin-resistant staphylococci and some Gram-positive bacteria. Apalcillin/Ro 48-1220's effectiveness against certain extended-spectrum β-lactamase-producing Escherichia coli is comparable to piperacillin/tazobactam, though it is less effective against SHV-type β-lactamases.

Tachyplesin-3 is a broad-spectrum cationic antimicrobial peptide. It exhibits inhibitory activity against Gram-positive bacteria, Gram-negative bacteria, fungi, and enveloped viruses. Tachyplesin-3 disrupts membrane integrity by binding to bacterial membrane lipopolysaccharides through its positive charge, leading to leakage of cellular contents. It also interferes with bacterial adhesion and aggregation, preventing biofilm formation, and shows a synergistic effect when used in combination with Piperacillin-Tazobactam (TZP).