t-4

(T-4)-Copper(1+), bis[2,9-bis(4-methoxyphenyl)-1,10-phenanthroline-κN1,κN10]-, chloride is a reagent used in biochemical reactions.

4-Aminobutyl-DOTA-tris(t-butyl ester) is a bifunctional chelator (Bifunctional Chelator;BFC) and serves as a macrocyclic DOTA derivative for tumor pre-targeting. It is suitable for conjugating peptides and radionuclides.

Pent-4-enal is an organic compound containing a carbon-carbon double bond and an aldehyde group, which is commonly used in biochemical experiments and the preparation of fragrances, and can be used as an intermediate in organic synthesis for the preparation of other compounds.

Pent-4-en-1-yl Acetate is an ester compound widely used in biochemical experiments and drug synthesis research.

2,2-Dimethylpent-4-enoic acid is an organic acid containing a double bond and a carboxyl group, widely used in biochemical experiments and drug synthesis research.

Super-chelating agent& MRI contrast agent

Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lopez, J.A.V., Nogawa, T., Futamura, Y., et al.Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647J. Antibiot. (Tokyo)72(12)991-995(2019) 2.Ishida, S., Arai, M., Niikawa, H., et al.Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm formation of Mycobacterium speciesBiol. Pharm. Bull.34(6)917-920(2011) 3.Kalinovskaya, N.I., Romaneko, L.A., Irisawa, T., et al.Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activityMicrobiol. Res.166(8)654-661(2011) 4.Matsubara, K., Sakuda, S., Tanaka, M., et al.Morphological changes in insect BM-N4 cells induced by nocardamineBiosci. Biotechnol. Biochem.62(10)2049-2051(1998)

C14-4 (C14-494) is an ionizable lipid nanoparticle used for delivering CAR mRNA to primary human T cells.

L-Asparaginase (L-ASNase) (L-ASNase), a hydrolase that catalyzes the conversion of L-asparagine, used in acute lymphoblastic leukemia treatment.Asparaginase is an enzyme that is used as a medication. As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and non-Hodgkin's lymphoma. It is given by injection into a vein, muscle, or under the skin.

4-Hydroxynonenal/BSA is an antigen-adjuvant conjugate composed of 4-Hydroxynonenal and bovine serum albumin (BSA). This conjugation enhances the production of antigen-specific antibodies in vaccine models by coupling the antigen with a protein adjuvant. The conjugate maintains proper protein folding and does not disrupt major epitopes, while also improving cross-presentation and the generation of antigen-specific T cells.

1-(2-Aminoethyl)-1H-pyrazol-4-ylphosphonic acid/BSA is an antigen-adjuvant conjugate formed by linking 1-(2-Aminoethyl)-1H-pyrazol-4-ylphosphonic acid to bovine serum albumin (BSA). This conjugation amplifies antigen-specific antibody production in vaccine models without affecting protein folding or disrupting primary epitopes. Additionally, it enhances cross-presentation and the generation of antigen-specific T cells.

1-(2-Aminoethyl)-1H-pyrazol-4-ylphosphonic acid linker/BSA is an antigen-adjuvant conjugate consisting of 1-(2-Aminoethyl)-1H-pyrazol-4-ylphosphonic acid linker combined with bovine serum albumin (BSA). Conjugating the antigen with a protein adjuvant enhances the production of antigen-specific antibodies in vaccine models. The conjugate does not affect protein folding or disrupt primary epitopes, and it can improve cross-presentation and induce antigen-specific T cells.

1-(2-Aminoethyl)-1H-pyrazol-4-ylphosphonic acid-OVA is an antigen-adjuvant conjugate comprising 1-(2-Aminoethyl)-1H-pyrazol-4-ylphosphonic acid linked to ovalbumin (OVA). Conjugating the antigen with a protein adjuvant boosts the generation of antigen-specific antibodies in vaccine models. This conjugate maintains protein folding and preserves major epitopes, while also enhancing cross-presentation and the production of antigen-specific T cells.