swertia

Swertiamarin (Swertiamaroside) is a common secoiridoid found among the members of Gentianaceae with anti-inflammatory, anticancer, hypoglycemic and hypolipidemic activities.

1. Swertianolin (Bellidifolin-8-O-Glucoside), mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic markers to differentiate Gentianaceae species. 2. Swertianolin and swertiamarin show significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate. 3. Swertianolin shows anti-acetylcholinesterase activity effects. 4. Swertianolin shows that it can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton.

Swertiaside, a natural product isolated from Swertia mussotii Franch [1], is a chemical compound.

Swertiaperennin is a natural product

Swertiajaponin possesses antimicrobial activity.

Swertiachoside B is a useful organic compound for research related to life sciences. The catalog number is T125523 and the CAS number is 1831153-21-9.

Norswertianolin, a compound isolated from G. acuta, is a small molecule activator of CSE, which enhances the H-generation 2S activity of CSE and can be used in the study of cardiovascular diseases.

Norswertianin, a xanthone-based compound, acts as a potent anti-glioma agent. It promotes differentiation of GBM cells via oxidative stress and autophagy dependent on Akt mTOR signaling.

Swertianin 2-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside is a natural product for research related to life sciences. The catalog number is TN5919 and the CAS number is 136832-00-3.

Tetrahydroswertianolin is a natural product that can be used in related research in the field of life sciences. Its product number is TN8613.

1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its presence in food products with effective analytical methods. 2. Methyleugenol has insecticidal properties. 3. Methyleugenol can inhibit the production of nitric oxide and decreased the protein expression of inducible nitric oxide synthase, it down-regulates the production of pro-inflammatory cytokines in the ischemic brain as well as in immunostimulated mixed glial cells; indicates that methyleugenol could be useful for the treatment of ischemia inflammation-related diseases. 4. Methyleugenol has cytotoxicity and genotoxicity. 5. Intravenous (i.v.) treatment with methyleugenol (ME) in either anesthetized or conscious rats elicits hypotension, an effect that seems related to an active vascular relaxation rather than withdrawal of sympathetic tone. 6. Methyleugenol has antinociceptive effect on the second phase of formalin-induced pain, may be due to the inhibition of N-methyl-d-aspartic acid (NMDA) receptor-mediated hyperalgesia via GABA(A) receptors. 7. Methyleugenol has elaxant and antispasmodic actions on guinea-pig isolated ileum.

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induces apoptosis in A549 cells independently of cell cycle arrest, mediated by JNK and p38 MAPK signaling pathways. These pathways are activated due to oxidative DNA damage from increased ROS generation in MNQ-treated A549 cells.

Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis

Gentiakochianin (Swertianine), an anthrone from Gentianaceae, has vasodilatory activity, induces glioma cell cycle arrest in the G(2) M phase and inhibits proliferation, significantly reduces oxLDL-induced cell damage in EA.hy926 cells, inhibits ROS levels and up-regulated the activity of Akt CREB eNOS signaling pathway inhibited by oxLDL.

1. Sweroside possesses strong hepatoprotective effect. 2. Sweroside is a promising osteoporosis therapeutic natural product, has anti-osteoporotic effect on the human MG-63 cells and rat osteoblasts.

α-Glucosidase-IN-24 (Compound 13), an α-Glucosidase inhibitor derived from Swertia kouitchensis [1], exhibits an IC50 value of 451 μM.

Kouitchenside G, a natural compound extracted from Swertia kouitchensis, demonstrates inhibitory activity against α-Glucosidase, showcasing an IC 50 value of 956 μM [1].

Amaroswerin, a bioactive secoiridoid glucoside derived from Swertia mussotii, exhibits anti-inflammatory, antidiabetic, antiviral, anticholinergic, and immunomodulatory properties. It notably inhibits nitric oxide (NO) release in RAW264.7 cells with an IC50 value of 5.42 μg mL [1].

Compound 18, 1-O-Gentiobiosyl-3,7-dimethoxy-8-hydroxyxanthone, is a natural product isolated from Swertia mussotii [1].

Orientin 2''-O-p-trans-coumarate strongly promotes 2BS cell proliferation induced by H(2)O(2).

Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic, anti-inflammatory and antioxidant effects.

Angustin A is a natural product from Swertia angustifolia.

Angustin B is a natural product from Swertia angustifolia.

Erythrocentaurin has antibacterial activity; it also exhibits a concentration-dependent α-amylase inhibition (IC(50) 1.67 ± 0.28 mg mL).