sulfonamide class

Sulfamoxole (Sulfamoxol) is an antibacterial belonging to sulfonamide.

Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.

Ethiazide is a thiazole diuretic that inhibits renal tubular reabsorption of sodium and water, leading to increased urine output, reduced fluid retention, and decreased blood volume and blood pressure, Ethiazide is commonly applied in cardiovascular and renal research to study diuretic mechanisms and hypertension management.